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Gsk3a
Gene Detail
Symbol

Name
ID
Gsk3a
glycogen synthase kinase 3 alpha
MGI:2152453
Synonyms
2700086H06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:25228258-25237851 bp, - strand
From VEGA annotation of GRCm38

  9594 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88581  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Gsk3a

Human
homologs
Human Homolog GSK3A, glycogen synthase kinase 3 alpha
NCBI Gene ID 2931
neXtProt AC  NX_P49840
Human Chr (Location)  19q13.2; chr19:42230186-42242584 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin sensitivity, decreased fat mass and increased lean mass.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Gsk3a interacts with 115 markers (Mir18, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process carbohydrate metabolic process, cardiac left ventricle morphogenesis, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (87)    Tissues (50)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 35
In situ reporter (knock in) 13
Western blot 34
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000021123 (Evidence)
Ensembl Gene ModelENSMUSG00000057177 (Evidence)
Entrez Gene606496 (Evidence)
EC2.7.11.1, 2.7.11.26
Consensus CDS ProjectCCDS20976.1
International Mouse Knockout Project StatusGsk3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021123 VEGA Gene Model | MGI Sequence Detail 9594 C57BL/6J ±  kb
transcript OTTMUST00000050005 VEGA | MGI Sequence Detail 2260 Not Applicable 
polypeptide OTTMUSP00000023272 VEGA | MGI Sequence Detail 490 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008287 glycogen synthase kinase-3 alpha
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212945 Schmid E, et al., Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3. PLoS One. 2014;9(2):e88637
All references(106)
Other
accession IDs
MGI:1924078

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory