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Rad51c
Gene Detail
Symbol

Name
ID
Rad51c
RAD51 homolog C
MGI:2150020
Synonyms
Rad51l2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
52.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:87376645-87404954 bp, - strand
From VEGA annotation of GRCm38

  28310 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14238  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA repair and recombination protein, Rad51 type
Gene Tree: Rad51c

Human
homologs
Human Homolog RAD51C, RAD51 paralog C
NCBI Gene ID 5889
neXtProt AC  NX_O43502
Human Synonyms  BROVCA3, FANCO, R51H3, RAD51L2
Human Chr (Location)  17q22; chr17:58692573-58734342 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human RAD51C
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(17) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality. Mice carrying a null and a hypomorphic allele have partial penetrance of male and female infertility due to defects in meiosis.
 
Phenotype Images(2)
Interactions
Rad51c interacts with 338 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001261 (Evidence)
Ensembl Gene ModelENSMUSG00000007646 (Evidence)
Entrez Gene114714 (Evidence)
UniGene37376
DFCITC1586625, TC1599326
DoTSDT.91300130, DT.40137340, DT.110538635, DT.101363223
NIA Mouse Gene IndexU033240
Consensus CDS ProjectCCDS25212.1
International Mouse Knockout Project StatusRad51c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001261 VEGA Gene Model | MGI Sequence Detail 28310 C57BL/6J ±  kb
transcript OTTMUST00000002513 VEGA | MGI Sequence Detail 1632 Not Applicable 
polypeptide OTTMUSP00000001238 VEGA | MGI Sequence Detail 384 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013632 DNA recombination and repair protein Rad51, C-terminal
InterPro IPR016467 DNA recombination and repair protein, RecA-like
InterPro IPR020588 DNA recombination/repair protein RecA/RadB, ATP-binding domain
InterPro IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000013675 DNA repair protein RAD51 homolog 3
References
(Earliest) J:70804 Leasure CS, et al., Sequence, chromosomal location and expression analysis of the murine homologue of human RAD51L2/RAD51C. Gene. 2001 Jun 13;271(1):59-67
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory