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Stim2 Gene Detail
Summary
  • Symbol
    Stim2
  • Name
    stromal interaction molecule 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151156
    NCBI Gene: 116873
  • Gene Overview
    MyGene.info: STIM2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:53998523-54121057 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 29.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    789 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151156
protein coding gene Chr5:53998499-54121057 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029557
protein coding gene Chr5:53085941-53216574 (+)
A/J MGP_AJ_G0029525
protein coding gene Chr5:51214359-51340066 (+)
AKR/J MGP_AKRJ_G0029473
protein coding gene Chr5:52966267-53090682 (+)
BALB/cJ MGP_BALBcJ_G0029534
protein coding gene Chr5:51694656-51818646 (+)
C3H/HeJ MGP_C3HHeJ_G0029257
protein coding gene Chr5:53127050-53258072 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029988
protein coding gene Chr5:55241992-55371894 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027228
protein coding gene Chr5:47928890-48047878 (+)
CAST/EiJ MGP_CASTEiJ_G0028665
protein coding gene Chr5:52110740-52241816 (+)
CBA/J MGP_CBAJ_G0029226
protein coding gene Chr5:57007518-57145064 (+)
DBA/2J MGP_DBA2J_G0029372
protein coding gene Chr5:51261483-51391214 (+)
FVB/NJ MGP_FVBNJ_G0029332
protein coding gene Chr5:50588321-50713153 (+)
LP/J MGP_LPJ_G0029457
protein coding gene Chr5:53521892-53662719 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029360
protein coding gene Chr5:58002825-58138737 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030021
protein coding gene Chr5:52462483-52592916 (+)
PWK/PhJ MGP_PWKPhJ_G0028389
protein coding gene Chr5:50328117-50449995 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028223
protein coding gene Chr5:51903416-52083026 (+)
WSB/EiJ MGP_WSBEiJ_G0028746
protein coding gene Chr5:52515413-52643783 (+)



Homology
more
  • Human Ortholog
    STIM2, stromal interaction molecule 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STIM2, stromal interaction molecule 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 57620
    neXtProt AC: NX_Q9P246
    UniProt: Q9P246

  • Chr Location
    4p15.2; chr4:26860691-27025381 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32490
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STIM2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 5 alleles in 5 genetic backgrounds
    32 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a slight growth delay and premature death while embryonic fibroblasts show reduced store-operated Ca2+ influx. Mice homozygous for a different null allele show increased neuron survival under hypoxic conditions and resistance to ischemic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 116873 NCBI Gene Model | MGI Sequence Detail 122535 C57BL/6J ±  kb
transcript NM_001363348 RefSeq | MGI Sequence Detail 4934 C57BL/6  
polypeptide P83093 UniProt | EBI | MGI Sequence Detail 746 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 67
    cDNA 66
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 78
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 50
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:274914 Oh-Hora M, et al., Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders. J Immunol. 2019 May 1;202(9):2616-2627

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory