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Derl2
Gene Detail
 Symbol
Name
ID
Derl2
Der1-like domain family, member 2
MGI:2151483
Synonyms CGI-101, Derlin-2, Flana, F-lana, MGC:11613
Feature Type protein coding gene
Genetic Map
Chromosome 11
43.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:71007164-71019841 bp, - strand
From VEGA annotation of GRCm38

  12678 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9356  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Derl2

Human
homologs
Human Homolog DERL2, derlin 2
NCBI Gene ID 51009
neXtProt AC  NX_Q9GZP9
Human Synonyms  F-LAN-1, FLANa, F-LANa
Human Chr (Location)  17p13.2; chr17:5474285-5486498 (-)  GRCh38
Alleles
and
phenotypes
All alleles(13) : Gene trapped(9) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit partial neonatal lethality with surviving mice exhibiting male sterility, inverted rib cage, abnormal chondrocytes in the ribs, lethality during pregancy, cachexia, and premature death.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process endoplasmic reticulum unfolded protein response, ER-associated ubiquitin-dependent protein catabolic process, ...
Component cell, early endosome, ...
Function molecular_function
External Resources: FuncBase
Expression
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) Genomic(2) cDNA(13)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000006077 (Evidence)
Ensembl Gene ModelENSMUSG00000018442 (Evidence)
Entrez Gene116891 (Evidence)
DFCITC1576599, TC1602213, TC1613349
NIA Mouse Gene IndexU033014, U164241
Consensus CDS ProjectCCDS24972.1, CCDS70235.1
International Mouse Knockout Project StatusDerl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006077 VEGA Gene Model | MGI Sequence Detail 12678 C57BL/6J ±  kb
transcript OTTMUST00000013719 VEGA | MGI Sequence Detail 884 Not Applicable 
polypeptide OTTMUSP00000006361 VEGA | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(8) UniProt(5)
Polymorphisms SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007599 Derlin
Protein Ontology PR:000006423 derlin-2
References (Earliest) J:69530 Watters JW, et al., Genetic, physical, and transcript map of the ltxs1 region of mouse chromosome 11. Genomics. 2001 Apr 15;73(2):223-31
(Latest) J:200660 Tiwari A, et al., SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic beta-cells. J Cell Sci. 2013 May 1;126(Pt 9):1962-8
All references(37)
Other
accession IDs
MGI:2136260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory