Pawr MGI Mouse Gene Detail - MGI:2149961 - PRKC, apoptosis, WT1, regulator

Symbol

Pawr
Name

PRKC, apoptosis, WT1, regulator
Synonyms

2310001G03Rik, Par4, Par-4

Feature Type

protein coding gene
IDs

MGI:2149961
NCBI Gene: 114774
Gene Overview

MyGene.info: PAWR
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:108332121-108414240 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 56.43 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

390 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2149961	protein coding gene	Chr10:108332121-108414391 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017713	protein coding gene	Chr10:110577761-110664721 (+)
A/J	MGP_AJ_G0017690	protein coding gene	Chr10:106417110-106501404 (+)
AKR/J	MGP_AKRJ_G0017652	protein coding gene	Chr10:109509069-109593981 (+)
BALB/cJ	MGP_BALBcJ_G0017654	protein coding gene	Chr10:106800190-106884426 (+)
C3H/HeJ	MGP_C3HHeJ_G0017479	protein coding gene	Chr10:109624259-109709350 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018111	protein coding gene	Chr10:114420897-114509304 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015790	protein coding gene	Chr10:101319677-101405206 (+)
CAST/EiJ	MGP_CASTEiJ_G0017040	protein coding gene	Chr10:109733960-109820234 (+)
CBA/J	MGP_CBAJ_G0017448	protein coding gene	Chr10:118866388-118954299 (+)
DBA/2J	MGP_DBA2J_G0017553	protein coding gene	Chr10:105555941-105637692 (+)
FVB/NJ	MGP_FVBNJ_G0017547	protein coding gene	Chr10:104549530-104632171 (+)
LP/J	MGP_LPJ_G0017627	protein coding gene	Chr10:111202174-111288756 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017576	protein coding gene	Chr10:121462994-121550480 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018149	protein coding gene	Chr10:109506265-109596564 (+)
PWK/PhJ	MGP_PWKPhJ_G0016822	protein coding gene	Chr10:105627719-105712436 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016612	protein coding gene	Chr10:108289787-108379721 (+)
WSB/EiJ	MGP_WSBEiJ_G0017100	protein coding gene	Chr10:109642846-109730805 (+)

Human Ortholog

PAWR, pro-apoptotic WT1 regulator

Vertebrate Orthologs

10

Human Ortholog

PAWR, pro-apoptotic WT1 regulator
Orthology source: HomoloGene, HGNC
Synonyms

Par-4, PAR4
Links

HGNC:8614

NCBI Gene ID: 5074

neXtProt AC: NX_Q96IZ0

UniProt: Q96IZ0
Chr Location

12q21.2; chr12:79587791-79691097 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1940
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PAWR
Gene Tree

Pawr

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Phenotype Summary

14 phenotypes from 6 alleles in 6 genetic backgrounds
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Gene trapped

24
Targeted

9
Genomic Mutations

1 involving Pawr
Incidental Mutations

CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene show lower levels of apoptosis and increased proliferation of both T cells and B cells.

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All GO Annotations

51
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

131
Tissues

48
cDNA Data

31
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pawr

ZFIN pawr

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Pawr interacts with 148 markers (Mir7-1, Mir23a, Mir23b, ...) View All

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All Sequences

42
RefSeq

2
UniProt

2
CCDS

CCDS36053.1
UniGene

391419

Ensembl

ENSMUSG00000035873 (Evidence)
NCBI Gene

114774

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035873	Ensembl Gene Model \| MGI Sequence Detail	82120	C57BL/6J	± kb
transcript	ENSMUST00000095313	Ensembl \| MGI Sequence Detail	1745	Not Applicable
polypeptide	ENSMUSP00000092951	Ensembl \| MGI Sequence Detail	333	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012313 PRKC apoptosis WT1 regulator protein

(term hierarchy)
InterPro Domains

IPR026117 Prostate apoptosis response 4

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All nucleic 32

cDNA 31

Primer pair 1

Microarray probesets 4

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MGI:1923677

Summaries

All 68

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 28
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:263907 McKenna MK, et al., Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemia. Blood. 2018 Jun 28;131(26):2943-2954

TSS for Pawr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95671	Chr10:108332112-108332159 (+)	15 bp
Tssr95672	Chr10:108332163-108332170 (+)	46 bp
Tssr95673	Chr10:108332173-108332182 (+)	57 bp
Tssr95674	Chr10:108332663-108332689 (+)	555 bp
Tssr95675	Chr10:108332694-108332743 (+)	598 bp
Tssr95676	Chr10:108333256-108333292 (+)	1,153 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/01/2019 MGI 6.14