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Fgfrl1
Gene Detail
Symbol

Name
ID
Fgfrl1
fibroblast growth factor receptor-like 1
MGI:2150920
Synonyms
FGFR5, FGFR5beta, FGFR5gamma, fibroblast growth factor receptor 5
Feature Type
protein coding gene
Genetic Map
Chromosome 5
53.24 cM, cytoband E3-F
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:108694229-108706950 bp, + strand
From NCBI annotation of GRCm38

  12722 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGFRL1
Gene Tree: Fgfrl1

Human
homologs
FGFRL1, fibroblast growth factor receptor-like 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 53834
neXtProt AC: NX_Q8N441

Human Synonyms: FGFR5, FHFR

Human Chr (Location): 4p16; chr4:1009979-1026898 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit neonatal lethality associated with irregular breathing, cyanosis, a thin diaphragm and lack of spontaneous movement.
 
Human Diseases Modeled in Mice Using Fgfrl1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Fgfrl1 interacts with 140 markers (Mir1b, Mir15a, Mir92-2, ...)
Expression
Literature Summary: (16 records)
Data Summary: Results (577)    Tissues (116)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 566
Northern blot 9
RT-PCR 2
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FGFRL1 ; Xenbase fgfrl1 ; ZFIN fgfrl1a, fgfrl1b    NEW 
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000008090 (Evidence)
Entrez Gene 116701 (Evidence)
UniGene 35691
DFCI TC1579044, TC1591432
DoTS DT.101370698, DT.101370700, DT.110668809, DT.491383
NIA Mouse Gene Index U005957
Consensus CDS Project CCDS19518.1, CCDS51592.1
International Mouse Phenotyping Consortium Status Fgfrl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 116701 NCBI Gene Model | MGI Sequence Detail 12722 C57BL/6J ±  kb
transcript NM_054071 RefSeq | MGI Sequence Detail 2656 C57BL/6 
polypeptide Q91V87 UniProt | EBI | MGI Sequence Detail 529 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000007506 fibroblast growth factor receptor-like 1
Graphical View of Protein Domain Structure
References
(Earliest) J:70793 Sleeman M, et al., Identification of a new fibroblast growth factor receptor, FGFR5. Gene. 2001 Jun 27;271(2):171-82
(Latest) J:218981 Bluteau G, et al., Targeted disruption of the intracellular domain of receptor FgfrL1 in mice. PLoS One. 2014;9(8):e105210
All references(42)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory