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Gsk3a
Gene Detail
Symbol

Name
ID
Gsk3a
glycogen synthase kinase 3 alpha
MGI:2152453
Synonyms
2700086H06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:25228258-25237851 bp, - strand
From VEGA annotation of GRCm38

  9594 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88581  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GSK3A
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Gsk3a

Human
homologs
GSK3A, glycogen synthase kinase 3 alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2931
neXtProt AC: NX_P49840

Human Chr (Location): 19q13.2; chr19:42230186-42242584 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit improved glucose tolerance, increased insulin sensitivity, decreased fat mass and increased lean mass.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Gsk3a interacts with 114 markers (Mir18, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process carbohydrate metabolic process, cardiac left ventricle morphogenesis, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (87)    Tissues (50)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 35
In situ reporter (knock in) 13
Western blot 34
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gsk3a    NEW 
Molecular
reagents
All nucleic(7) cDNA(6) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000021123 (Evidence)
Ensembl Gene Model ENSMUSG00000057177 (Evidence)
Entrez Gene 606496 (Evidence)
EC 2.7.11.1, 2.7.11.26
Consensus CDS Project CCDS20976.1
International Mouse Phenotyping Consortium Status Gsk3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021123 VEGA Gene Model | MGI Sequence Detail 9594 C57BL/6J ±  kb
transcript OTTMUST00000050005 VEGA | MGI Sequence Detail 2260 Not Applicable 
polypeptide OTTMUSP00000023272 VEGA | MGI Sequence Detail 490 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008287 glycogen synthase kinase-3 alpha
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:222524 Dembowy J, et al., Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis. Oncogene. 2015 Jul;34(27):3514-26
All references(107)
Other
accession IDs
MGI:1924078

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory