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S1pr5
Gene Detail
Symbol

Name
ID
S1pr5
sphingosine-1-phosphate receptor 5
MGI:2150641
Synonyms
Edg8, lpB4, S1P5
Feature Type
protein coding gene
Genetic Map
Chromosome 9
7.75 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:21242912-21248443 bp, - strand
From VEGA annotation of GRCm38

  5532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11031  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: S1PR5
Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr5

Human
homologs
S1PR5, sphingosine-1-phosphate receptor 5
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 53637
neXtProt AC: NX_Q9H228

Human Synonyms: Edg-8, EDG8, S1P5, SPPR-1, SPPR-2

Human Chr (Location): 19p13.2; chr19:10512742-10517992 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Bone marrow from mice homozygous for a knock-out allele induces impaired NK cell egression from the lymph nodes and bone marrow.
 
Interactions
S1pr5 interacts with 126 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (97)    Tissues (70)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 84
RT-PCR 13
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase s1pr5 ; ZFIN s1pr5a    NEW 
Molecular
reagents
All nucleic(11) cDNA(8) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000028855 (Evidence)
Ensembl Gene Model ENSMUSG00000045087 (Evidence)
Entrez Gene 94226 (Evidence)
UniGene 190619
DFCI TC1585945
DoTS DT.60100714
NIA Mouse Gene Index U030574
Consensus CDS Project CCDS22898.1
International Mouse Phenotyping Consortium Status S1pr5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028855 VEGA Gene Model | MGI Sequence Detail 5532 C57BL/6J ±  kb
transcript OTTMUST00000071461 VEGA | MGI Sequence Detail 2500 Not Applicable 
polypeptide OTTMUSP00000036619 VEGA | MGI Sequence Detail 400 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005386 EDG-8 sphingosine 1-phosphate receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004061 Sphingosine 1-phosphate receptor
Protein Ontology PR:000001710 sphingosine 1-phosphate receptor 5
References
(Earliest) J:71372 Ishii I, et al., Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem. 2001 Sep 7;276(36):33697-704
(Latest) J:216561 Adada M, et al., Sphingosine-1-phosphate receptor 2. FEBS J. 2013 Dec;280(24):6354-66
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory