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Mreg
Gene Detail
 Symbol
Name
ID
Mreg
melanoregulin
MGI:2151839
Synonyms dsu, LOC381269, Wdt2
Feature Type protein coding gene
Genetic Map
Chromosome 1
36.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:72159442-72212307 bp, - strand
From VEGA annotation of GRCm38

  52866 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Mreg

Human
homologs
Human Homolog MREG, melanoregulin
NCBI Gene ID 55686
neXtProt AC  NX_Q8N565
Human Synonyms  DSU, WDT2
Human Chr (Location)  2q35; chr2:215942591-216013623 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(199) : Gene trapped(195) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
A spontaneous suppressor mutation restores normal melanocyte morphology and therefore coat color in mutations producing coat color dilution.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Mreg interacts with 193 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process anagen, developmental pigmentation, ...
Component melanosome, membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (18)    Images (2)
Theiler Stages: 10, 18, 20, 23, 25, 28
Assay TypeResults
RNA in situ 2
Northern blot 22
RT-PCR 3
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(23) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049069 (Evidence)
Ensembl Gene ModelENSMUSG00000039395 (Evidence)
Entrez Gene381269 (Evidence)
UniGene422636
DFCITC1584937, TC1662645
DoTSDT.102556178
NIA Mouse Gene IndexU021459
Consensus CDS ProjectCCDS15032.1
International Mouse Knockout Project StatusMreg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049069 VEGA Gene Model | MGI Sequence Detail 52866 C57BL/6J ±  kb
transcript OTTMUST00000125321 VEGA | MGI Sequence Detail 2284 Not Applicable 
polypeptide OTTMUSP00000067977 VEGA | MGI Sequence Detail 214 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(328 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000010563 melanoregulin
References (Earliest) J:7171 Sweet HO, Dilute suppressor, a new suppressor gene in the house mouse. J Hered. 1983 Jul-Aug;74(4):305-6
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(51)
Other
accession IDs
MGD-MRK-8909, MGI:2685820, MGI:94933

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory