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Spred1
Gene Detail
Symbol

Name
ID
Spred1
sprouty protein with EVH-1 domain 1, related sequence
MGI:2150016
Synonyms
5730461F13Rik, Spred-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
59.03 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:117121374-117182279 bp, + strand
From VEGA annotation of GRCm38

  60906 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:24919  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SPRED1
Protein SuperFamily: sprouty-related protein Spred
Gene Tree: Spred1

Human
homologs
SPRED1, sprouty-related, EVH1 domain containing 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 161742
neXtProt AC: NX_Q7Z699

Human Synonyms: hSpred1, NFLS, PPP1R147, spred-1

Human Chr (Location): 15q14; chr15:38252087-38357249 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SPRED1

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(16) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display increased airway hyperresponsiveness, eosinophilia, a kinked tail, shortened face, impaired spatial learning and memory, and altered CNS transmission.
 
Human Diseases Modeled in Mice Using Spred1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Spred1 interacts with 468 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process inactivation of MAPK activity, multicellular organismal development, ...
Component cytoplasm, membrane, ...
Function phosphatase binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (49)    Tissues (30)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
Western blot 6
RT-PCR 4
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase spred1 ; ZFIN spred1    NEW 
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000015239 (Evidence)
Ensembl Gene Model ENSMUSG00000027351 (Evidence)
Entrez Gene 114715 (Evidence)
DFCI TC1590471, TC1580263, TC1608688, TC1606065, TC1602368
DoTS DT.91336476, DT.40140896
Consensus CDS Project CCDS16570.1, CCDS71115.1
International Mouse Phenotyping Consortium Status Spred1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015239 VEGA Gene Model | MGI Sequence Detail 60906 C57BL/6J ±  kb
transcript OTTMUST00000036098 VEGA | MGI Sequence Detail 6016 Not Applicable 
polypeptide OTTMUSP00000016218 VEGA | MGI Sequence Detail 444 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(155 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023337 c-Kit-binding domain
InterPro IPR000697 EVH1
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR007875 Sprouty
Protein Ontology PR:000015568 sprouty-related, EVH1 domain-containing protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185345 Stowe IB, et al., A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. Genes Dev. 2012 Jul 1;26(13):1421-6
All references(46)
Disease annotation references (1)
Other
accession IDs
MGI:1917839, MGI:2139136, MGI:2139276

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory