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Olig3 Gene Detail
Summary
  • Symbol
    Olig3
  • Name
    oligodendrocyte transcription factor 3
  • Synonyms
    Bhlhb7, bHLHe20
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149955
    NCBI Gene: 94222
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:19356539-19358604 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2066 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 8.33 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    OLIG3, oligodendrocyte transcription factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OLIG3, oligodendrocyte transcription factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Bhlhb7, bHLHe20
  • Links
    NCBI Gene ID: 167826
    neXtProt AC: NX_Q7RTU3
    UniProt: Q7RTU3

  • Chr Location
    6q23.3; chr6:137492199-137494394 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 14201
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OLIG3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit impaired development of class A neurons in the dorsal spinal cord, the alar plate, with reduced numbers of dI1 neurons and misspecified dI2 and dI3 neurons that assume the identity of class B neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94222 NCBI Gene Model | MGI Sequence Detail 2066 C57BL/6J ±  kb
    transcript NM_053008 RefSeq | MGI Sequence Detail 2066 C57BL/6  
    polypeptide Q6PFG8 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      24 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000011633 oligodendrocyte transcription factor 3
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR032659 Oligodendrocyte transcription factor 3
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 7
      Primer pair 1
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 44
      Gene Ontology 4
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:261199 Inagaki HK, et al., Low-Dimensional and Monotonic Preparatory Activity in Mouse Anterior Lateral Motor Cortex. J Neurosci. 2018 Apr 25;38(17):4163-4185

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory