Man2a2
Gene Detail

Symbol Name ID

Man2a2 mannosidase 2, alpha 2 MGI:2150656

Synonyms

1700052O22Rik, 4931438M07Rik, alpha mannosidase IIx, MX

Feature Type

protein coding gene

Genetic Map

Chromosome 7

45.65 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:80349098-80371375 bp, - strand From Ensembl annotation of GRCm38   22278 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lysosomal alpha-mannosidase
Gene Tree: Man2a2

Human homologs

Human Homolog		MAN2A2, mannosidase, alpha, class 2A, member 2
NCBI Gene ID		4122
neXtProt AC		NX_P49641
Human Synonyms		MANA2X
Human Chr (Location)		15q26.1; chr15:91447420-91465815 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous null males are infertile due to a defect during spermatogenesis involving the premature release of germ cells from the seminiferous tubules into the epididymis.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	carbohydrate metabolic process, mannose metabolic process, ...
Component	Golgi apparatus, integral to membrane, ...
Function	alpha-mannosidase activity, carbohydrate binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (197)    Tissues (98)   
Theiler Stages: 22, 24, 28

Assay Type	Results
RNA in situ	197

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000038886 (Evidence)
Entrez Gene	140481 (Evidence)
DFCI	TC1584510, TC1601386, TC1607294, TC1646538, TC1656938
DoTS	DT.101358709, DT.40177545, DT.87068283, DT.91336368, DT.91381000, DT.97358067
NIA Mouse Gene Index	U028762, U359954
EC	3.2.1.114
Consensus CDS Project	CCDS57556.1
International Mouse Knockout Project Status	Man2a2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000038886	Ensembl Gene Model | MGI Sequence Detail	22278	C57BL/6J
transcript	ENSMUST00000098346	Ensembl | MGI Sequence Detail	6553	Not Applicable
polypeptide	ENSMUSP00000095949	Ensembl | MGI Sequence Detail	1152	Not Applicable

All sequences(39) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(58 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011330	Glycoside hydrolase/deacetylase, beta/alpha-barrel
InterPro	IPR015341	Glycoside hydrolase, family 38, central domain
InterPro	IPR000602	Glycoside hydrolase, family 38, core
InterPro	IPR011013	Glycoside hydrolase-type carbohydrate-binding
InterPro	IPR013780	Glycosyl hydrolase, family 13, all-beta
InterPro	IPR011682	Glycosyl hydrolase family 38, C-terminal
Protein Ontology	PR:000010106	alpha-mannosidase 2x

References

(Earliest) J:44927 Hiramoto S, et al., Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia. Biochem Biophys Res Commun. 1997 Dec 18;241(2):439-45
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)

Other accession IDs

MGI:1920604, MGI:2141983, MGI:2444118