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Slc4a10
Gene Detail
Symbol

Name
ID
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
MGI:2150150
Synonyms
NCBE
Feature Type
protein coding gene
Genetic Map
Chromosome 2
35.79 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:62046462-62326730 bp, + strand
From VEGA annotation of GRCm38

  280269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23340  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SLC4A10
Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a10

Human
homologs
SLC4A10, solute carrier family 4, sodium bicarbonate transporter, member 10
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57282
neXtProt AC: NX_Q6U841

Human Synonyms: NBCn2, NCBE

Human Chr (Location): 2q24.2; chr2:161624335-161985276 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice with homozygous disruption of this gene exhibit reduced brain ventricle volume, reduced neuronal excitability, impaired pH regulation of neurons, and increased threshold to induced seizures.
 
Interactions
Slc4a10 interacts with 359 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process anion transmembrane transport, anion transport, ...
Component apical dendrite, basilar dendrite, ...
Function anion:anion antiporter activity, anion transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (259)    Tissues (184)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 255
Northern blot 4
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc4a10 ; ZFIN slc4a10a    NEW 
Molecular
reagents
All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000012738 (Evidence)
Ensembl Gene Model ENSMUSG00000026904 (Evidence)
Entrez Gene 94229 (Evidence)
UniGene 314497
DFCI TC1580391
DoTS DT.101310799, DT.485009, DT.110708013
NIA Mouse Gene Index U001816
Consensus CDS Project CCDS16064.1, CCDS57172.1, CCDS57173.1
International Mouse Phenotyping Consortium Status Slc4a10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012738 VEGA Gene Model | MGI Sequence Detail 280269 C57BL/6J ±  kb
transcript OTTMUST00000030427 VEGA | MGI Sequence Detail 5389 Not Applicable 
polypeptide OTTMUSP00000013681 VEGA | MGI Sequence Detail 1118 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(24) UniProt(13)
Polymorphisms
SNPs within 2kb(1114 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1118)
Protein-related
information
ResourceIDDescription
InterPro IPR013769 Band 3 cytoplasmic domain
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
InterPro IPR003024 Sodium bicarbonate cotransporter
Protein Ontology PR:000015155 sodium-driven chloride bicarbonate exchanger
References
(Earliest) J:70983 Wang CZ, et al., The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. J Biol Chem. 2000 Nov 10;275(45):35486-90
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory