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Derl2
Gene Detail
Symbol

Name
ID
Derl2
Der1-like domain family, member 2
MGI:2151483
Synonyms
CGI-101, Derlin-2, Flana, F-lana, MGC:11613
Feature Type
protein coding gene
Genetic Map
Chromosome 11
43.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:71007164-71019841 bp, - strand
From VEGA annotation of GRCm38

  12678 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9356  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DERL2
Gene Tree: Derl2

Human
homologs
DERL2, derlin 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51009
neXtProt AC: NX_Q9GZP9

Human Synonyms: CGI-101, DERtrin-2, F-LAN-1, FLANa, F-LANa

Human Chr (Location): 17p13.2; chr17:5471251-5486512 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(9) Targeted(6)
Genomic Mutations involving Derl2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit partial neonatal lethality with surviving mice exhibiting male sterility, inverted rib cage, abnormal chondrocytes in the ribs, lethality during pregancy, cachexia, and premature death.
 
Interactions
Derl2 interacts with 314 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process endoplasmic reticulum unfolded protein response, ER-associated ubiquitin-dependent protein catabolic process, ...
Component cell, cytoplasm, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase derl2 ; ZFIN derl2    NEW 
Molecular
reagents
All nucleic(15) Genomic(2) cDNA(13)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006077 (Evidence)
Ensembl Gene Model ENSMUSG00000018442 (Evidence)
Entrez Gene 116891 (Evidence)
DFCI TC1602213, TC1613349, TC1576599
NIA Mouse Gene Index U033014, U164241
Consensus CDS Project CCDS24972.1, CCDS70235.1
International Mouse Phenotyping Consortium Status Derl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006077 VEGA Gene Model | MGI Sequence Detail 12678 C57BL/6J ±  kb
transcript OTTMUST00000013719 VEGA | MGI Sequence Detail 884 Not Applicable 
polypeptide OTTMUSP00000006361 VEGA | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007599 Derlin
Protein Ontology PR:000006423 derlin-2
References
(Earliest) J:69530 Watters JW, et al., Genetic, physical, and transcript map of the ltxs1 region of mouse chromosome 11. Genomics. 2001 Apr 15;73(2):223-31
(Latest) J:215393 Yamamoto S, et al., Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. Dev Biol. 2014 Sep 1;393(1):33-43
All references(37)
Other
accession IDs
MGI:2136260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory