Srd5a2
Gene Detail

Symbol Name ID

Srd5a2 steroid 5 alpha-reductase 2 MGI:2150380

Synonyms

5ART2

Feature Type

protein coding gene

Genetic Map

Chromosome 17

45.39 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:74017706-74047916 bp, - strand From NCBI annotation of GRCm38   30211 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37292  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: 3-oxo-5-alpha-steroid 4-dehydrogenase 2
Gene Tree: Srd5a2

Human homologs

Human Homolog		SRD5A2, steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
NCBI Gene ID		6716
neXtProt AC		NX_P31213
Human Chr (Location)		2p23; chr2:31749656-31806040 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SRD5A2

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous null mutant males are fertile, but have small prostates and seminal vesicles, elevated testosterone in reproductive tissue and decreased androgen-dependent gene expression. Mutant females exhibit no detectable abnormality.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	androgen biosynthetic process, androgen metabolic process, ...
Component	cell body fiber, cytoplasm, ...
Function	3-oxo-5-alpha-steroid 4-dehydrogenase activity, amide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000038541 (Evidence)
Entrez Gene	94224 (Evidence)
UniGene	38933
DFCI	TC1609529
DoTS	DT.91297097
NIA Mouse Gene Index	U038048
EC	1.3.1.22
Consensus CDS Project	CCDS28968.1
International Mouse Knockout Project Status	Srd5a2

Sequences

Length	Strain/Species
genomic	94224	NCBI Gene Model | MGI Sequence Detail	30211	C57BL/6J
transcript	NM_053188	RefSeq | MGI Sequence Detail	854	C57BL/6
polypeptide	Q99N99	UniProt | EBI | MGI Sequence Detail	254	Not Applicable

All sequences(13) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(151 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016636	3-oxo-5-alpha-steroid 4-dehydrogenase
InterPro	IPR001104	3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
Protein Ontology	PR:000015608	3-oxo-5-alpha-steroid 4-dehydrogenase 2

Graphical View of Protein Domain Structure

References

(Earliest) J:72807 Mahendroo MS, et al., Unexpected virilization in male mice lacking steroid 5alpha-reductase enzymes. Endocrinology. 2001 Nov;142(11):4652-62
(Latest) J:192391 Kerkhofs S, et al., A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5alpha reductase II gene. FASEB J. 2012 Oct;26(10):4360-72
All references(31)