Mta3 MGI Mouse Gene Detail - MGI:2151172

Mta3 Gene Detail

Symbol

Mta3
Name

metastasis associated 3
Synonyms

1110002J22Rik, mKIAA1266

Feature Type

protein coding gene
IDs

MGI:2151172
NCBI Gene: 116871
Gene Overview

MyGene.info: MTA3

Sequence Map

Chr17:83706163-83821516 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

115354 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 54.53 cM, cytoband E4
Mapping Data

2 experiments

Human Ortholog

MTA3, metastasis associated 1 family member 3

Vertebrate Orthologs

9

Human Ortholog

MTA3, metastasis associated 1 family member 3
Orthology source: HomoloGene, HGNC
Links

HGNC:23784

NCBI Gene ID: 57504

neXtProt AC: NX_Q9BTC8

UniProt: Q9BTC8
Chr Location

2p21; chr2:42494569-42795032 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 14282
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: MTA3
Gene Tree

Mta3

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

278
Gene trapped

273
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

132 strains or lines available

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All GO Annotations

19
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

59
Tissues

59
cDNA Data

19
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MTA3

ZFIN mta3

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Mta3 interacts with 362 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

93
RefSeq

24
UniProt

12
CCDS

CCDS28997.1, CCDS50195.1, CCDS50196.1, CCDS50197.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000017301	VEGA Gene Model \| MGI Sequence Detail	115354	C57BL/6J	± kb
transcript	OTTMUST00000041971	VEGA \| MGI Sequence Detail	2087	Not Applicable
polypeptide	OTTMUSP00000018873	VEGA \| MGI Sequence Detail	591	Not Applicable

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SNPs within 2kb

1145 from dbSNP Build 142

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UniProt

12 Sequences
Protein Ontology

PR:000010709 metastasis-associated protein MTA3

(term hierarchy)
PDB

2CRG
InterPro Domains

IPR001025 Bromo adjacent homology (BAH) domain

IPR000949 ELM2 domain

IPR009057 Homeobox domain-like

IPR017884 SANT domain

IPR001005 SANT/Myb domain

IPR000679 Zinc finger, GATA-type

IPR013088 Zinc finger, NHR/GATA-type

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 6

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MGI:1915798

Summaries

All 44

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:194303 D R D, et al., Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development. Dev Biol. 2013 Mar 15;375(2):105-16

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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