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Srd5a2
Gene Detail
Symbol

Name
ID
Srd5a2
steroid 5 alpha-reductase 2
MGI:2150380
Synonyms
5ART2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
45.39 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:74017706-74047916 bp, - strand
From NCBI annotation of GRCm38

  30211 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37292  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: 3-oxo-5-alpha-steroid 4-dehydrogenase 2
Gene Tree: Srd5a2

Human
homologs
Human Homolog SRD5A2, steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
NCBI Gene ID 6716
neXtProt AC  NX_P31213
Human Chr (Location)  2p23; chr2:31524586-31580971 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SRD5A2
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutant males are fertile, but have small prostates and seminal vesicles, elevated testosterone in reproductive tissue and decreased androgen-dependent gene expression. Mutant females exhibit no detectable abnormality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process androgen biosynthetic process, androgen metabolic process, ...
Component cell body fiber, cytoplasm, ...
Function 3-oxo-5-alpha-steroid 4-dehydrogenase activity, amide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (353)    Tissues (308)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 353
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000038541 (Evidence)
Entrez Gene94224 (Evidence)
UniGene38933
DFCITC1609529
DoTSDT.91297097
NIA Mouse Gene IndexU038048
EC1.3.1.22
Consensus CDS ProjectCCDS28968.1
International Mouse Knockout Project StatusSrd5a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 94224 NCBI Gene Model | MGI Sequence Detail 30211 C57BL/6J ±  kb
transcript NM_053188 RefSeq | MGI Sequence Detail 854 C57BL/6 
polypeptide Q99N99 UniProt | EBI | MGI Sequence Detail 254 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(208 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016636 3-oxo-5-alpha-steroid 4-dehydrogenase
InterPro IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
Protein Ontology PR:000015608 3-oxo-5-alpha-steroid 4-dehydrogenase 2
Graphical View of Protein Domain Structure
References
(Earliest) J:72807 Mahendroo MS, et al., Unexpected virilization in male mice lacking steroid 5alpha-reductase enzymes. Endocrinology. 2001 Nov;142(11):4652-62
(Latest) J:204055 Dowman JK, et al., Loss of 5alpha-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice. Endocrinology. 2013 Dec;154(12):4536-47
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory