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Gsk3a Gene Detail
Summary
  • Symbol
    Gsk3a
  • Name
    glycogen synthase kinase 3 alpha
  • Synonyms
    2700086H06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152453
    NCBI Gene: 606496
  • Gene Overview
    MyGene.info: GSK3A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:25228258-25237851 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9594 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.73 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GSK3A, glycogen synthase kinase 3 alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GSK3A, glycogen synthase kinase 3 alpha
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2931
    neXtProt AC: NX_P49840
    UniProt: P49840

  • Chr Location
    19q13.2; chr19:42230186-42243330 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin sensitivity, decreased fat mass and increased lean mass.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021123 VEGA Gene Model | MGI Sequence Detail 9594 C57BL/6J ±  kb
    transcript OTTMUST00000050005 VEGA | MGI Sequence Detail 2260 Not Applicable  
    polypeptide OTTMUSP00000023272 VEGA | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      48 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:1924078
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 20
      Gene Ontology 16
      Phenotypes 65
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:252647 Tran CW, et al., Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. J Immunol. 2017 Dec 15;199(12):4056-4065

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory