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Tgs1 Gene Detail
Summary
  • Symbol
    Tgs1
  • Name
    trimethylguanosine synthase 1
  • Synonyms
    D4Ertd800e, Ncoa6ip, Pimt
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151797
    NCBI Gene: 116940
  • Gene Overview
    MyGene.info: TGS1
Location & Maps
more
  • Genetic Map
    Chromosome 4, 1.99 cM, cytoband A1
  • Mapping Data
    3 experiments
Homology
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  • Human Ortholog
    TGS1, trimethylguanosine synthase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TGS1, trimethylguanosine synthase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NCOA6IP, PIMT, PIPMT
  • Links
    NCBI Gene ID: 96764
    neXtProt AC: NX_Q96RS0

  • Chr Location
    8q12.1; chr8:55773232-55825448 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32608
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TGS1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    3
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a null mutation display complete lethality around implantation with embryonic growth arrest, impaired hatching from the zona pellucida, and increased apoptosis. Null MEFs display G2 arrest.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004256 VEGA Gene Model | MGI Sequence Detail 41745 C57BL/6J ±  kb
transcript OTTMUST00000009636 VEGA | MGI Sequence Detail 4327 Not Applicable  
polypeptide OTTMUSP00000004654 VEGA | MGI Sequence Detail 853 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    160 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 105
    cDNA 102
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
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MGI:1289226
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:189008 Jia Y, et al., Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene. Mech Dev. 2012 Sep;129(9-12):193-207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory