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Pawr Gene Detail
Summary
  • Symbol
    Pawr
  • Name
    PRKC, apoptosis, WT1, regulator
  • Synonyms
    2310001G03Rik, Par4, Par-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149961
    NCBI Gene: 114774
  • Gene Overview
    MyGene.info: PAWR
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr10:108332121-108414240 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      82120 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 56.43 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PAWR, pro-apoptotic WT1 regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PAWR, pro-apoptotic WT1 regulator
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Par-4, PAR4
  • Links
    NCBI Gene ID: 5074
    neXtProt AC: NX_Q96IZ0
    UniProt: Q96IZ0

  • Chr Location
    12q21.2; chr12:79587791-79691097 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 1940
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PAWR
  • Gene Tree
    Pawr
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 6 alleles in 6 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show lower levels of apoptosis and increased proliferation of both T cells and B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    131
  • Tissues
    48
  • cDNA Data
    31
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035873 Ensembl Gene Model | MGI Sequence Detail 82120 C57BL/6J ±  kb
    transcript ENSMUST00000095313 Ensembl | MGI Sequence Detail 1745 Not Applicable  
    polypeptide ENSMUSP00000092951 Ensembl | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      390 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923677
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:254044 Burikhanov R, et al., Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis. Cell Rep. 2017 Jan 10;18(2):508-519
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory