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Ppp1r16b Gene Detail
Summary
  • Symbol
    Ppp1r16b
  • Name
    protein phosphatase 1, regulatory subunit 16B
  • Synonyms
    ANKRD4, C130078N17Rik, Wdt4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151841
    NCBI Gene: 228852
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:158508653-158608254 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    770 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151841
 protein coding gene Chr2:158507318-158608254 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026799
 protein coding gene Chr2:163758052-163865416 (+)
A/J MGP_AJ_G0026765
 protein coding gene Chr2:157181952-157287957 (+)
AKR/J MGP_AKRJ_G0026736
 protein coding gene Chr2:161809603-161912870 (+)
BALB/cJ MGP_BALBcJ_G0026774
 protein coding gene Chr2:157492398-157595824 (+)
C3H/HeJ MGP_C3HHeJ_G0026516
 protein coding gene Chr2:162161736-162263287 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027223
 protein coding gene Chr2:168630240-168740705 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024593
 protein coding gene Chr2:150624234-150722899 (+)
CAST/EiJ MGP_CASTEiJ_G0025978
 protein coding gene Chr2:162508190-162618456 (+)
CBA/J MGP_CBAJ_G0026493
 protein coding gene Chr2:174683301-174800714 (+)
DBA/2J MGP_DBA2J_G0026631
 protein coding gene Chr2:156359092-156469807 (+)
FVB/NJ MGP_FVBNJ_G0026598
 protein coding gene Chr2:154776821-154883197 (+)
LP/J MGP_LPJ_G0026734
 protein coding gene Chr2:163850810-163961760 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026619
 protein coding gene Chr2:178457187-178564505 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027279
 protein coding gene Chr2:161652661-161761729 (+)
PWK/PhJ MGP_PWKPhJ_G0025712
 protein coding gene Chr2:155901300-156003714 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025515
 protein coding gene Chr2:160572569-160676866 (+)
WSB/EiJ MGP_WSBEiJ_G0026048
 protein coding gene Chr2:162542629-162658054 (+)



Homology
more
  • Human Ortholog
    PPP1R16B, protein phosphatase 1 regulatory subunit 16B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R16B, protein phosphatase 1 regulatory subunit 16B
  • Synonyms
    ANKRD4, TIMAP
  • Links
    NCBI Gene ID: 26051
    neXtProt AC: NX_Q96T49
    UniProt: Q96T49

  • Chr Location
    20q11.23; chr20:38805693-38923024 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and grossly normal with no detectable defects in thymopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    974
  • Tissues
    67
  • cDNA Data
    11
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 228852 NCBI Gene Model | MGI Sequence Detail 99602 C57BL/6J ±  kb
transcript NM_001159662 RefSeq | MGI Sequence Detail 6392 C57BL/6  
polypeptide Q8VHQ3 UniProt | EBI | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2442756
References
more
  • Summaries
    All 32
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:71159 Bleul CC, et al., Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product. Eur J Immunol. 2001 Aug;31(8):2497-503
  • Latest
    J:281339 Wang X, et al., TIMAP inhibits endothelial myosin light chain phosphatase by competing with MYPT1 for the catalytic protein phosphatase 1 subunit PP1cbeta. J Biol Chem. 2019 Sep 6;294(36):13280-13291
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/23/2022
MGI 6.20 		The Jackson Laboratory