About   Help   FAQ
Slc4a10 Gene Detail
Summary
  • Symbol
    Slc4a10
  • Name
    solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
  • Synonyms
    NCBE
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150150
    NCBI Gene: 94229
Location & Maps
more
  • Sequence Map
    Chr2:62046462-62326730 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      280269 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC4A10, solute carrier family 4 member 10
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC4A10, solute carrier family 4 member 10
    Orthology source: HomoloGene
  • Synonyms
    NBCn2, NCBE
  • Links
    NCBI Gene ID: 57282
    neXtProt AC: NX_Q6U841

  • Chr Location
    2q24.2; chr2:161624335-161985276 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Slc4a10
  • Incidental Mutations
Mice with homozygous disruption of this gene exhibit reduced brain ventricle volume, reduced neuronal excitability, impaired pH regulation of neurons, and increased threshold to induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012738 VEGA Gene Model | MGI Sequence Detail 280269 C57BL/6J ±  kb
transcript OTTMUST00000030427 VEGA | MGI Sequence Detail 5389 Not Applicable  
polypeptide OTTMUSP00000013681 VEGA | MGI Sequence Detail 1118 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1099 from dbSNP Build 142
Protein
Information
less
  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000015155 sodium-driven chloride bicarbonate exchanger
  • InterPro Domains
    IPR013769 Band 3 cytoplasmic domain
    IPR011531 Bicarbonate transporter, C-terminal
    IPR003020 Bicarbonate transporter, eukaryotic
    IPR016152 Phosphotransferase/anion transporter
    IPR003024 Sodium bicarbonate cotransporter
Molecular
Reagents
less
  • All nucleic 33
    cDNA 32
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:70983 Wang CZ, et al., The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. J Biol Chem. 2000 Nov 10;275(45):35486-90
  • Latest
    J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory