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Mreg
Gene Detail
Symbol

Name
ID
Mreg
melanoregulin
MGI:2151839
Synonyms
dsu, LOC381269, Wdt2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
36.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:72159442-72212307 bp, - strand
From VEGA annotation of GRCm38

  52866 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: MREG
Gene Tree: Mreg

Human
homologs
MREG, melanoregulin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55686
neXtProt AC: NX_Q8N565

Human Synonyms: DSU, WDT2

Human Chr (Location): 2q35; chr2:215942590-216013623 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(199) : Gene trapped(195) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
A spontaneous suppressor mutation restores normal melanocyte morphology and therefore coat color in mutations producing coat color dilution.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Mreg interacts with 193 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process anagen, developmental pigmentation, ...
Component melanosome, membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (18)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Northern blot 22
RT-PCR 3
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mreg    NEW 
Molecular
reagents
All nucleic(25) cDNA(23) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000049069 (Evidence)
Ensembl Gene Model ENSMUSG00000039395 (Evidence)
Entrez Gene 381269 (Evidence)
UniGene 422636
DFCI TC1662645, TC1584937
DoTS DT.102556178
NIA Mouse Gene Index U021459
Consensus CDS Project CCDS15032.1
International Mouse Phenotyping Consortium Status Mreg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049069 VEGA Gene Model | MGI Sequence Detail 52866 C57BL/6J ±  kb
transcript OTTMUST00000125321 VEGA | MGI Sequence Detail 2284 Not Applicable 
polypeptide OTTMUSP00000067977 VEGA | MGI Sequence Detail 214 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(328 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000010563 melanoregulin
References
(Earliest) J:7171 Sweet HO, Dilute suppressor, a new suppressor gene in the house mouse. J Hered. 1983 Jul-Aug;74(4):305-6
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(50)
Other
accession IDs
MGD-MRK-8909, MGI:2685820, MGI:94933

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory