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Pawr Gene Detail
Summary
  • Symbol
    Pawr
  • Name
    PRKC, apoptosis, WT1, regulator
  • Synonyms
    2310001G03Rik, Par4, Par-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149961
    NCBI Gene: 114774
  • Gene Overview
    MyGene.info: PAWR
Location & Maps
more
  • Sequence Map
    Chr10:108332189-108414391 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      82203 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 56.43 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PAWR, pro-apoptotic WT1 regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PAWR, pro-apoptotic WT1 regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Par-4, PAR4
  • Links
    NCBI Gene ID: 5074
    neXtProt AC: NX_Q96IZ0

  • Chr Location
    12q21; chr12:79587791-79691010 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 1940
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PAWR
  • Gene Tree
    Pawr
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 6 alleles in 6 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Targeted
    9
  • Genomic Mutations
    1 involving Pawr
  • Incidental Mutations
    CvDC
Mice homozygous for disruptions in this gene show lower levels of apoptosis and increased proliferation of both T cells and B cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    51
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    97
  • Tissues
    18
  • cDNA Data
    30
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 114774 NCBI Gene Model | MGI Sequence Detail 82203 C57BL/6J ±  kb
transcript NM_054056 RefSeq | MGI Sequence Detail 1828 C57BL/6  
polypeptide Q925B0 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    391 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012313 PRKC apoptosis WT1 regulator protein
  • InterPro Domains
    IPR026117 Prostate apoptosis response 4
Molecular
Reagents
less
  • All nucleic 33
    cDNA 30
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1923677
References
more
  • Summaries
    All 57
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 26
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:223262 Du WW, et al., The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4. J Cell Sci. 2015 Jan 15;128(2):293-304
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory