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Calca
Gene Detail
Symbol

Name
ID
Calca
calcitonin/calcitonin-related polypeptide, alpha
MGI:2151253
Synonyms
alpha CGRP, CA, Calc, Cgrp, Ct, CT, Ctn
Feature Type
protein coding gene
Genetic Map
Chromosome 7
59.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr7:114631480-114636357 bp, - strand
From Ensembl annotation of GRCm38

  4878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88337  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: CALCA, CALCB
Protein SuperFamily: calcitonin/calcitonin gene-related protein/amylin
Gene Tree: Calca

Human
homologs
CALCA, calcitonin-related polypeptide alpha
Orthology source: HGNC

IDs:
NCBI Gene ID: 796
neXtProt AC: NX_P01258, NX_P06881

Human Synonyms: CALC1, CGRP, CGRP1, CGRP-I, CT, KC

Human Chr (Location): 11p15.2; chr11:14966669-14972286 (-)  GRCh38.p2

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
 
Two separate peptides, calcitonin and calcitonin gene related peptide-alpha (CGRP-alpha), are derived from this locus by alternative splicing. Mice homozygous null for CGRP-alpha have changes in the vascular and nervous system. Mice lacking calcitonin have increased bone mineralization.
 
Interactions
Calca interacts with 124 markers (Mir22, Mir34a, Mir34b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (161 records)
Data Summary: Results (101)    Tissues (47)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 84
RNA in situ 17
cDNA source data(35)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000030669 (Evidence)
Entrez Gene 12310 (Evidence)
UniGene 4361
DFCI TC1584330, TC1585668, TC1679437
DoTS DT.87033494, DT.491467, DT.102556754, DT.94228656
NIA Mouse Gene Index U029153
Consensus CDS Project CCDS21762.1, CCDS21763.1
International Mouse Phenotyping Consortium Status Calca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030669 Ensembl Gene Model | MGI Sequence Detail 4878 C57BL/6J ±  kb
transcript ENSMUST00000032907 Ensembl | MGI Sequence Detail 870 Not Applicable 
polypeptide ENSMUSP00000032907 Ensembl | MGI Sequence Detail 136 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(13) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018360 Calcitonin, conserved site
InterPro IPR001693 Calcitonin peptide-like
InterPro IPR021116 Procalcitonin/adrenomedullin
InterPro IPR021118 Procalcitonin, alpha type
InterPro IPR015476 Procalcitonin gene-related peptide, proCGRP
InterPro IPR021117 Procalcitonin-like
Protein Ontology PR:000027222 calcitonin
References
(Earliest) J:6525 Jacobs JW, et al., Calcitonin messenger RNA encodes multiple polypeptides in a single precursor. Science. 1981 Jul 24;213(4506):457-9
(Latest) J:221589 Szabo NE, et al., Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception. J Neurosci. 2015 Apr 1;35(13):5233-46
All references(283)
Other
accession IDs
MGD-MRK-1732, MGD-MRK-2210, MGD-MRK-2239, MGI:1101063, MGI:88249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory