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Pth2
Gene Detail
Symbol

Name
ID
Pth2
parathyroid hormone 2
MGI:2152297
Synonyms
Tifp39, TIP39
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:45180995-45181838 bp, + strand
From Ensembl annotation of GRCm38

  844 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14235  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PTH2
Gene Tree: Pth2

Human
homologs
PTH2, parathyroid hormone 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 113091
neXtProt AC: NX_Q96A98

Human Synonyms: TIP39

Human Chr (Location): 19q13.33; chr19:49422414-49426263 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
 
Both sexes of mice homozygous for a null allele are sterile. Female homozygotes display very small atretic ovaries without follicles while male homozygotes lack postmeiotic germ cells due to a block during prophase of meiosis I and subsequent death of developing spermatocytes.
 
Interactions
Pth2 interacts with 2 markers (Mir322, Mir497)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cAMP biosynthetic process, neuropeptide signaling pathway
Component extracellular region
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(1)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: ZFIN pth2    NEW 
Molecular
reagents
All nucleic(4) Genomic(1) cDNA(1) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000038300 (Evidence)
Entrez Gene 114640 (Evidence)
UniGene 207078
DoTS DT.94276062, DT.101718622
NIA Mouse Gene Index U008067
Consensus CDS Project CCDS21233.1
International Mouse Phenotyping Consortium Status Pth2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038300 Ensembl Gene Model | MGI Sequence Detail 844 C57BL/6J ±  kb
transcript ENSMUST00000042754 Ensembl | MGI Sequence Detail 569 Not Applicable 
polypeptide ENSMUSP00000041047 Ensembl | MGI Sequence Detail 100 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000013431 tuberoinfundibular peptide of 39 residues
References
(Earliest) J:74512 Dobolyi A, et al., Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1651-6
(Latest) J:200701 Dimitrov EL, et al., Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13156-61
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory