Selenon MGI Mouse Gene Detail - MGI:2151208

Symbol

Selenon
Name

selenoprotein N
Synonyms

1110019I12Rik, Sepn1

Feature Type

protein coding gene
IDs

MGI:2151208
NCBI Gene: 74777
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:134265203-134279477 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.85 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

565 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151208	protein coding gene	Chr4:134265203-134279477 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028931	protein coding gene	Chr4:136899624-136915588 (-)
A/J	MGP_AJ_G0028890	protein coding gene	Chr4:131141389-131156616 (-)
AKR/J	MGP_AKRJ_G0028842	protein coding gene	Chr4:134906789-134921101 (-)
BALB/cJ	MGP_BALBcJ_G0028914	protein coding gene	Chr4:131788974-131803280 (-)
C3H/HeJ	MGP_C3HHeJ_G0028628	protein coding gene	Chr4:135150279-135164591 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029355	protein coding gene	Chr4:141839365-141855213 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026626	protein coding gene	Chr4:124196546-124210995 (-)
CAST/EiJ	MGP_CASTEiJ_G0028060	protein coding gene	Chr4:133267380-133281724 (-)
CBA/J	MGP_CBAJ_G0028593	protein coding gene	Chr4:145584501-145604935 (-)
DBA/2J	MGP_DBA2J_G0028742	protein coding gene	Chr4:131562390-131577069 (-)
FVB/NJ	MGP_FVBNJ_G0028709	protein coding gene	Chr4:130461952-130476189 (-)
LP/J	MGP_LPJ_G0028841	protein coding gene	Chr4:137011772-137026120 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028735	protein coding gene	Chr4:150055005-150070846 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029393	protein coding gene	Chr4:135344405-135358792 (-)
PWK/PhJ	MGP_PWKPhJ_G0027780	protein coding gene	Chr4:128293907-128309967 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027606	protein coding gene	Chr4:131157627-131172071 (-)
WSB/EiJ	MGP_WSBEiJ_G0028138	protein coding gene	Chr4:135509143-135526172 (-)

Human Ortholog

SELENON, selenoprotein N

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SELENON, selenoprotein N
Synonyms

CFTD, CMYO3, CMYP3, MDRS1, RSMD1, RSS, SELN, SEPN1
Links

HGNC:15999

NCBI Gene ID: 57190

UniProt: Q9NZV5
Chr Location

1p36.11; chr1:25800193-25818221 (+) GRCh38

MGI Vertebrate Homology

Selenon stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SELENON
Gene Tree

Selenon

Diseases

1 with Selenon mouse models; 1 with human SELENON associations

Human Disease

Mouse Models

rigid spine muscular dystrophy 1

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

30 phenotypes from 4 alleles in 5 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

1
Targeted

6
Genomic Mutations

3 involving Selenon
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit satellite cell loss and impaired muscle regeneration. Mice homozygous for a different knock-out allele exhibit subtle core lesions in skeletal muscle after induced oxidative stress and abnormal lung development.

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All GO Annotations

46
GO References

10

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

871
Tissues

55
cDNA Data

76
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SELENON

Xenbase selenon

ZFIN selenon

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All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS38917.1

Ensembl

ENSMUSG00000050989 (Evidence)
NCBI Gene

74777

			Length	Strain/Species	Flank
genomic	74777	NCBI Gene Model \| MGI Sequence Detail	14275	C57BL/6J	± kb
transcript	NM_029100	RefSeq \| MGI Sequence Detail	3461	C57BL/6
polypeptide	D3Z2R5	UniProt \| EBI \| MGI Sequence Detail	557	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014645 selenoprotein N

(term hierarchy)
InterPro Domains

IPR002048 EF-hand domain
GlyGen

D3Z2R5 3 sites, 1 N-linked glycan (1 site)

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All nucleic 79

cDNA 76

Primer pair 3

Microarray probesets 3

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MGI:1922027, MGI:2140256

Summaries

All 46

Developmental Gene Expression 2

Diseases 1

Gene Ontology 10

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:356241 Germani S, et al., SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA. Cell Rep Med. 2024 Mar 19;5(3):101439

TSS for Selenon:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43916	Chr4:134279433-134279511 (-)	5 bp
Tssr43915	Chr4:134275525-134275539 (-)	3,945 bp
Tssr43914	Chr4:134275494-134275506 (-)	3,977 bp
Tssr43913	Chr4:134275462-134275473 (-)	4,009 bp
Tssr43912	Chr4:134275385-134275396 (-)	4,086 bp
Tssr43911	Chr4:134268193-134268199 (-)	11,281 bp
Tssr43910	Chr4:134265928-134265945 (-)	13,540 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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