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Dcun1d1 Gene Detail
Summary
  • Symbol
    Dcun1d1
  • Name
    DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
  • Synonyms
    pTes3, Rp42, SCCRO, Tes3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150386
    NCBI Gene: 114893
  • Gene Overview
    MyGene.info: DCUN1D1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:35892105-35937440 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 17.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150386
protein coding gene Chr3:35892105-35937445 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027152
protein coding gene Chr3:33641565-33691354 (-)
A/J MGP_AJ_G0027112
protein coding gene Chr3:33024443-33065538 (-)
AKR/J MGP_AKRJ_G0027081
protein coding gene Chr3:33619695-33664082 (-)
BALB/cJ MGP_BALBcJ_G0027124
protein coding gene Chr3:32779726-32821633 (-)
C3H/HeJ MGP_C3HHeJ_G0026867
protein coding gene Chr3:33697179-33738678 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027570
protein coding gene Chr3:35282569-35329810 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024931
protein coding gene Chr3:30749163-30792867 (-)
CAST/EiJ MGP_CASTEiJ_G0026320
protein coding gene Chr3:33529201-33574541 (-)
CBA/J MGP_CBAJ_G0026844
protein coding gene Chr3:36220175-36265528 (-)
DBA/2J MGP_DBA2J_G0026978
protein coding gene Chr3:32497891-32539856 (-)
FVB/NJ MGP_FVBNJ_G0026946
protein coding gene Chr3:31938303-31981169 (-)
LP/J MGP_LPJ_G0027090
protein coding gene Chr3:34423614-34468765 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026966
protein coding gene Chr3:38677123-38725321 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027629
protein coding gene Chr3:33469135-33511506 (-)
PWK/PhJ MGP_PWKPhJ_G0026053
protein coding gene Chr3:32143343-32187093 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025865
protein coding gene Chr3:32848244-32888642 (-)
WSB/EiJ MGP_WSBEiJ_G0026394
protein coding gene Chr3:33497615-33540598 (-)



Homology
more
  • Human Ortholog
    DCUN1D1, defective in cullin neddylation 1 domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DCUN1D1, defective in cullin neddylation 1 domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3
  • Links
    NCBI Gene ID: 54165
    neXtProt AC: NX_Q96GG9
    UniProt: Q96GG9

  • Chr Location
    3q26.33; chr3:182938158-182986364 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mcie homozygous for a knock-out allele are runted with spleen and lymphoid hypoplasia and decreased mouse embryonic fibroblast proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114893 NCBI Gene Model | MGI Sequence Detail 45336 C57BL/6J ±  kb
    transcript NM_001205361 RefSeq | MGI Sequence Detail 4474 C57BL/6  
    polypeptide NP_001192290 RefSeq | MGI Sequence Detail 259 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1858962, MGI:2140091
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 2
      Phenotypes 4
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:245971 Huang G, et al., Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission. J Biol Chem. 2017 Sep 15;292(37):15254-15265

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory