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Usp3 Gene Detail
Summary
  • Symbol
    Usp3
  • Name
    ubiquitin specific peptidase 3
  • Synonyms
    MGC:28886
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152450
    NCBI Gene: 235441
Location & Maps
more
  • Sequence Map
    Chr9:66514637-66593142 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      78506 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 35.96 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    USP3, ubiquitin specific peptidase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP3, ubiquitin specific peptidase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIH003, UBP
  • Links
    NCBI Gene ID: 9960
    neXtProt AC: NX_Q9Y6I4

  • Chr Location
    15q22.3; chr15:63504511-63594640 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 4766
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: USP3
  • Gene Tree
    Usp3
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    5
  • Genomic Mutations
    1 involving Usp3
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    5
  • Tissues
    5
  • cDNA Data
    12
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023730 VEGA Gene Model | MGI Sequence Detail 78506 C57BL/6J ±  kb
transcript OTTMUST00000057953 VEGA | MGI Sequence Detail 5607 Not Applicable  
polypeptide OTTMUSP00000028024 VEGA | MGI Sequence Detail 520 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    227 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000017168 ubiquitin carboxyl-terminal hydrolase 3
  • EC
    3.4.19.12
  • InterPro Domains
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
    IPR033302 Ubquitin-specific protease 3, animal
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001607 Zinc finger, UBP-type
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142934, MGI:2385312
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:85124 Sousa-Nunes R, et al., Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Genome Res. 2003 Dec;13(12):2609-20
  • Latest
    J:218723 Lancini C, et al., Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells. J Exp Med. 2014 Aug 25;211(9):1759-77
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory