Rad51c
Gene Detail

Symbol Name ID

Rad51c RAD51 homolog C MGI:2150020

Synonyms

Rad51l2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

52.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:87376645-87404954 bp, - strand From VEGA annotation of GRCm38   28310 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14238  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA repair and recombination protein, Rad51 type
Gene Tree: Rad51c

Human homologs

Human Homolog		RAD51C, RAD51 homolog C (S. cerevisiae)
NCBI Gene ID		5889
neXtProt AC		NX_O43502
Human Synonyms		BROVCA3, FANCO, RAD51L2
Human Chr (Location)		17q25.1; chr17:56769963-56811692 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human RAD51C

Alleles and phenotypes

All alleles(23) : Targeted(6) Gene trapped(17)
 

Mice homozygous for a null mutation display embryonic lethality. Mice carrying a null and a hypomorphic allele have partial penetrance of male and female infertility due to defects in meiosis.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	DNA metabolic process, DNA recombination, ...
Component	cytoplasm, Holliday junction resolvase complex, ...
Function	ATP binding, crossover junction endodeoxyribonuclease activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Northern blot	12

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(2) cDNA(15)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000001261 (Evidence)
Ensembl Gene Model	ENSMUSG00000007646 (Evidence)
Entrez Gene	114714 (Evidence)
UniGene	37376
DFCI	TC1586625, TC1599326
DoTS	DT.101363223, DT.110538635, DT.40137340, DT.91300130
NIA Mouse Gene Index	U033240
Consensus CDS Project	CCDS25212.1
International Mouse Knockout Project Status	Rad51c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001261	VEGA Gene Model | MGI Sequence Detail	28310	C57BL/6J
transcript	OTTMUST00000002513	VEGA | MGI Sequence Detail	1632	Not Applicable
polypeptide	OTTMUSP00000001238	VEGA | MGI Sequence Detail	384	Not Applicable

All sequences(48) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014774	Circadian clock protein KaiC/DNA repair protein RadA
InterPro	IPR013632	DNA recombination and repair protein Rad51, C-terminal
InterPro	IPR016467	DNA recombination and repair protein, RecA-like
InterPro	IPR020588	DNA recombination/repair protein RecA/RadB, ATP-binding domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000013675	DNA repair protein RAD51 3

References

(Earliest) J:70804 Leasure CS, et al., Sequence, chromosomal location and expression analysis of the murine homologue of human RAD51L2/RAD51C. Gene. 2001 Jun 13;271(1):59-67
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)