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Fgfrl1 Gene Detail
Summary
  • Symbol
    Fgfrl1
  • Name
    fibroblast growth factor receptor-like 1
  • Synonyms
    FGFR5, FGFR5beta, FGFR5gamma, fibroblast growth factor receptor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150920
    NCBI Gene: 116701
  • Gene Overview
    MyGene.info: FGFRL1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:108694229-108706950 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.24 cM, cytoband E3-F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150920
protein coding gene Chr5:108692382-108706950 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029864
protein coding gene Chr5:110826878-110841415 (+)
A/J MGP_AJ_G0029828
protein coding gene Chr5:106561910-106576482 (+)
AKR/J MGP_AKRJ_G0029773
protein coding gene Chr5:109999276-110014026 (+)
BALB/cJ MGP_BALBcJ_G0029840
protein coding gene Chr5:107702264-107717090 (+)
C3H/HeJ MGP_C3HHeJ_G0029562
protein coding gene Chr5:110493441-110508993 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030294
protein coding gene Chr5:115353749-115371567 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027528
protein coding gene Chr5:101573589-101588063 (+)
CAST/EiJ MGP_CASTEiJ_G0028976
protein coding gene Chr5:109384111-109401483 (+)
CBA/J MGP_CBAJ_G0029530
protein coding gene Chr5:119244088-119263462 (+)
DBA/2J MGP_DBA2J_G0029676
protein coding gene Chr5:106687965-106702715 (+)
FVB/NJ MGP_FVBNJ_G0029633
protein coding gene Chr5:105417628-105432109 (+)
LP/J MGP_LPJ_G0029764
protein coding gene Chr5:111413618-111432692 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029665
protein coding gene Chr5:124127460-124146002 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030328
protein coding gene Chr5:109544251-109558789 (+)
PWK/PhJ MGP_PWKPhJ_G0028689
protein coding gene Chr5:105509954-105552354 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028527
protein coding gene Chr5:107079575-107094123 (+)
WSB/EiJ MGP_WSBEiJ_G0029049
protein coding gene Chr5:109878048-109894073 (+)



Homology
more
  • Human Ortholog
    FGFRL1, fibroblast growth factor receptor like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FGFRL1, fibroblast growth factor receptor like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FGFR5, FHFR
  • Links
    NCBI Gene ID: 53834
    neXtProt AC: NX_Q8N441
    UniProt: Q8N441

  • Chr Location
    4p16.3; chr4:1011822-1026898 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Fgfrl1 mouse models; 1 with human FGFRL1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    81 phenotypes from 4 alleles in 5 genetic backgrounds
    3 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show neonatal death due to respiratory distress, a malformed diaphragm, and lack of metanephric kidneys. Homozygotes for a different null allele show both fetal and neonatal death, a similar diaphragm defect, as well as cardiac and skeletal defects, and fetal anemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 116701 NCBI Gene Model | MGI Sequence Detail 12722 C57BL/6J ±  kb
    transcript NM_054071 RefSeq | MGI Sequence Detail 2656 C57BL/6  
    polypeptide Q91V87 UniProt | EBI | MGI Sequence Detail 529 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 51
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:254511 Inoue K, et al., The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development. Cell Rep. 2017 May 2;19(5):949-956

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory