Ferd3l MGI Mouse Gene Detail - MGI:2150010 - Fer3 like bHLH transcription factor

Symbol

Ferd3l
Name

Fer3 like bHLH transcription factor
Synonyms

bHLHa31, fer3, Mnato3, Nato3, N-twist

Feature Type

protein coding gene
IDs

MGI:2150010
NCBI Gene: 114712
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:33978424-33979309 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 14.79 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

84 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2150010	protein coding gene	Chr12:33978424-33979309 (+)
129S1/SvImJ	ENSMUSG00200014696	protein coding gene	Chr12:25798005-25798890 (+)
A/J	ENSMUSG00195021516	protein coding gene	Chr12:28480854-28481739 (+)
AKR/J	ENSMUSG00220029692	protein coding gene	Chr12:26449271-26450156 (+)
BALB/cJ	ENSMUSG00180023144	protein coding gene	Chr12:27479854-27480739 (+)
C3H/HeJ	ENSMUSG00175021574	protein coding gene	Chr12:30513126-30514011 (+)
C57BL/6NJ	ENSMUSG00215015314	protein coding gene	Chr12:26905978-26906863 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017693	protein coding gene	Chr12:30279286-30280167 (+)
CAST/EiJ	ENSTCUG00005010078	protein coding gene	Chr12:27312826-27313711 (+)
CBA/J	ENSMUSG00210007613	protein coding gene	Chr12:27002350-27003235 (+)
DBA/2J	ENSMUSG00185014571	protein coding gene	Chr12:29019088-29019973 (+)
FVB/NJ	ENSMUSG00205006055	protein coding gene	Chr12:27078116-27079001 (+)
JF1/MsJ	ENSUMUG00000009445	protein coding gene	Chr12:33252823-33253708 (+)
LP/J	ENSMUSG00230020483	protein coding gene	Chr12:35970983-35971868 (+)
NOD/ShiLtJ	ENSMUSG00190017192	protein coding gene	Chr12:25955730-25956615 (+)
NZO/HlLtJ	ENSMUSG00225030588	protein coding gene	Chr12:38186623-38187508 (+)
PWK/PhJ	ENSLUMG00010011144	protein coding gene	Chr12:27465783-27466668 (+)
SPRET/EiJ	ENSMSPG00010005507	protein coding gene	Chr12:28120080-28120961 (+)
WSB/EiJ	ENSIUOG00005020311	protein coding gene	Chr12:26702782-26703667 (+)

Human Ortholog

FERD3L, Fer3 like bHLH transcription factor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FERD3L, Fer3 like bHLH transcription factor
Synonyms

bHLHa31, NATO3, N-TWIST, NTWIST, PTFB
Links

HGNC:16660

NCBI Gene ID: 222894

UniProt: Q96RJ6
Chr Location

7p21.1; chr7:19144782-19145421 (-) GRCh38

MGI Vertebrate Homology

Ferd3l stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FERD3L
Gene Tree

Ferd3l

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired caudal neural tube floor plate neuron maturation and reduced mesencephalic dopaminergic neurons.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

80
cDNA Data

6
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FERD3L

Xenbase ferd3l

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS25878.1

Ensembl

ENSMUSG00000046518 (Evidence)
NCBI Gene

114712

			Length	Strain/Species	Flank
genomic	114712	NCBI Gene Model \| MGI Sequence Detail	886	C57BL/6J	± kb
transcript	NM_033522	RefSeq \| MGI Sequence Detail	886	129/Sv
polypeptide	Q923Z4	UniProt \| EBI \| MGI Sequence Detail	168	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007462 Fer3-like protein

(term hierarchy)
InterPro Domains

IPR050283 E-box Binding Transcriptional Regulators

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

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All nucleic 12

Genomic 1

cDNA 6

Primer pair 4

Other 1

Microarray probesets 2

Summaries

All 36

Developmental Gene Expression 12

Gene Ontology 8

Phenotypes 4
Earliest

J:70806 Segev E, et al., Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse. Mech Dev. 2001 Aug;106(1-2):197-202
Latest

J:322870 Miozzo F, et al., Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Nat Commun. 2022 Mar 17;13(1):1426

TSS for Ferd3l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113203	Chr12:33978401-33978406 (+)	-20 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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