Mreg
Gene Detail

Symbol Name ID

Mreg melanoregulin MGI:2151839

Synonyms

dsu, LOC381269, Wdt2

Feature Type

protein coding gene

Genetic Map

Chromosome 1

36.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr1:72159233-72212307 bp, - strand From NCBI annotation of GRCm38   53075 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mreg

Human homologs

Human Homolog		MREG, melanoregulin
NCBI Gene ID		55686
neXtProt AC		NX_Q8N565
Human Synonyms		DSU, WDT2
Human Chr (Location)		2q35; chr2:216807314-216878346 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(199) : Targeted(3) Gene trapped(195) Spontaneous(1)
 

A spontaneous suppressor mutation restores normal melanocyte morphology and therefore coat color in mutations producing coat color dilution.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	anagen, developmental pigmentation, ...
Component	membrane, plasma membrane

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (18)    Images (2)
Theiler Stages: 10, 18, 20, 23, 25, 28

Assay Type	Results
RNA in situ	2
Northern blot	22
RT-PCR	3

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(6) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000039395 (Evidence)
Entrez Gene	381269 (Evidence)
DFCI	TC1584937, TC1662645
DoTS	DT.102556178
NIA Mouse Gene Index	U021459
Consensus CDS Project	CCDS15032.1
International Mouse Knockout Project Status	Mreg

Sequences

Length	Strain/Species
genomic	381269	NCBI Gene Model | MGI Sequence Detail	53075	C57BL/6J
transcript	NM_001005423	RefSeq | MGI Sequence Detail	2493	C57BL/6
polypeptide	Q6NVG5	UniProt | EBI | MGI Sequence Detail	214	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(229 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000010563	melanoregulin

Graphical View of Protein Domain Structure

References

(Earliest) J:7171 Sweet HO, Dilute suppressor, a new suppressor gene in the house mouse. J Hered. 1983 Jul-Aug;74(4):305-6
(Latest) J:191882 Rachel RA, et al., Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis. PLoS One. 2012;7(9):e42446
All references(46)

Other accession IDs

MGD-MRK-8909, MGI:2685820, MGI:94933