About   Help   FAQ
Calca Gene Detail
Summary
  • Symbol
    Calca
  • Name
    calcitonin/calcitonin-related polypeptide, alpha
  • Synonyms
    alpha CGRP, CA, Calc, Cgrp, Ct, CT, Ctn
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151253
    NCBI Gene: 12310
  • Gene Overview
    MyGene.info: CALCA
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:114631478-114636357 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 59.99 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151253
protein coding gene Chr7:114625903-114636460 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032884
protein coding gene Chr7:118306167-118311008 (-)
A/J MGP_AJ_G0032867
protein coding gene Chr7:115337686-115342539 (-)
AKR/J MGP_AKRJ_G0032799
protein coding gene Chr7:118255577-118260430 (-)
BALB/cJ MGP_BALBcJ_G0032872
protein coding gene Chr7:115039116-115043969 (-)
C3H/HeJ MGP_C3HHeJ_G0032582
protein coding gene Chr7:118224145-118229002 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033378
protein coding gene Chr7:123055481-123060342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030350
protein coding gene Chr7:116862701-116867521 (-)
CAST/EiJ MGP_CASTEiJ_G0031910
protein coding gene Chr7:109871248-109876110 (-)
CBA/J MGP_CBAJ_G0032555
protein coding gene Chr7:127156117-127160972 (-)
DBA/2J MGP_DBA2J_G0032707
protein coding gene Chr7:113386218-113391105 (-)
FVB/NJ MGP_FVBNJ_G0032660
protein coding gene Chr7:113255135-113259980 (-)
LP/J MGP_LPJ_G0032801
protein coding gene Chr7:119817151-119822014 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032692
protein coding gene Chr7:128764639-128769492 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033398
protein coding gene Chr7:117231456-117236311 (-)
PWK/PhJ MGP_PWKPhJ_G0031618
protein coding gene Chr7:106265115-106269975 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031465
protein coding gene Chr7:103973721-103978556 (-)
WSB/EiJ MGP_WSBEiJ_G0032023
protein coding gene Chr7:118096413-118101242 (-)



Homology
more
  • Human Ortholog
    CALCA, calcitonin related polypeptide alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CALCA, calcitonin related polypeptide alpha
    Orthology source: HGNC
  • Synonyms
    CALC1, CGRP, CGRP1, CGRP-I, CT, KC, PCT
  • Links
    NCBI Gene ID: 796
    neXtProt AC: NX_P01258, NX_P06881
    UniProt: P01258, P06881

  • Chr Location
    11p15.2; chr11:14966668-14972361 (-)  GRCh38.p7

  • Human Ortholog
    CALCB, calcitonin related polypeptide beta
    Orthology source: HomoloGene
  • Synonyms
    CALC2, CGRP2, CGRP-II
  • Links
    NCBI Gene ID: 797
    neXtProt AC: NX_P10092
    UniProt: P10092

  • Chr Location
    11p15.2; chr11:15073600-15078631 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 6 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Two separate peptides, calcitonin and calcitonin gene related peptide-alpha (CGRP-alpha), are derived from this locus by alternative splicing. Mice homozygous null for CGRP-alpha have changes in the vascular and nervous system. Mice lacking calcitonin have increased bone mineralization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030669 Ensembl Gene Model | MGI Sequence Detail 4880 C57BL/6J ±  kb
    transcript ENSMUST00000032907 Ensembl | MGI Sequence Detail 830 Not Applicable  
    polypeptide ENSMUSP00000032907 Ensembl | MGI Sequence Detail 136 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 39
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1732, MGD-MRK-2210, MGD-MRK-2239, MGI:1101063, MGI:88249
    References
    more
    • Summaries
      All 351
      Developmental Gene Expression 190
      Gene Ontology 37
      Phenotypes 71
    • Earliest
      J:6525 Jacobs JW, et al., Calcitonin messenger RNA encodes multiple polypeptides in a single precursor. Science. 1981 Jul 24;213(4506):457-9
    • Latest
      J:264403 Li Q, et al., Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling. J Cell Sci. 2018 Jul 25;131(14)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory