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Stim2 Gene Detail
Summary
  • Symbol
    Stim2
  • Name
    stromal interaction molecule 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151156
    NCBI Gene: 116873
  • Gene Overview
    MyGene.info: STIM2
Location & Maps
more
  • Sequence Map
    Chr5:53998499-54121057 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      122559 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 29.69 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    STIM2, stromal interaction molecule 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STIM2, stromal interaction molecule 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 57620
    neXtProt AC: NX_Q9P246

  • Chr Location
    4p15.2; chr4:26860691-27025381 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32490
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: STIM2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    32 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Gene trapped
    3
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    4 involving Stim2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026433 VEGA Gene Model | MGI Sequence Detail 122559 C57BL/6J ±  kb
transcript OTTMUST00000065374 VEGA | MGI Sequence Detail 4892 Not Applicable  
polypeptide OTTMUSP00000032577 VEGA | MGI Sequence Detail 754 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    789 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000015737 stromal interaction molecule 2
  • InterPro Domains
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
    IPR032393 Stromal interaction molecule, Orai1-activating region
Molecular
Reagents
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  • All nucleic 66
    cDNA 65
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 38
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:224009 Fernandez RA, et al., Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype. Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C581-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory