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S1pr5
Gene Detail
 Symbol
Name
ID
S1pr5
sphingosine-1-phosphate receptor 5
MGI:2150641
Synonyms Edg8, lpB4, S1P5
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.75 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:21242912-21248443 bp, - strand
From VEGA annotation of GRCm38

  5532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11031  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr5

Human
homologs
Human Homolog S1PR5, sphingosine-1-phosphate receptor 5
NCBI Gene ID 53637
neXtProt AC  NX_Q9H228
Human Synonyms  Edg-8, EDG8, S1P5, SPPR-1, SPPR-2
Human Chr (Location)  19p13.2; chr19:10512742-10517992 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Bone marrow from mice homozygous for a knock-out allele induces impaired NK cell egression from the lymph nodes and bone marrow.
 
Interactions
S1pr5 interacts with 126 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process G-protein coupled receptor signaling pathway, signal transduction
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (97)    Tissues (70)    Images (30)
Theiler Stages: 11, 12, 13, 15, 17, 19, 20, 23, 28
Assay TypeResults
RNA in situ 84
RT-PCR 13
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(8) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028855 (Evidence)
Ensembl Gene ModelENSMUSG00000045087 (Evidence)
Entrez Gene94226 (Evidence)
UniGene190619
DFCITC1585945
DoTSDT.60100714
NIA Mouse Gene IndexU030574
Consensus CDS ProjectCCDS22898.1
International Mouse Knockout Project StatusS1pr5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028855 VEGA Gene Model | MGI Sequence Detail 5532 C57BL/6J ±  kb
transcript OTTMUST00000071461 VEGA | MGI Sequence Detail 2500 Not Applicable 
polypeptide OTTMUSP00000036619 VEGA | MGI Sequence Detail 400 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005386 EDG-8 sphingosine 1-phosphate receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004061 Sphingosine 1-phosphate receptor
Protein Ontology PR:000001710 sphingosine 1-phosphate receptor 5
References (Earliest) J:71372 Ishii I, et al., Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem. 2001 Sep 7;276(36):33697-704
(Latest) J:198231 Debien E, et al., S1PR5 is pivotal for the homeostasis of patrolling monocytes. Eur J Immunol. 2013 Jun;43(6):1667-75
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory