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Pth2 Gene Detail
Summary
  • Symbol
    Pth2
  • Name
    parathyroid hormone 2
  • Synonyms
    Tifp39, TIP39
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152297
    NCBI Gene: 114640
  • Gene Overview
    MyGene.info: PTH2
Location & Maps
more
  • Sequence Map
    Chr7:45180995-45181838 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      844 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.17 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PTH2, parathyroid hormone 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PTH2, parathyroid hormone 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TIP39
  • Links
    NCBI Gene ID: 113091
    neXtProt AC: NX_Q96A98

  • Chr Location
    19q13.33; chr19:49422414-49426263 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    2
  • Transgenic
    1
Both sexes of mice homozygous for a null allele are sterile. Female homozygotes display very small atretic ovaries without follicles while male homozygotes lack postmeiotic germ cells due to a block during prophase of meiosis I and subsequent death of developing spermatocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038300 Ensembl Gene Model | MGI Sequence Detail 844 C57BL/6J ±  kb
transcript ENSMUST00000042754 Ensembl | MGI Sequence Detail 569 Not Applicable  
polypeptide ENSMUSP00000041047 Ensembl | MGI Sequence Detail 100 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    30 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013431 tuberoinfundibular peptide of 39 residues
  • InterPro Domains
    IPR029396 Tuberoinfundibular peptide of 39 residues
Molecular
Reagents
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  • All nucleic 4
    Genomic 1
    cDNA 1
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:74512 Dobolyi A, et al., Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1651-6
  • Latest
    J:226164 Tsuda MC, et al., Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala. J Neurosci. 2015 Sep 2;35(35):12152-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory