About   Help   FAQ
Ngb Gene Detail
Summary
  • Symbol
    Ngb
  • Name
    neuroglobin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151886
    NCBI Gene: 64242
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:87097531-87102539 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5009 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 41.29 cM, cytoband D3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NGB, neuroglobin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NGB, neuroglobin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 58157
    neXtProt AC: NX_Q9NPG2
    UniProt: Q9NPG2

  • Chr Location
    14q24.3; chr14:77265491-77271312 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10942
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NGB
  • Protein SuperFamily
  • Gene Tree
    Ngb
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a significantly larger phase delay of circadian rhythm upon light stimulation at early night.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020165 VEGA Gene Model | MGI Sequence Detail 5009 C57BL/6J ±  kb
transcript OTTMUST00000047919 VEGA | MGI Sequence Detail 1611 Not Applicable  
polypeptide OTTMUSP00000021838 VEGA | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    39 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 10
    Primer pair 2
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 60
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:64988 Burmester T, et al., A vertebrate globin expressed in the brain. Nature. 2000 Sep 28;407(6803):520-3
  • Latest
    J:258100 Nowotny M, et al., Hearing Without Neuroglobin. Neuroscience. 2017 Dec 16;366:138-148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/09/2018
MGI 6.12
The Jackson Laboratory