Gsk3a
Gene Detail

Symbol Name ID

Gsk3a glycogen synthase kinase 3 alpha MGI:2152453

Synonyms

2700086H06Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 7

13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:25228258-25237851 bp, - strand From VEGA annotation of GRCm38   9594 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:88581  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Gsk3a

Human homologs

Human Homolog		GSK3A, glycogen synthase kinase 3 alpha
NCBI Gene ID		2931
neXtProt AC		NX_P49840
Human Chr (Location)		19q13.2; chr19:42734338-42746736 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(8) Gene trapped(2)
 

Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin sensitivity, decreased fat mass and increased lean mass.

 

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	carbohydrate metabolic process, cardiac left ventricle morphogenesis, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (62)    Tissues (39)    Images (17)
Theiler Stages: 1, 2, 3, 5, 19, 23, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	29
Western blot	28

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(6) Other(2)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000021123 (Evidence)
Ensembl Gene Model	ENSMUSG00000057177 (Evidence)
Entrez Gene	606496 (Evidence)
EC	2.7.11.1, 2.7.11.26
Consensus CDS Project	CCDS20976.1
International Mouse Knockout Project Status	Gsk3a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021123	VEGA Gene Model | MGI Sequence Detail	9594	C57BL/6J
transcript	OTTMUST00000050005	VEGA | MGI Sequence Detail	2260	Not Applicable
polypeptide	OTTMUSP00000023272	VEGA | MGI Sequence Detail	490	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000008287	glycogen synthase kinase-3 alpha

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:195008 Barrell WB, et al., Novel reporter alleles of GSK-3alpha and GSK-3beta. PLoS One. 2012;7(11):e50422
All references(91)

Other accession IDs

MGI:1924078