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Ferd3l Gene Detail
Summary
  • Symbol
    Ferd3l
  • Name
    Fer3 like bHLH transcription factor
  • Synonyms
    bHLHa31, fer3, Mnato3, Nato3, N-twist
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150010
    NCBI Gene: 114712
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:33928425-33929310 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 14.79 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150010
protein coding gene Chr12:33928425-33929310 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019677
protein coding gene Chr12:32034423-32035308 (+)
A/J MGP_AJ_G0019643
protein coding gene Chr12:31076488-31077373 (+)
AKR/J MGP_AKRJ_G0019615
protein coding gene Chr12:32062216-32063101 (+)
BALB/cJ MGP_BALBcJ_G0019621
protein coding gene Chr12:31265680-31266565 (+)
C3H/HeJ MGP_C3HHeJ_G0019425
protein coding gene Chr12:31909732-31910617 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020068
protein coding gene Chr12:32971026-32971911 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017693
protein coding gene Chr12:30279286-30280167 (+)
CAST/EiJ MGP_CASTEiJ_G0018980
protein coding gene Chr12:26979658-26980543 (+)
CBA/J MGP_CBAJ_G0019397
protein coding gene Chr12:34022183-34023068 (+)
DBA/2J MGP_DBA2J_G0019510
protein coding gene Chr12:30875105-30875990 (+)
FVB/NJ MGP_FVBNJ_G0019500
protein coding gene Chr12:30647087-30647972 (+)
LP/J MGP_LPJ_G0019580
protein coding gene Chr12:32098844-32099729 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019536
protein coding gene Chr12:33692474-33693359 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020108
protein coding gene Chr12:31555427-31556312 (+)
PWK/PhJ MGP_PWKPhJ_G0018747
protein coding gene Chr12:25632671-25633556 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018535
protein coding gene Chr12:26226227-26227111 (+)
WSB/EiJ MGP_WSBEiJ_G0019029
protein coding gene Chr12:31809506-31810391 (+)



Homology
more
  • Human Ortholog
    FERD3L, Fer3 like bHLH transcription factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FERD3L, Fer3 like bHLH transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHa31, NATO3, NTWIST, N-TWIST, PTFB
  • Links
    NCBI Gene ID: 222894
    neXtProt AC: NX_Q96RJ6
    UniProt: Q96RJ6

  • Chr Location
    7p21.1; chr7:19144782-19145421 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired caudal neural tube floor plate neuron maturation and reduced mesencephalic dopaminergic neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114712 NCBI Gene Model | MGI Sequence Detail 886 C57BL/6J ±  kb
    transcript NM_033522 RefSeq | MGI Sequence Detail 886 129/Sv  
    polypeptide Q923Z4 UniProt | EBI | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 6
      Primer pair 3
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 11
      Gene Ontology 4
      Phenotypes 2
    • Earliest
      J:70806 Segev E, et al., Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse. Mech Dev. 2001 Aug;106(1-2):197-202
    • Latest
      J:239291 Metzakopian E, et al., Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells. Development. 2015 Apr 01;142(7):1315-24

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/26/2019
    MGI 6.14
    The Jackson Laboratory