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Mreg Gene Detail
Summary
  • Symbol
    Mreg
  • Name
    melanoregulin
  • Synonyms
    dsu, LOC381269, Wdt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151839
    NCBI Gene: 381269
Location & Maps
more
  • Sequence Map
    Chr1:72159442-72212307 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52866 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MREG, melanoregulin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MREG, melanoregulin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DSU, WDT2
  • Links
    NCBI Gene ID: 55686
    neXtProt AC: NX_Q8N565

  • Chr Location
    2q35; chr2:215942590-216013623 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9954
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: MREG
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from multigenic genotypes
    3 images
    25 phenotype references
  • All Mutations and Alleles
    201
  • Chemically induced (other)
    1
  • Gene trapped
    195
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Mreg
  • Incidental Mutations
A spontaneous suppressor mutation restores normal melanocyte morphology and therefore coat color in mutations producing coat color dilution.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049069 VEGA Gene Model | MGI Sequence Detail 52866 C57BL/6J ±  kb
transcript OTTMUST00000125321 VEGA | MGI Sequence Detail 2284 Not Applicable  
polypeptide OTTMUSP00000067977 VEGA | MGI Sequence Detail 214 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    327 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 25
    cDNA 23
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-8909, MGI:2685820, MGI:94933
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 7
    Phenotypes 25
  • Earliest
    J:7171 Sweet HO, Dilute suppressor, a new suppressor gene in the house mouse. J Hered. 1983 Jul-Aug;74(4):305-6
  • Latest
    J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory