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Fgfrl1
Gene Detail
 Symbol
Name
ID
Fgfrl1
fibroblast growth factor receptor-like 1
MGI:2150920
Synonyms FGFR5, FGFR5beta, FGFR5gamma, fibroblast growth factor receptor 5
Feature Type protein coding gene
Genetic Map
Chromosome 5
53.24 cM, cytoband E3-F
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:108694229-108706950 bp, + strand
From NCBI annotation of GRCm38

  12722 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fgfrl1

Human
homologs
Human Homolog FGFRL1, fibroblast growth factor receptor-like 1
NCBI Gene ID 53834
neXtProt AC  NX_Q8N441
Human Synonyms  FGFR5, FHFR
Human Chr (Location)  4p16; chr4:1011822-1026898 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit neonatal lethality associated with irregular breathing, cyanosis, a thin diaphragm and lack of spontaneous movement.
 
Human Diseases Modeled Using Mouse Fgfrl1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Fgfrl1 interacts with 140 markers (Mir1b, Mir15a, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell surface receptor signaling pathway, diaphragm development, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function fibroblast growth factor-activated receptor activity, fibroblast growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (577)    Tissues (116)    Images (53)
Theiler Stages: 10, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 566
Northern blot 9
RT-PCR 2
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000008090 (Evidence)
Entrez Gene116701 (Evidence)
UniGene35691
DFCITC1579044, TC1591432
DoTSDT.101370698, DT.101370700, DT.110668809, DT.491383
NIA Mouse Gene IndexU005957
Consensus CDS ProjectCCDS19518.1, CCDS51592.1
International Mouse Knockout Project StatusFgfrl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 116701 NCBI Gene Model | MGI Sequence Detail 12722 C57BL/6J ±  kb
transcript NM_054071 RefSeq | MGI Sequence Detail 2656 C57BL/6 
polypeptide Q91V87 UniProt | EBI | MGI Sequence Detail 529 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000007506 fibroblast growth factor receptor-like 1
Graphical View of Protein Domain Structure
References (Earliest) J:70793 Sleeman M, et al., Identification of a new fibroblast growth factor receptor, FGFR5. Gene. 2001 Jun 27;271(2):171-82
(Latest) J:203801 Amann R, et al., Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1. Int J Mol Med. 2013 Nov;32(5):983-8
All references(41)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory