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Mreg
Gene Detail
 Symbol
Name
ID
Mreg
melanoregulin
MGI:2151839
Synonyms dsu, LOC381269, Wdt2
Feature Type protein coding gene
Genetic Map
Chromosome 1
36.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:72159233-72212307 bp, - strand
From NCBI annotation of GRCm38

  53075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Mreg

Human
homologs
Human Homolog MREG, melanoregulin
NCBI Gene ID 55686
neXtProt AC  NX_Q8N565
Human Synonyms  DSU, WDT2
Human Chr (Location)  2q35; chr2:215942591-216013623 (-)  GRCh38
Alleles
and
phenotypes
All alleles(199) : Gene trapped(195) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
A spontaneous suppressor mutation restores normal melanocyte morphology and therefore coat color in mutations producing coat color dilution.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process anagen, developmental pigmentation, ...
Component melanosome, membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (18)    Images (2)
Theiler Stages: 10, 18, 20, 23, 25, 28
Assay TypeResults
RNA in situ 2
Northern blot 22
RT-PCR 3
cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(25) cDNA(23) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000039395 (Evidence)
Entrez Gene381269 (Evidence)
UniGene422636
DFCITC1584937, TC1662645
DoTSDT.102556178
NIA Mouse Gene IndexU021459
Consensus CDS ProjectCCDS15032.1
International Mouse Knockout Project StatusMreg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 381269 NCBI Gene Model | MGI Sequence Detail 53075 C57BL/6J ±  kb
transcript NM_001005423 RefSeq | MGI Sequence Detail 2493 C57BL/6 
polypeptide Q6NVG5 UniProt | EBI | MGI Sequence Detail 214 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(330 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000010563 melanoregulin
Graphical View of Protein Domain Structure
References (Earliest) J:7171 Sweet HO, Dilute suppressor, a new suppressor gene in the house mouse. J Hered. 1983 Jul-Aug;74(4):305-6
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(50)
Other
accession IDs
MGD-MRK-8909, MGI:2685820, MGI:94933

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory