Usp3 MGI Mouse Gene Detail - MGI:2152450 - ubiquitin specific peptidase 3

Usp3 Gene Detail

Symbol

Usp3
Name

ubiquitin specific peptidase 3
Synonyms

MGC:28886

Feature Type

protein coding gene
IDs

MGI:2152450
NCBI Gene: 235441

Sequence Map

Chr9:66514637-66593142 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

78506 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 35.96 cM
Mapping Data

1 experiment

Human Ortholog

USP3, ubiquitin specific peptidase 3

Vertebrate Orthologs

10

Human Ortholog

USP3, ubiquitin specific peptidase 3
Orthology source: HomoloGene, HGNC
Synonyms

SIH003, UBP
Links

HGNC:12626

NCBI Gene ID: 9960

neXtProt AC: NX_Q9Y6I4

UniProt: Q9Y6I4
Chr Location

15q22.31; chr15:63504511-63594640 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 4766
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: USP3
Gene Tree

Usp3

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Phenotype Summary

1 phenotype from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Gene trapped

7
Targeted

5
Genomic Mutations

1 involving Usp3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available

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All GO Annotations

30
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

5
Tissues

5
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase usp3

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Usp3 interacts with 374 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

76
RefSeq

18
UniProt

5
CCDS

CCDS23305.1, CCDS81025.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023730	VEGA Gene Model \| MGI Sequence Detail	78506	C57BL/6J	± kb
transcript	OTTMUST00000057953	VEGA \| MGI Sequence Detail	5607	Not Applicable
polypeptide	OTTMUSP00000028024	VEGA \| MGI Sequence Detail	520	Not Applicable

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SNPs within 2kb

227 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000017168 ubiquitin carboxyl-terminal hydrolase 3

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001607 Zinc finger, UBP-type

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All nucleic 12

cDNA 12

Microarray probesets 6

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MGI:2142934, MGI:2385312

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 12
Earliest

J:85124 Sousa-Nunes R, et al., Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Genome Res. 2003 Dec;13(12):2609-20
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/13/2017 MGI 6.10