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Optc Gene Detail
Summary
  • Symbol
    Optc
  • Name
    opticin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151113
    NCBI Gene: 269120
  • Gene Overview
    MyGene.info: OPTC
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:133897199-133907999 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10801 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.02 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    OPTC, opticin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OPTC, opticin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OPT
  • Links
    NCBI Gene ID: 26254
    neXtProt AC: NX_Q9UBM4
    UniProt: Q9UBM4

  • Chr Location
    1q32.1; chr1:203494143-203508949 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased preretinal neovascularization in an oxygen-induced retinopathy model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026873 VEGA Gene Model | MGI Sequence Detail 10801 C57BL/6J ±  kb
    transcript OTTMUST00000066466 VEGA | MGI Sequence Detail 1885 Not Applicable  
    polypeptide OTTMUSP00000033310 VEGA | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      155 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 3
      cDNA 9
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:191528 Le Goff MM, et al., The vitreous glycoprotein opticin inhibits preretinal neovascularization. Invest Ophthalmol Vis Sci. 2012 Jan;53(1):228-34

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory