Slc4a10
Gene Detail

Symbol Name ID

Slc4a10 solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 MGI:2150150

Synonyms

NCBE

Feature Type

protein coding gene

Genetic Map

Chromosome 2

35.79 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:62046462-62326730 bp, + strand From VEGA annotation of GRCm38   280269 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23340  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a10

Human homologs

Human Homolog		SLC4A10, solute carrier family 4, sodium bicarbonate transporter, member 10
NCBI Gene ID		57282
neXtProt AC		NX_Q6U841
Human Synonyms		NBCn2, NCBE
Human Chr (Location)		2q24.2; chr2:161624189-161985276 (+)  GRCh38

Alleles and phenotypes

All alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice with homozygous disruption of this gene exhibit reduced brain ventricle volume, reduced neuronal excitability, impaired pH regulation of neurons, and increased threshold to induced seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	anion transport, ion transmembrane transport, ...
Component	basolateral plasma membrane, integral component of membrane, ...
Function	anion:anion antiporter activity, anion transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (259)    Tissues (184)    Images (56)
Theiler Stages: 5, 10, 18, 20, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	255
Northern blot	4

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000012738 (Evidence)
Ensembl Gene Model	ENSMUSG00000026904 (Evidence)
Entrez Gene	94229 (Evidence)
UniGene	314497
DFCI	TC1580391
DoTS	DT.101310799, DT.110708013, DT.485009
NIA Mouse Gene Index	U001816
Consensus CDS Project	CCDS16064.1, CCDS57172.1, CCDS57173.1
International Mouse Knockout Project Status	Slc4a10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012738	VEGA Gene Model | MGI Sequence Detail	280269	C57BL/6J
transcript	OTTMUST00000030427	VEGA | MGI Sequence Detail	5389	Not Applicable
polypeptide	OTTMUSP00000013681	VEGA | MGI Sequence Detail	1118	Not Applicable

All sequences(85) RefSeq(22) UniProt(13)

Polymorphisms

SNPs within 2kb(1114 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1118)

Protein-related information

Resource	ID	Description
InterPro	IPR013769	Band 3 cytoplasmic domain
InterPro	IPR011531	Bicarbonate transporter, C-terminal
InterPro	IPR003020	Bicarbonate transporter, eukaryotic
InterPro	IPR016152	Phosphotransferase/anion transporter
InterPro	IPR003024	Sodium bicarbonate cotransporter
Protein Ontology	PR:000015155	sodium-driven chloride bicarbonate exchanger

References

(Earliest) J:70983 Wang CZ, et al., The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. J Biol Chem. 2000 Nov 10;275(45):35486-90
(Latest) J:201360 Coley AA, et al., Immunocytochemical identification of electroneutral Na(+)-coupled HCO(3)(-) transporters in freshly dissociated mouse medullary raphe neurons. Neuroscience. 2013 Aug 29;246:451-67
All references(42)