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Tgs1 Gene Detail
Summary
  • Symbol
    Tgs1
  • Name
    trimethylguanosine synthase 1
  • Synonyms
    D4Ertd800e, Ncoa6ip, Pimt
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151797
    NCBI Gene: 116940
  • Gene Overview
    MyGene.info: TGS1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:3574875-3616619 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 1.99 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151797
protein coding gene Chr4:3574875-3616624 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028022
protein coding gene Chr4:38558-80859 (+)
A/J MGP_AJ_G0027980
protein coding gene Chr4:52260-95356 (+)
AKR/J MGP_AKRJ_G0027946
protein coding gene Chr4:41970-83221 (+)
BALB/cJ MGP_BALBcJ_G0027992
protein coding gene Chr4:33546-75712 (+)
C3H/HeJ MGP_C3HHeJ_G0027722
protein coding gene Chr4:197163-237532 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028435
protein coding gene Chr4:120554-167216 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025779
protein coding gene Chr4:33494-75132 (+)
CAST/EiJ MGP_CASTEiJ_G0027175
protein coding gene Chr4:48206-89738 (+)
CBA/J MGP_CBAJ_G0027697
protein coding gene Chr4:39833-80803 (+)
DBA/2J MGP_DBA2J_G0027837
protein coding gene Chr4:51147-92187 (+)
FVB/NJ MGP_FVBNJ_G0027804
protein coding gene Chr4:24933-65949 (+)
LP/J MGP_LPJ_G0027948
protein coding gene Chr4:90069-132843 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027837
protein coding gene Chr4:190164-239882 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028494
protein coding gene Chr4:46573-89477 (+)
PWK/PhJ MGP_PWKPhJ_G0026898
protein coding gene Chr4:188487-230479 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026727
protein coding gene Chr4:39698-81007 (+)
WSB/EiJ MGP_WSBEiJ_G0027255
protein coding gene Chr4:144775-185684 (+)



Homology
more
  • Human Ortholog
    TGS1, trimethylguanosine synthase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TGS1, trimethylguanosine synthase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NCOA6IP, PIMT, PIPMT
  • Links
    NCBI Gene ID: 96764
    neXtProt AC: NX_Q96RS0
    UniProt: Q96RS0

  • Chr Location
    8q12.1; chr8:55773232-55826445 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32608
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TGS1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display complete lethality around implantation with embryonic growth arrest, impaired hatching from the zona pellucida, and increased apoptosis. Null MEFs display G2 arrest.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028233 Ensembl Gene Model | MGI Sequence Detail 41745 C57BL/6J ±  kb
    transcript ENSMUST00000052712 Ensembl | MGI Sequence Detail 4327 Not Applicable  
    polypeptide ENSMUSP00000054112 Ensembl | MGI Sequence Detail 853 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 103
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1289226
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:241367 Carroll SH, et al., Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in beta-adrenergic receptor signaling. PLoS One. 2017;12(3):e0173823

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory