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Mreg Gene Detail
Summary
  • Symbol
    Mreg
  • Name
    melanoregulin
  • Synonyms
    dsu, LOC381269, Wdt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151839
    NCBI Gene: 381269
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:72159442-72212307 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 36.39 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    327 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151839
protein coding gene Chr1:72159233-72212307 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016128
protein coding gene Chr1:72636372-72698967 (-)
A/J MGP_AJ_G0016111
protein coding gene Chr1:70049288-70108030 (-)
AKR/J MGP_AKRJ_G0016068
protein coding gene Chr1:72067488-72119871 (-)
BALB/cJ MGP_BALBcJ_G0016066
protein coding gene Chr1:70183006-70238615 (-)
C3H/HeJ MGP_C3HHeJ_G0015897
protein coding gene Chr1:72387117-72440730 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016519
protein coding gene Chr1:75449966-75508873 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014240
protein coding gene Chr1:65768601-65823671 (-)
CAST/EiJ MGP_CASTEiJ_G0015481
protein coding gene Chr1:71639183-71723420 (-)
CBA/J MGP_CBAJ_G0015870
protein coding gene Chr1:77920291-77972782 (-)
DBA/2J MGP_DBA2J_G0015971
protein coding gene Chr1:69455992-69508383 (-)
FVB/NJ MGP_FVBNJ_G0015974
protein coding gene Chr1:68635627-68687865 (-)
LP/J MGP_LPJ_G0016043
protein coding gene Chr1:73709478-73760733 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015994
protein coding gene Chr1:81411710-81468596 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016566
protein coding gene Chr1:72070836-72128388 (-)
PWK/PhJ MGP_PWKPhJ_G0015268
protein coding gene Chr1:68862734-68944263 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015047
protein coding gene Chr1:71479441-71531409 (-)
WSB/EiJ MGP_WSBEiJ_G0015543
protein coding gene Chr1:71899748-71960044 (-)



Homology
more
  • Human Ortholog
    MREG, melanoregulin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MREG, melanoregulin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DSU, WDT2
  • Links
    NCBI Gene ID: 55686
    neXtProt AC: NX_Q8N565
    UniProt: Q8N565

  • Chr Location
    2q35; chr2:215939097-216013623 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9954
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MREG
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from multigenic genotypes
    3 images
    27 phenotype references
A spontaneous suppressor mutation restores normal melanocyte morphology and therefore coat color in mutations producing coat color dilution.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039395 Ensembl Gene Model | MGI Sequence Detail 52866 C57BL/6J ±  kb
transcript ENSMUST00000048860 Ensembl | MGI Sequence Detail 2284 Not Applicable  
polypeptide ENSMUSP00000041878 Ensembl | MGI Sequence Detail 214 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 24
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-8909, MGI:2685820, MGI:94933
References
more
  • Summaries
    All 57
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 12
    Phenotypes 27
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:266465 Rout AK, et al., The Structure of Melanoregulin Reveals a Role for Cholesterol Recognition in the Protein's Ability to Promote Dynein Function. Structure. 2018 Oct 2;26(10):1373-1383.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory