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Derl2 Gene Detail
Summary
  • Symbol
    Derl2
  • Name
    Der1-like domain family, member 2
  • Synonyms
    CGI-101, Derlin-2, Flana, F-lana, MGC:11613
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151483
    NCBI Gene: 116891
  • Gene Overview
    MyGene.info: DERL2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:71007440-71019841 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.21 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151483
protein coding gene Chr11:71007164-71019841 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018622
protein coding gene Chr11:71583061-71597582 (-)
A/J MGP_AJ_G0018590
protein coding gene Chr11:68862901-68876098 (-)
AKR/J MGP_AKRJ_G0018559
protein coding gene Chr11:70939049-70951094 (-)
BALB/cJ MGP_BALBcJ_G0018562
protein coding gene Chr11:69173102-69185502 (-)
C3H/HeJ MGP_C3HHeJ_G0018375
protein coding gene Chr11:70974307-70987931 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019013
protein coding gene Chr11:73752420-73764463 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016658
protein coding gene Chr11:65768587-65780634 (-)
CAST/EiJ MGP_CASTEiJ_G0017930
protein coding gene Chr11:71245316-71257694 (-)
CBA/J MGP_CBAJ_G0018347
protein coding gene Chr11:77076820-77089423 (-)
DBA/2J MGP_DBA2J_G0018457
protein coding gene Chr11:68442965-68455048 (-)
FVB/NJ MGP_FVBNJ_G0018447
protein coding gene Chr11:68086607-68098650 (-)
LP/J MGP_LPJ_G0018527
protein coding gene Chr11:72169996-72182038 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018470
protein coding gene Chr11:77613935-77626214 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019055
protein coding gene Chr11:71196246-71209479 (-)
PWK/PhJ MGP_PWKPhJ_G0017704
protein coding gene Chr11:69098101-69110538 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017494
protein coding gene Chr11:71006045-71021553 (-)
WSB/EiJ MGP_WSBEiJ_G0017984
protein coding gene Chr11:70861307-70873327 (-)



Homology
more
  • Human Ortholog
    DERL2, derlin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DERL2, derlin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-101, derlin-2, DERtrin-2, F-LAN-1, FLANa, F-LANa
  • Links
    NCBI Gene ID: 51009
    neXtProt AC: NX_Q9GZP9
    UniProt: Q9GZP9

  • Chr Location
    17p13.2; chr17:5471251-5486230 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9356
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DERL2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial neonatal lethality with surviving mice exhibiting male sterility, inverted rib cage, abnormal chondrocytes in the ribs, lethality during pregancy, cachexia, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 116891 NCBI Gene Model | MGI Sequence Detail 12402 C57BL/6J ±  kb
transcript NM_001291146 RefSeq | MGI Sequence Detail 3959 C57BL/6  
polypeptide Q8BNI4 UniProt | EBI | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 2
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
less
MGI:2136260
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 18
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory