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Sepn1
Gene Detail
 Symbol
Name
ID
Sepn1
selenoprotein N, 1
MGI:2151208
Synonyms 1110019I12Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
66.85 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:134537892-134552166 bp, - strand
From VEGA annotation of GRCm38

  14275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10723  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sepn1

Human
homologs
Human Homolog SEPN1, selenoprotein N, 1
NCBI Gene ID 57190
neXtProt AC  NX_Q9NZV5
Human Synonyms  CFTD, MDRS1, RSMD1, RSS, SELN
Human Chr (Location)  1p36.13; chr1:25800176-25818222 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SEPN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit satellite cell loss and impaired muscle regeneration. Mice homozygous for a different knock-out allele exhibit subtle core lesions in skeletal muscle after induced oxidative stress and abnormal lung development.
 
Human Diseases Modeled Using Mouse Sepn1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sepn1 interacts with 219 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cellular response to caffeine, cellular response to oxidative stress, ...
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (165)    Tissues (55)    Images (31)
Theiler Stages: 7, 11, 13, 15, 17, 19, 20, 21, 23, 26, 27, 28
Assay TypeResults
RNA in situ 55
Northern blot 2
Western blot 42
RT-PCR 66
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(75) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000011213 (Evidence)
Ensembl Gene ModelENSMUSG00000050989 (Evidence)
Entrez Gene74777 (Evidence)
UniGene29773
DFCITC1576602, TC1627890, TC1630744, TC1678699
DoTSDT.110790954, DT.532817, DT.94373166
NIA Mouse Gene IndexU025644
Consensus CDS ProjectCCDS38917.1
International Mouse Knockout Project StatusSepn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011213 VEGA Gene Model | MGI Sequence Detail 14275 C57BL/6J ±  kb
transcript OTTMUST00000026309 VEGA | MGI Sequence Detail 3445 Not Applicable 
polypeptide OTTMUSP00000012033 VEGA | MGI Sequence Detail 557 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:197753 Moghadaszadeh B, et al., Selenoprotein N deficiency in mice is associated with abnormal lung development. FASEB J. 2013 Apr;27(4):1585-99
All references(35)
Disease annotation references (1)
Other
accession IDs
MGI:1922027, MGI:2140256

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory