Ppp1r16b MGI Mouse Gene Detail - MGI:2151841 - protein phosphatase 1, regulatory subunit 16B

Symbol

Ppp1r16b
Name

protein phosphatase 1, regulatory subunit 16B
Synonyms

ANKRD4, C130078N17Rik, Wdt4

Feature Type

protein coding gene
IDs

MGI:2151841
NCBI Gene: 228852
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr2:158508653-158608254 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.72 cM
Mapping Data

2 experiments

SNPs within 2kb

3014 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151841	protein coding gene	Chr2:158507318-158608254 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026799	protein coding gene	Chr2:163758052-163865416 (+)
A/J	MGP_AJ_G0026765	protein coding gene	Chr2:157181952-157287957 (+)
AKR/J	MGP_AKRJ_G0026736	protein coding gene	Chr2:161809603-161912870 (+)
BALB/cJ	MGP_BALBcJ_G0026774	protein coding gene	Chr2:157492398-157595824 (+)
C3H/HeJ	MGP_C3HHeJ_G0026516	protein coding gene	Chr2:162161736-162263287 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027223	protein coding gene	Chr2:168630240-168740705 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024593	protein coding gene	Chr2:150624234-150722899 (+)
CAST/EiJ	MGP_CASTEiJ_G0025978	protein coding gene	Chr2:162508190-162618456 (+)
CBA/J	MGP_CBAJ_G0026493	protein coding gene	Chr2:174683301-174800714 (+)
DBA/2J	MGP_DBA2J_G0026631	protein coding gene	Chr2:156359092-156469807 (+)
FVB/NJ	MGP_FVBNJ_G0026598	protein coding gene	Chr2:154776821-154883197 (+)
LP/J	MGP_LPJ_G0026734	protein coding gene	Chr2:163850810-163961760 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026619	protein coding gene	Chr2:178457187-178564505 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027279	protein coding gene	Chr2:161652661-161761729 (+)
PWK/PhJ	MGP_PWKPhJ_G0025712	protein coding gene	Chr2:155901300-156003714 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025515	protein coding gene	Chr2:160572569-160676866 (+)
WSB/EiJ	MGP_WSBEiJ_G0026048	protein coding gene	Chr2:162542629-162658054 (+)

Human Ortholog

PPP1R16B, protein phosphatase 1 regulatory subunit 16B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1R16B, protein phosphatase 1 regulatory subunit 16B
Synonyms

ANKRD4, TIMAP
Links

HGNC:15850

NCBI Gene ID: 26051

UniProt: Q96T49
Chr Location

20q11.23; chr20:38805697-38923024 (+) GRCh38

MGI Vertebrate Homology

Ppp1r16b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPP1R16B
Protein SuperFamily

PP1_16AB_vert
Gene Tree

Ppp1r16b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
7 phenotype references

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile and grossly normal with no detectable defects in thymopoiesis.

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All GO Annotations

34
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1010
Tissues

69
cDNA Data

11
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp1r16b

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All Sequences

53
RefSeq

8
UniProt

4
CCDS

CCDS16991.1

Ensembl

ENSMUSG00000037754 (Evidence)
NCBI Gene

228852

			Length	Strain/Species	Flank
genomic	228852	NCBI Gene Model \| MGI Sequence Detail	99602	C57BL/6J	± kb
transcript	NM_001159662	RefSeq \| MGI Sequence Detail	6392	C57BL/6
polypeptide	Q8VHQ3	UniProt \| EBI \| MGI Sequence Detail	568	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013119 protein phosphatase 1 regulatory inhibitor subunit 16B

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR051226 Protein Phosphatase 1 Regulatory Subunit

IPR017417 Protein phosphatase 1, regulatory subunit 16A/B
GlyGen

Q8VHQ3 3 sites, 1 O-linked glycan (2 sites)

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All nucleic 13

cDNA 11

Primer pair 1

Other 1

Microarray probesets 4

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MGI:2442756

Summaries

All 40

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 7
Earliest

J:71159 Bleul CC, et al., Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product. Eur J Immunol. 2001 Aug;31(8):2497-503
Latest

J:334587 Wang L, et al., Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction. Circ Res. 2022 Aug 19;131(5):371-387

TSS for Ppp1r16b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr728	Chr2:158508318-158508359 (+)	-314 bp
Tssr21366	Chr2:158508517-158508566 (+)	-111 bp
Tssr21367	Chr2:158508578-158508592 (+)	-68 bp
Tssr21368	Chr2:158508610-158508660 (+)	-18 bp
Tssr21369	Chr2:158508663-158508672 (+)	15 bp
Tssr21370	Chr2:158509039-158509050 (+)	392 bp
Tssr21371	Chr2:158509051-158509106 (+)	426 bp
Tssr21372	Chr2:158509111-158509114 (+)	460 bp
Tssr21373	Chr2:158509998-158510037 (+)	1,365 bp
Tssr21374	Chr2:158542891-158542892 (+)	34,239 bp
Tssr21375	Chr2:158565359-158565370 (+)	56,712 bp
Tssr21376	Chr2:158565375-158565387 (+)	56,728 bp
Tssr21377	Chr2:158604038-158604057 (+)	95,395 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24