Slc4a10 MGI Mouse Gene Detail - MGI:2150150 - solute carrier family 4, sodium bicarbonate cotransporter-like, member 10

Slc4a10 Gene Detail

Symbol

Slc4a10
Name

solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms

NCBE

Feature Type

protein coding gene
IDs

MGI:2150150
NCBI Gene: 94229

Sequence Map

Chr2:62046462-62326730 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

280269 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 35.79 cM, cytoband C3
Mapping Data

3 experiments

Human Ortholog

SLC4A10, solute carrier family 4 member 10

Vertebrate Orthologs

11

Human Ortholog

SLC4A10, solute carrier family 4 member 10
Orthology source: HomoloGene, HGNC
Synonyms

NBCn2, NCBE
Links

HGNC:13811

NCBI Gene ID: 57282

neXtProt AC: NX_Q6U841

UniProt: Q6U841
Chr Location

2q24.2; chr2:161624335-161985276 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 23340
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SLC4A10
Protein SuperFamily

band 3-like protein
Gene Tree

Slc4a10

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Slc4a10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

49 strains or lines available

Mice with homozygous disruption of this gene exhibit reduced brain ventricle volume, reduced neuronal excitability, impaired pH regulation of neurons, and increased threshold to induced seizures.

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All GO Annotations

35
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

259
Tissues

184
cDNA Data

31
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc4a10

ZFIN slc4a10a

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Slc4a10 interacts with 359 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

84
RefSeq

26
UniProt

13
CCDS

CCDS16064.1, CCDS57172.1, CCDS57173.1
UniGene

314497

			Length	Strain/Species	Flank
genomic	OTTMUSG00000012738	VEGA Gene Model \| MGI Sequence Detail	280269	C57BL/6J	± kb
transcript	OTTMUST00000030427	VEGA \| MGI Sequence Detail	5389	Not Applicable
polypeptide	OTTMUSP00000013681	VEGA \| MGI Sequence Detail	1118	Not Applicable

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SNPs within 2kb

1099 from dbSNP Build 142

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UniProt

13 Sequences
Protein Ontology

PR:000015155 sodium-driven chloride bicarbonate exchanger

(term hierarchy)
InterPro Domains

IPR013769 Band 3 cytoplasmic domain

IPR011531 Bicarbonate transporter, C-terminal

IPR003020 Bicarbonate transporter, eukaryotic

IPR016152 Phosphotransferase/anion transporter

IPR003024 Sodium bicarbonate cotransporter

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All nucleic 33

cDNA 32

Primer pair 1

Microarray probesets 4

Summaries

All 45

Developmental Gene Expression 8

Gene Ontology 8

Phenotypes 14
Earliest

J:70983 Wang CZ, et al., The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. J Biol Chem. 2000 Nov 10;275(45):35486-90
Latest

J:234901 Potter PK, et al., Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Nat Commun. 2016;7:12444

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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