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Man2a2
Gene Detail
Symbol

Name
ID
Man2a2
mannosidase 2, alpha 2
MGI:2150656
Synonyms
1700052O22Rik, 4931438M07Rik, alpha mannosidase IIx, MX
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.65 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:80349098-80371375 bp, - strand
From Ensembl annotation of GRCm38

  22278 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: lysosomal alpha-mannosidase
Gene Tree: Man2a2

Human
homologs
Human Homolog MAN2A2, mannosidase, alpha, class 2A, member 2
NCBI Gene ID 4122
neXtProt AC  NX_P49641
Human Synonyms  MANA2X
Human Chr (Location)  15q26.1; chr15:90902218-90922585 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null males are infertile due to a defect during spermatogenesis involving the premature release of germ cells from the seminiferous tubules into the epididymis.
 
Interactions
Man2a2 interacts with 258 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process carbohydrate metabolic process, mannose metabolic process, ...
Component Golgi apparatus, integral component of membrane, ...
Function alpha-mannosidase activity, amylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (197)    Tissues (99)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 197
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000038886 (Evidence)
Entrez Gene140481 (Evidence)
DFCITC1584510, TC1601386, TC1607294, TC1656938, TC1646538
DoTSDT.97358067, DT.91336368, DT.87068283, DT.101358709, DT.40177545, DT.91381000
NIA Mouse Gene IndexU028762, U359954
EC3.2.1.-, 3.2.1.114
Consensus CDS ProjectCCDS57556.1
International Mouse Knockout Project StatusMan2a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038886 Ensembl Gene Model | MGI Sequence Detail 22278 C57BL/6J ±  kb
transcript ENSMUST00000098346 Ensembl | MGI Sequence Detail 6553 Not Applicable 
polypeptide ENSMUSP00000095949 Ensembl | MGI Sequence Detail 1152 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(7)
Polymorphisms
SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011013 Galactose mutarotase-like domain
InterPro IPR027291 Glycoside hydrolase 38/57, N-terminal domain
InterPro IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
InterPro IPR015341 Glycoside hydrolase, family 38, central domain
InterPro IPR000602 Glycoside hydrolase family 38, N-terminal domain
InterPro IPR013780 Glycosyl hydrolase, family 13, all-beta
InterPro IPR011682 Glycosyl hydrolase family 38, C-terminal
Protein Ontology PR:000010106 alpha-mannosidase 2x
References
(Earliest) J:44927 Hiramoto S, et al., Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia. Biochem Biophys Res Commun. 1997 Dec 18;241(2):439-45
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)
Other
accession IDs
MGI:1920604, MGI:2141983, MGI:2444118

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory