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Rad51c Gene Detail
Summary
  • Symbol
    Rad51c
  • Name
    RAD51 paralog C
  • Synonyms
    Rad51l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150020
    NCBI Gene: 114714
  • Gene Overview
    MyGene.info: RAD51C
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:87377607-87404954 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 52.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150020
protein coding gene Chr11:87376645-87404954 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018903
protein coding gene Chr11:88971230-89009452 (-)
A/J MGP_AJ_G0018870
protein coding gene Chr11:85549597-85578067 (-)
AKR/J MGP_AKRJ_G0018840
protein coding gene Chr11:88109877-88143074 (-)
BALB/cJ MGP_BALBcJ_G0018843
protein coding gene Chr11:85949202-85979631 (-)
C3H/HeJ MGP_C3HHeJ_G0018657
protein coding gene Chr11:88129740-88159851 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019295
protein coding gene Chr11:91653512-91690291 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016928
protein coding gene Chr11:82579287-82609292 (-)
CAST/EiJ MGP_CASTEiJ_G0018212
protein coding gene Chr11:88838308-88868182 (-)
CBA/J MGP_CBAJ_G0018628
protein coding gene Chr11:95513208-95550031 (-)
DBA/2J MGP_DBA2J_G0018736
protein coding gene Chr11:85109350-85138083 (-)
FVB/NJ MGP_FVBNJ_G0018725
protein coding gene Chr11:84615063-84643581 (-)
LP/J MGP_LPJ_G0018806
protein coding gene Chr11:89471957-89501870 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018752
protein coding gene Chr11:95570910-95604681 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019335
protein coding gene Chr11:88343563-88373414 (-)
PWK/PhJ MGP_PWKPhJ_G0017982
protein coding gene Chr11:85930926-85959563 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017774
protein coding gene Chr11:87913449-87948324 (-)
WSB/EiJ MGP_WSBEiJ_G0018263
protein coding gene Chr11:88225377-88265527 (-)



Homology
more
  • Human Ortholog
    RAD51C, RAD51 paralog C
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RAD51C, RAD51 paralog C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BROVCA3, FANCO, R51H3, RAD51L2
  • Links
    NCBI Gene ID: 5889
    neXtProt AC: NX_O43502
    UniProt: O43502

  • Chr Location
    17q22; chr17:58692538-58734342 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human RAD51C associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 4 alleles in 4 genetic backgrounds
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality. Mice carrying a null and a hypomorphic allele have partial penetrance of male and female infertility due to defects in meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114714 NCBI Gene Model | MGI Sequence Detail 27348 C57BL/6J ±  kb
    transcript NM_001291440 RefSeq | MGI Sequence Detail 4084 C57BL/6  
    polypeptide Q924H5 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013675 DNA repair protein RAD51 homolog 3
    • InterPro Domains
      IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
      IPR016467 DNA recombination and repair protein, RecA-like
      IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
      IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR033925 Rad51/DMC1/RadA
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 15

      Microarray probesets 4
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:230651 Tumiati M, et al., Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers. Oncogene. 2016 Sep 1;35(35):4601-10

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory