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Slc4a10
Gene Detail
 Symbol
Name
ID
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
MGI:2150150
Synonyms NCBE
Feature Type protein coding gene
Genetic Map
Chromosome 2
35.79 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:62046462-62326730 bp, + strand
From VEGA annotation of GRCm38

  280269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23340  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: band 3-like protein
Gene Tree: Slc4a10

Human
homologs
Human Homolog SLC4A10, solute carrier family 4, sodium bicarbonate transporter, member 10
NCBI Gene ID 57282
neXtProt AC  NX_Q6U841
Human Synonyms  NBCn2, NCBE
Human Chr (Location)  2q24.2; chr2:161624189-161985276 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice with homozygous disruption of this gene exhibit reduced brain ventricle volume, reduced neuronal excitability, impaired pH regulation of neurons, and increased threshold to induced seizures.
 
Interactions
Slc4a10 interacts with 359 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process anion transport, ion transmembrane transport, ...
Component basolateral plasma membrane, integral component of membrane, ...
Function anion:anion antiporter activity, anion transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (259)    Tissues (184)    Images (56)
Theiler Stages: 5, 10, 18, 20, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 255
Northern blot 4
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012738 (Evidence)
Ensembl Gene ModelENSMUSG00000026904 (Evidence)
Entrez Gene94229 (Evidence)
UniGene314497
DFCITC1580391
DoTSDT.101310799, DT.110708013, DT.485009
NIA Mouse Gene IndexU001816
Consensus CDS ProjectCCDS16064.1, CCDS57172.1, CCDS57173.1
International Mouse Knockout Project StatusSlc4a10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012738 VEGA Gene Model | MGI Sequence Detail 280269 C57BL/6J ±  kb
transcript OTTMUST00000030427 VEGA | MGI Sequence Detail 5389 Not Applicable 
polypeptide OTTMUSP00000013681 VEGA | MGI Sequence Detail 1118 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(22) UniProt(13)
Polymorphisms SNPs within 2kb(1114 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1118)
Protein-related
information
ResourceIDDescription
InterPro IPR013769 Band 3 cytoplasmic domain
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
InterPro IPR003024 Sodium bicarbonate cotransporter
Protein Ontology PR:000015155 sodium-driven chloride bicarbonate exchanger
References (Earliest) J:70983 Wang CZ, et al., The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. J Biol Chem. 2000 Nov 10;275(45):35486-90
(Latest) J:201360 Coley AA, et al., Immunocytochemical identification of electroneutral Na(+)-coupled HCO(3)(-) transporters in freshly dissociated mouse medullary raphe neurons. Neuroscience. 2013 Aug 29;246:451-67
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory