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Cyyr1 Gene Detail
Summary
  • Symbol
    Cyyr1
  • Name
    cysteine and tyrosine-rich protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152187
    NCBI Gene: 224405
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:85247245-85347793 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 47.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2936 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152187
 protein coding gene Chr16:85218421-85350285 (-)
129S1/SvImJ ENSMUSG00200037874
 protein coding gene Chr16:82116885-82245771 (-)
A/J ENSMUSG00195026397
 protein coding gene Chr16:81918011-82044547 (-)
AKR/J ENSMUSG00220015865
 protein coding gene Chr16:82064779-82193705 (-)
BALB/cJ ENSMUSG00180014347
 protein coding gene Chr16:81964354-82090436 (-)
C3H/HeJ ENSMUSG00175015787
 protein coding gene Chr16:82277960-82404483 (-)
C57BL/6NJ ENSMUSG00215026028
 protein coding gene Chr16:82083057-82211979 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020893
 protein coding gene Chr16:80065592-80158152 (-)
CAST/EiJ ENSTCUG00005017920
 protein coding gene Chr16:81728207-81854829 (-)
CBA/J ENSMUSG00210032180
 protein coding gene Chr16:82190235-82316333 (-)
DBA/2J ENSMUSG00185030684
 protein coding gene Chr16:82129835-82256353 (-)
FVB/NJ ENSMUSG00205012902
 protein coding gene Chr16:81950611-82073590 (-)
JF1/MsJ ENSUMUG00000014513
 protein coding gene Chr16:82255485-82378307 (-)
LP/J ENSMUSG00230030775
 protein coding gene Chr16:84678086-84806967 (-)
NOD/ShiLtJ ENSMUSG00190019536
 protein coding gene Chr16:82135153-82261668 (-)
NZO/HlLtJ ENSMUSG00225030824
 protein coding gene Chr16:87820813-87946931 (-)
PWK/PhJ ENSLUMG00010011758
 protein coding gene Chr16:81923441-82046488 (-)
SPRET/EiJ ENSMSPG00010028744
 protein coding gene Chr16:82883949-83005768 (-)
WSB/EiJ ENSIUOG00005017578
 protein coding gene Chr16:82089058-82215618 (-)



Homology
more
  • Human Ortholog
    CYYR1, cysteine and tyrosine rich 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYYR1, cysteine and tyrosine rich 1
  • Synonyms
    C21orf95
  • Links
    NCBI Gene ID: 116159
    UniProt: Q96J86

  • Chr Location
    21q21.3; chr21:26466209-26573286 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    666
  • Tissues
    67
  • cDNA Data
    16
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 224405 NCBI Gene Model | MGI Sequence Detail 100549 C57BL/6J ±  kb
transcript NM_144853 RefSeq | MGI Sequence Detail 7942 ZRU/MplStud  
polypeptide Q8VIH7 UniProt | EBI | MGI Sequence Detail 165 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 16
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 19
  • Earliest
    J:76846 Reymond A, et al., Nineteen additional unpredicted transcripts from human chromosome 21. Genomics. 2002 Jun;79(6):824-32
  • Latest
    J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory