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Usp3 Gene Detail
Summary
  • Symbol
    Usp3
  • Name
    ubiquitin specific peptidase 3
  • Synonyms
    MGC:28886
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152450
    NCBI Gene: 235441
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:66514637-66593142 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 35.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152450
 protein coding gene Chr9:66514637-66593148 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034977
 protein coding gene Chr9:66360193-66447345 (-)
A/J MGP_AJ_G0034957
 protein coding gene Chr9:64067947-64148071 (-)
AKR/J MGP_AKRJ_G0034887
 protein coding gene Chr9:65610713-65689458 (-)
BALB/cJ MGP_BALBcJ_G0034950
 protein coding gene Chr9:63793172-63871427 (-)
C3H/HeJ MGP_C3HHeJ_G0034659
 protein coding gene Chr9:66127933-66211002 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035469
 protein coding gene Chr9:68172377-68256285 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032380
 protein coding gene Chr9:63713276-63795430 (-)
CAST/EiJ MGP_CASTEiJ_G0033981
 protein coding gene Chr9:66343100-66434516 (-)
CBA/J MGP_CBAJ_G0034631
 protein coding gene Chr9:70511317-70596168 (-)
DBA/2J MGP_DBA2J_G0034790
 protein coding gene Chr9:63847663-63926884 (-)
FVB/NJ MGP_FVBNJ_G0034732
 protein coding gene Chr9:63191793-63269857 (-)
LP/J MGP_LPJ_G0034873
 protein coding gene Chr9:66607585-66691749 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034774
 protein coding gene Chr9:71762111-71844748 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035491
 protein coding gene Chr9:65711913-65792750 (-)
PWK/PhJ MGP_PWKPhJ_G0033685
 protein coding gene Chr9:64053771-64133275 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033519
 protein coding gene Chr9:66015015-66103755 (-)
WSB/EiJ MGP_WSBEiJ_G0034094
 protein coding gene Chr9:65609509-65688932 (-)



Homology
more
  • Human Ortholog
    USP3, ubiquitin specific peptidase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP3, ubiquitin specific peptidase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIH003, UBP
  • Links
    NCBI Gene ID: 9960
    neXtProt AC: NX_Q9Y6I4
    UniProt: Q9Y6I4

  • Chr Location
    15q22.31; chr15:63504511-63594640 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 4766
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: USP3
  • Gene Tree
    Usp3
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    5
  • Tissues
    5
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032376 Ensembl Gene Model | MGI Sequence Detail 78506 C57BL/6J ±  kb
    transcript ENSMUST00000127569 Ensembl | MGI Sequence Detail 5607 Not Applicable  
    polypeptide ENSMUSP00000122199 Ensembl | MGI Sequence Detail 520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142934, MGI:2385312
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:85124 Sousa-Nunes R, et al., Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Genome Res. 2003 Dec;13(12):2609-20
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    02/18/2020
    MGI 6.14     		The Jackson Laboratory