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Calca Gene Detail
Summary
  • Symbol
    Calca
  • Name
    calcitonin/calcitonin-related polypeptide, alpha
  • Synonyms
    alpha CGRP, CA, Calc, Cgrp, Ct, CT, Ctn
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151253
    NCBI Gene: 12310
  • Gene Overview
    MyGene.info: CALCA
Location & Maps
more
  • Sequence Map
    Chr7:114631478-114636357 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4880 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 59.99 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    CALCA, calcitonin related polypeptide alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CALCA, calcitonin related polypeptide alpha
    Orthology source: HGNC
  • Synonyms
    CALC1, CGRP, CGRP1, CGRP-I, CT, KC, PCT
  • Links
    NCBI Gene ID: 796
    neXtProt AC: NX_P01258, NX_P06881

  • Chr Location
    11p15.2; chr11:14966669-14972286 (-)  GRCh38.p2

  • Human Ortholog
    CALCB, calcitonin related polypeptide beta
    Orthology source: HomoloGene
  • Synonyms
    CALC2, CGRP2, CGRP-II
  • Links
    NCBI Gene ID: 797
    neXtProt AC: NX_P10092

  • Chr Location
    11p15.2; chr11:15073600-15078631 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 6 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    1 involving Calca
Two separate peptides, calcitonin and calcitonin gene related peptide-alpha (CGRP-alpha), are derived from this locus by alternative splicing. Mice homozygous null for CGRP-alpha have changes in the vascular and nervous system. Mice lacking calcitonin have increased bone mineralization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058696 VEGA Gene Model | MGI Sequence Detail 4880 C57BL/6J ±  kb
transcript OTTMUST00000144181 VEGA | MGI Sequence Detail 830 Not Applicable  
polypeptide OTTMUSP00000075179 VEGA | MGI Sequence Detail 136 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    68 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1732, MGD-MRK-2210, MGD-MRK-2239, MGI:1101063, MGI:88249
References
more
  • Summaries
    All 300
    Developmental Gene Expression 175
    Gene Ontology 36
    Phenotypes 60
  • Earliest
    J:6525 Jacobs JW, et al., Calcitonin messenger RNA encodes multiple polypeptides in a single precursor. Science. 1981 Jul 24;213(4506):457-9
  • Latest
    J:233896 Hibberd TJ, et al., Identification of different functional types of spinal afferent neurons innervating the mouse large intestine using a novel CGRPalpha transgenic reporter mouse. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 15;310(8):G561-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory