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Man2a2 Gene Detail
Summary
  • Symbol
    Man2a2
  • Name
    mannosidase 2, alpha 2
  • Synonyms
    1700052O22Rik, 4931438M07Rik, alpha mannosidase IIx, MX
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150656
    NCBI Gene: 140481
Location & Maps
more
  • Sequence Map
    Chr7:80349097-80371375 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22279 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MAN2A2, mannosidase alpha class 2A member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAN2A2, mannosidase alpha class 2A member 2
    Orthology source: HomoloGene
  • Synonyms
    MANA2X
  • Links
    NCBI Gene ID: 4122
    neXtProt AC: NX_P49641

  • Chr Location
    15q26.1; chr15:90902218-90922585 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Man2a2
  • Incidental Mutations
Homozygous null males are infertile due to a defect during spermatogenesis involving the premature release of germ cells from the seminiferous tubules into the epididymis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058665 VEGA Gene Model | MGI Sequence Detail 22279 C57BL/6J ±  kb
transcript OTTMUST00000144083 VEGA | MGI Sequence Detail 6554 Not Applicable  
polypeptide OTTMUSP00000075122 VEGA | MGI Sequence Detail 1152 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    190 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000010106 alpha-mannosidase 2x
  • EC
  • InterPro Domains
    IPR011013 Galactose mutarotase-like domain
    IPR027291 Glycoside hydrolase 38/57, N-terminal domain
    IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
    IPR028995 Glycoside hydrolase families 57/38, central domain
    IPR015341 Glycoside hydrolase family 38, central domain
    IPR000602 Glycoside hydrolase family 38, N-terminal domain
    IPR013780 Glycosyl hydrolase, all-beta
    IPR011682 Glycosyl hydrolase family 38, C-terminal
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1920604, MGI:2141983, MGI:2444118
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:44927 Hiramoto S, et al., Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia. Biochem Biophys Res Commun. 1997 Dec 18;241(2):439-45
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory