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Tgs1
Gene Detail
Symbol

Name
ID
Tgs1
trimethylguanosine synthase homolog (S. cerevisiae)
MGI:2151797
Synonyms
D4Ertd800e, Ncoa6ip, Pimt
Feature Type
protein coding gene
Genetic Map
Chromosome 4
1.99 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:3574875-3616619 bp, + strand
From VEGA annotation of GRCm38

  41745 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32608  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TGS1
Gene Tree: Tgs1

Human
homologs
TGS1, trimethylguanosine synthase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 96764
neXtProt AC: NX_Q96RS0

Human Synonyms: NCOA6IP, PIMT, PIPMT

Human Chr (Location): 8q11; chr8:55773232-55825448 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display complete lethality around implantation with embryonic growth arrest, impaired hatching from the zona pellucida, and increased apoptosis. Null MEFs display G2 arrest.
 
Interactions
Tgs1 interacts with 274 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (69)    Tissues (45)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 23
Western blot 6
RT-PCR 16
cDNA source data(102)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tgs1    NEW 
Molecular
reagents
All nucleic(105) cDNA(102) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000004256 (Evidence)
Ensembl Gene Model ENSMUSG00000028233 (Evidence)
Entrez Gene 116940 (Evidence)
UniGene 171323
DFCI TC1575707, TC1613975
DoTS DT.91338523, DT.528056, DT.524279, DT.99777978
NIA Mouse Gene Index U004031
EC 2.1.1.-
Consensus CDS Project CCDS17938.1
International Mouse Phenotyping Consortium Status Tgs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004256 VEGA Gene Model | MGI Sequence Detail 41745 C57BL/6J ±  kb
transcript OTTMUST00000009636 VEGA | MGI Sequence Detail 4327 Not Applicable 
polypeptide OTTMUSP00000004654 VEGA | MGI Sequence Detail 853 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019012 RNA cap guanine-N2 methyltransferase
Protein Ontology PR:000016300 trimethylguanosine synthase
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:189008 Jia Y, et al., Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene. Mech Dev. 2012 Sep;129(9-12):193-207
All references(40)
Other
accession IDs
MGI:1289226

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory