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Ngb Gene Detail
Summary
  • Symbol
    Ngb
  • Name
    neuroglobin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151886
    NCBI Gene: 64242
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr12:87097531-87102539 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 41.29 cM, cytoband D3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151886
protein coding gene Chr12:87097531-87102539 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019977
protein coding gene Chr12:87989254-87994251 (-)
A/J MGP_AJ_G0019935
protein coding gene Chr12:84644865-84649869 (-)
AKR/J MGP_AKRJ_G0019910
protein coding gene Chr12:86938859-86945597 (-)
BALB/cJ MGP_BALBcJ_G0019914
protein coding gene Chr12:84977153-84982701 (-)
C3H/HeJ MGP_C3HHeJ_G0019720
protein coding gene Chr12:87426598-87432515 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020366
protein coding gene Chr12:90522248-90527736 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017984
protein coding gene Chr12:81530030-81535092 (-)
CAST/EiJ MGP_CASTEiJ_G0019270
protein coding gene Chr12:82450699-82455910 (-)
CBA/J MGP_CBAJ_G0019692
protein coding gene Chr12:94005668-94012291 (-)
DBA/2J MGP_DBA2J_G0019805
protein coding gene Chr12:84132387-84137465 (-)
FVB/NJ MGP_FVBNJ_G0019792
protein coding gene Chr12:83129360-83134364 (-)
LP/J MGP_LPJ_G0019879
protein coding gene Chr12:87866984-87871957 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019831
protein coding gene Chr12:96748111-96753178 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020398
protein coding gene Chr12:86567788-86574565 (-)
PWK/PhJ MGP_PWKPhJ_G0019034
protein coding gene Chr12:78690555-78695897 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018829
protein coding gene Chr12:81060289-81065341 (-)
WSB/EiJ MGP_WSBEiJ_G0019323
protein coding gene Chr12:87341599-87346697 (-)



Homology
more
  • Human Ortholog
    NGB, neuroglobin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NGB, neuroglobin
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 58157
    neXtProt AC: NX_Q9NPG2
    UniProt: Q9NPG2

  • Chr Location
    14q24.3; chr14:77265491-77271312 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10942
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NGB
  • Protein SuperFamily
  • Gene Tree
    Ngb
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a significantly larger phase delay of circadian rhythm upon light stimulation at early night.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 64242 NCBI Gene Model | MGI Sequence Detail 5009 C57BL/6J ±  kb
transcript NM_001294308 RefSeq | MGI Sequence Detail 1644 C57BL/6  
polypeptide Q9ER97 UniProt | EBI | MGI Sequence Detail 151 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 10
    Primer pair 2
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 59
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:64988 Burmester T, et al., A vertebrate globin expressed in the brain. Nature. 2000 Sep 28;407(6803):520-3
  • Latest
    J:258100 Nowotny M, et al., Hearing Without Neuroglobin. Neuroscience. 2017 Dec 16;366:138-148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory