Necab2 MGI Mouse Gene Detail - MGI:2152211 - N-terminal EF-hand calcium binding protein 2

Symbol

Necab2
Name

N-terminal EF-hand calcium binding protein 2
Synonyms

Efcbp2, Necab2

Feature Type

protein coding gene
IDs

MGI:2152211
NCBI Gene: 117148
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:120173458-120199379 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 67.73 cM, cytoband E1
Mapping Data

4 experiments

SNPs within 2kb

155 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152211	protein coding gene	Chr8:120173431-120199379 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034182	protein coding gene	Chr8:122758222-122786127 (+)
A/J	MGP_AJ_G0034162	protein coding gene	Chr8:117717264-117743180 (+)
AKR/J	MGP_AKRJ_G0034089	protein coding gene	Chr8:121130789-121156712 (+)
BALB/cJ	MGP_BALBcJ_G0034156	protein coding gene	Chr8:117920071-117946294 (+)
C3H/HeJ	MGP_C3HHeJ_G0033867	protein coding gene	Chr8:121865726-121891649 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034676	protein coding gene	Chr8:126875645-126901567 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031618	protein coding gene	Chr8:110608431-110634015 (+)
CAST/EiJ	MGP_CASTEiJ_G0033194	protein coding gene	Chr8:121803372-121830777 (+)
CBA/J	MGP_CBAJ_G0033840	protein coding gene	Chr8:131490341-131516525 (+)
DBA/2J	MGP_DBA2J_G0033996	protein coding gene	Chr8:116940838-116966746 (+)
FVB/NJ	MGP_FVBNJ_G0033939	protein coding gene	Chr8:115965657-115991685 (+)
LP/J	MGP_LPJ_G0034085	protein coding gene	Chr8:122912853-122938770 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033986	protein coding gene	Chr8:133943636-133970471 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034694	protein coding gene	Chr8:121282999-121308917 (+)
PWK/PhJ	MGP_PWKPhJ_G0032896	protein coding gene	Chr8:116692513-116719290 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032736	protein coding gene	Chr8:119982039-120011800 (+)
WSB/EiJ	MGP_WSBEiJ_G0033310	protein coding gene	Chr8:122002582-122028434 (+)

Human Ortholog

NECAB2, N-terminal EF-hand calcium binding protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NECAB2, N-terminal EF-hand calcium binding protein 2
Synonyms

EFCBP2, stip-2
Links

HGNC:23746

NCBI Gene ID: 54550

neXtProt AC: NX_Q7Z6G3

UniProt: Q7Z6G3
Chr Location

16q23.3; chr16:83965177-84002776 (+) GRCh38

MGI Vertebrate Homology

Necab2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NECAB2
Gene Tree

Necab2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a knock-out allele exhibit spermatid gigantism.

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All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

44
cDNA Data

14
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase necab2

ZFIN necab2

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All Sequences

42
RefSeq

8
UniProt

3
CCDS

CCDS22705.1

Ensembl

ENSMUSG00000031837 (Evidence)
NCBI Gene

117148

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031837	Ensembl Gene Model \| MGI Sequence Detail	25922	C57BL/6J	± kb
transcript	ENSMUST00000098363	Ensembl \| MGI Sequence Detail	1976	Not Applicable
polypeptide	ENSMUSP00000095966	Ensembl \| MGI Sequence Detail	389	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011110 N-terminal EF-hand calcium-binding protein 2

(term hierarchy)
InterPro Domains

IPR007138 Antibiotic biosynthesis monooxygenase domain

IPR011008 Dimeric alpha-beta barrel

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR039862 N-terminal EF-hand calcium binding protein 1/2/3

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All nucleic 15

cDNA 15

Microarray probesets 2

Summaries

All 36

Developmental Gene Expression 8

Gene Ontology 5

Phenotypes 6
Earliest

J:71879 Bernier G, et al., Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium. Development. 2001 Oct;128(20):3987-94
Latest

J:340881 Bueno D, et al., NECAB2 is an endosomal protein important for striatal function. Free Radic Biol Med. 2023 Sep 16;208:643-656

TSS for Necab2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79696	Chr8:120173484-120173505 (+)	37 bp
Tssr79697	Chr8:120173580-120173591 (+)	128 bp
Tssr79698	Chr8:120173661-120173686 (+)	216 bp
Tssr79699	Chr8:120173777-120173874 (+)	368 bp
Tssr79700	Chr8:120192015-120192044 (+)	18,572 bp
Tssr79701	Chr8:120193171-120193189 (+)	19,722 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23