Mta3 MGI Mouse Gene Detail - MGI:2151172

Symbol

Mta3
Name

metastasis associated 3
Synonyms

1110002J22Rik, mKIAA1266

Feature Type

protein coding gene
IDs

MGI:2151172
NCBI Gene: 116871
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr17:84013592-84128945 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 54.53 cM, cytoband E4
Mapping Data

3 experiments

SNPs within 2kb

1145 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151172	protein coding gene	Chr17:84013483-84131144 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024075	protein coding gene	Chr17:86807214-86931418 (+)
A/J	MGP_AJ_G0024034	protein coding gene	Chr17:84066040-84199372 (+)
AKR/J	MGP_AKRJ_G0024003	protein coding gene	Chr17:85433285-85554783 (+)
BALB/cJ	MGP_BALBcJ_G0024035	protein coding gene	Chr17:83938426-84057391 (+)
C3H/HeJ	MGP_C3HHeJ_G0023800	protein coding gene	Chr17:86282132-86408792 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024480	protein coding gene	Chr17:89927456-90049507 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021919	protein coding gene	Chr17:79294634-79409952 (+)
CAST/EiJ	MGP_CASTEiJ_G0023279	protein coding gene	Chr17:87014982-87144139 (+)
CBA/J	MGP_CBAJ_G0023774	protein coding gene	Chr17:93633843-93759080 (+)
DBA/2J	MGP_DBA2J_G0023902	protein coding gene	Chr17:82569959-82688910 (+)
FVB/NJ	MGP_FVBNJ_G0023868	protein coding gene	Chr17:82047784-82166510 (+)
LP/J	MGP_LPJ_G0023986	protein coding gene	Chr17:87561083-87683837 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023896	protein coding gene	Chr17:93774453-93895233 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024525	protein coding gene	Chr17:85918472-86049826 (+)
PWK/PhJ	MGP_PWKPhJ_G0023024	protein coding gene	Chr17:82119079-82240699 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022835	protein coding gene	Chr17:82711195-82829773 (+)
WSB/EiJ	MGP_WSBEiJ_G0023346	protein coding gene	Chr17:86772698-86901686 (+)

Human Ortholog

MTA3, metastasis associated 1 family member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTA3, metastasis associated 1 family member 3
Links

HGNC:23784

NCBI Gene ID: 57504

neXtProt AC: NX_Q9BTC8

UniProt: Q9BTC8
Chr Location

2p21; chr2:42494569-42795032 (+) GRCh38.p7

Alliance of Genome Resources

Mta3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MTA3
Gene Tree

Mta3

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

250
Gene trapped

243
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

134 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

37
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

73
cDNA Data

20
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MTA3

ZFIN mta3

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Mta3 interacts with 362 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

96
RefSeq

26
UniProt

12
CCDS

CCDS28997.1, CCDS50195.1, CCDS50196.1, CCDS50197.1

Ensembl

ENSMUSG00000055817 (Evidence)
NCBI Gene

116871

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055817	Ensembl Gene Model \| MGI Sequence Detail	115354	C57BL/6J	± kb
transcript	ENSMUST00000067826	Ensembl \| MGI Sequence Detail	2087	Not Applicable
polypeptide	ENSMUSP00000068931	Ensembl \| MGI Sequence Detail	591	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000010709 metastasis-associated protein MTA3

(term hierarchy)
PDB

2CRG
InterPro Domains

IPR001025 Bromo adjacent homology (BAH) domain

IPR043151 Bromo adjacent homology (BAH) domain superfamily

IPR000949 ELM2 domain

IPR009057 Homeobox-like domain superfamily

IPR040138 Mesoderm induction early response protein/metastasis-associated protein

IPR035170 Metastasis-associated protein MTA1, R1 domain

IPR017930 Myb domain

IPR017884 SANT domain

IPR001005 SANT/Myb domain

IPR000679 Zinc finger, GATA-type

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All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 6

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MGI:1915798

Summaries

All 56

Developmental Gene Expression 10

Gene Ontology 13

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:319940 Yan L, et al., PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex. Adv Sci (Weinh). 2021 Aug;8(16):e2102060

TSS for Mta3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145992	Chr17:84013320-84013342 (+)	-261 bp
Tssr145993	Chr17:84013566-84013598 (+)	-10 bp
Tssr145994	Chr17:84013599-84013629 (+)	22 bp
Tssr145995	Chr17:84013640-84013689 (+)	73 bp
Tssr145996	Chr17:84036570-84036580 (+)	22,983 bp
Tssr145997	Chr17:84036621-84036631 (+)	23,034 bp
Tssr145998	Chr17:84082914-84082921 (+)	69,326 bp
Tssr145999	Chr17:84082936-84082945 (+)	69,349 bp
Tssr146000	Chr17:84082951-84082968 (+)	69,368 bp
Tssr146001	Chr17:84082985-84083032 (+)	69,417 bp
Tssr146002	Chr17:84083057-84083066 (+)	69,470 bp
Tssr146003	Chr17:84083085-84083096 (+)	69,499 bp
Tssr146004	Chr17:84102793-84102812 (+)	89,211 bp
Tssr146005	Chr17:84102824-84102831 (+)	89,236 bp
Tssr146006	Chr17:84111722-84111746 (+)	98,142 bp
Tssr146007	Chr17:84118076-84118094 (+)	104,493 bp
Tssr146008	Chr17:84118189-84118204 (+)	104,605 bp
Tssr146009	Chr17:84118338-84118359 (+)	104,757 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/14/2022 MGI 6.19