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Rad51c
Gene Detail
Symbol

Name
ID
Rad51c
RAD51 homolog C
MGI:2150020
Synonyms
Rad51l2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
52.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:87376645-87404954 bp, - strand
From VEGA annotation of GRCm38

  28310 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14238  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAD51C
Protein SuperFamily: DNA repair and recombination protein, Rad51 type
Gene Tree: Rad51c

Human
homologs
RAD51C, RAD51 paralog C
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5889
neXtProt AC: NX_O43502

Human Synonyms: BROVCA3, FANCO, R51H3, RAD51L2

Human Chr (Location): 17q22; chr17:58692536-58734342 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human RAD51C

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(17) Targeted(7)
Genomic Mutations involving Rad51c (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality. Mice carrying a null and a hypomorphic allele have partial penetrance of male and female infertility due to defects in meiosis.
 
Phenotype Images(2)
Interactions
Rad51c interacts with 338 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rad51c ; ZFIN rad51c    NEW 
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000001261 (Evidence)
Ensembl Gene Model ENSMUSG00000007646 (Evidence)
Entrez Gene 114714 (Evidence)
UniGene 37376
DFCI TC1599326, TC1586625
DoTS DT.110538635, DT.91300130, DT.40137340, DT.101363223
NIA Mouse Gene Index U033240
Consensus CDS Project CCDS25212.1
International Mouse Phenotyping Consortium Status Rad51c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001261 VEGA Gene Model | MGI Sequence Detail 28310 C57BL/6J ±  kb
transcript OTTMUST00000002513 VEGA | MGI Sequence Detail 1632 Not Applicable 
polypeptide OTTMUSP00000001238 VEGA | MGI Sequence Detail 384 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013632 DNA recombination and repair protein Rad51, C-terminal
InterPro IPR016467 DNA recombination and repair protein, RecA-like
InterPro IPR020588 DNA recombination/repair protein RecA/RadB, ATP-binding domain
InterPro IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000013675 DNA repair protein RAD51 homolog 3
References
(Earliest) J:70804 Leasure CS, et al., Sequence, chromosomal location and expression analysis of the murine homologue of human RAD51L2/RAD51C. Gene. 2001 Jun 13;271(1):59-67
(Latest) J:216440 Tumiati M, et al., Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53-mutant mice. J Pathol. 2015 Jan;235(1):136-46
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory