Sepn1
Gene Detail

Symbol Name ID

Sepn1 selenoprotein N, 1 MGI:2151208

Synonyms

1110019I12Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 4

66.85 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:134537892-134552166 bp, - strand From VEGA annotation of GRCm38   14275 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10723  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sepn1

Human homologs

Human Homolog		SEPN1, selenoprotein N, 1
NCBI Gene ID		57190
neXtProt AC		NX_Q9NZV5
Human Synonyms		CFTD, MDRS1, RSMD1, RSS, SELN
Human Chr (Location)		1p36.13; chr1:26126667-26144713 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SEPN1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit satellite cell loss and impaired muscle regeneration.

 
Human Diseases Modeled Using Mouse Sepn1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	multicellular organismal response to stress, positive regulation of skeletal muscle cell proliferation, ...
Component	cellular_component
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (165)    Tissues (49)    Images (31)
Theiler Stages: 7, 11, 13, 15, 17, 19, 20, 21, 23, 26, 28

Assay Type	Results
RNA in situ	55
Northern blot	2
Western blot	42
RT-PCR	66

cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(78) cDNA(75) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000011213 (Evidence)
Ensembl Gene Model	ENSMUSG00000050989 (Evidence)
Entrez Gene	74777 (Evidence)
UniGene	29773
DFCI	TC1576602, TC1627890, TC1630744, TC1678699
DoTS	DT.110790954, DT.532817, DT.94373166
NIA Mouse Gene Index	U025644
Consensus CDS Project	CCDS38917.1
International Mouse Knockout Project Status	Sepn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011213	VEGA Gene Model | MGI Sequence Detail	14275	C57BL/6J
transcript	OTTMUST00000026309	VEGA | MGI Sequence Detail	3445	Not Applicable
polypeptide	OTTMUSP00000012033	VEGA | MGI Sequence Detail	557	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(64 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002048	EF-hand domain

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:176499 Rederstorff M, et al., Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. PLoS One. 2011;6(8):e23094
All references(34)

Other accession IDs

MGI:1922027, MGI:2140256