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Derl2 Gene Detail
Summary
  • Symbol
    Derl2
  • Name
    Der1-like domain family, member 2
  • Synonyms
    CGI-101, Derlin-2, Flana, F-lana, MGC:11613
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151483
    NCBI Gene: 116891
  • Gene Overview
    MyGene.info: DERL2
Location & Maps
more
  • Sequence Map
    Chr11:71007164-71019841 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12678 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.21 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    DERL2, derlin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DERL2, derlin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGI-101, DERtrin-2, F-LAN-1, FLANa, F-LANa
  • Links
    NCBI Gene ID: 51009
    neXtProt AC: NX_Q9GZP9

  • Chr Location
    17p13.2; chr17:5471251-5486512 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9356
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DERL2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    9
  • Targeted
    6
  • Genomic Mutations
    2 involving Derl2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit partial neonatal lethality with surviving mice exhibiting male sterility, inverted rib cage, abnormal chondrocytes in the ribs, lethality during pregancy, cachexia, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006077 VEGA Gene Model | MGI Sequence Detail 12678 C57BL/6J ±  kb
transcript OTTMUST00000013719 VEGA | MGI Sequence Detail 884 Not Applicable  
polypeptide OTTMUSP00000006361 VEGA | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    109 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 15
    Genomic 2
    cDNA 13

    Microarray probesets 5
Other
Accession IDs
less
MGI:2136260
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:69530 Watters JW, et al., Genetic, physical, and transcript map of the ltxs1 region of mouse chromosome 11. Genomics. 2001 Apr 15;73(2):223-31
  • Latest
    J:215393 Yamamoto S, et al., Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. Dev Biol. 2014 Sep 1;393(1):33-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory