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Calca
Gene Detail
Symbol

Name
ID
Calca
calcitonin/calcitonin-related polypeptide, alpha
MGI:2151253
Synonyms
alpha CGRP, CA, Calc, Cgrp, Ct, CT, Ctn
Feature Type
protein coding gene
Genetic Map
Chromosome 7
59.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr7:114631480-114636357 bp, - strand
From Ensembl annotation of GRCm38

  4878 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88337  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: calcitonin/calcitonin gene-related protein/amylin
Gene Tree: Calca

Human
homologs
Human Homolog CALCB, calcitonin-related polypeptide beta
NCBI Gene ID 797
neXtProt AC  NX_P10092
Human Synonyms  CALC2, CGRP2, CGRP-II
Human Chr (Location)  11p15.2-p15.1; chr11:15073597-15082342 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
 
Two separate peptides, calcitonin and calcitonin gene related peptide-alpha (CGRP-alpha), are derived from this locus by alternative splicing. Mice homozygous null for CGRP-alpha have changes in the vascular and nervous system. Mice lacking calcitonin have increased bone mineralization.
 
Interactions
Calca interacts with 125 markers (Mir22, Mir34a, Mir34b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (158 records)
Data Summary: Results (101)    Tissues (47)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 84
RNA in situ 17
cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000030669 (Evidence)
Entrez Gene12310 (Evidence)
UniGene4361
DFCITC1584330, TC1585668, TC1679437
DoTSDT.102556754, DT.87033494, DT.94228656, DT.491467
NIA Mouse Gene IndexU029153
Consensus CDS ProjectCCDS21762.1, CCDS21763.1
International Mouse Knockout Project StatusCalca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030669 Ensembl Gene Model | MGI Sequence Detail 4878 C57BL/6J ±  kb
transcript ENSMUST00000032907 Ensembl | MGI Sequence Detail 870 Not Applicable 
polypeptide ENSMUSP00000032907 Ensembl | MGI Sequence Detail 136 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(10) UniProt(4)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018360 Calcitonin, conserved site
InterPro IPR001693 Calcitonin peptide-like
InterPro IPR021116 Procalcitonin/adrenomedullin
InterPro IPR021118 Procalcitonin, alpha type
InterPro IPR015476 Procalcitonin gene-related peptide, proCGRP
InterPro IPR021117 Procalcitonin-like
Protein Ontology PR:000027222 calcitonin
References
(Earliest) J:6525 Jacobs JW, et al., Calcitonin messenger RNA encodes multiple polypeptides in a single precursor. Science. 1981 Jul 24;213(4506):457-9
(Latest) J:213126 O'Donovan KJ, et al., B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med. 2014 May 5;211(5):801-14
All references(280)
Other
accession IDs
MGD-MRK-1732, MGD-MRK-2210, MGD-MRK-2239, MGI:1101063, MGI:88249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory