About   Help   FAQ
Olig3 Gene Detail
Summary
  • Symbol
    Olig3
  • Name
    oligodendrocyte transcription factor 3
  • Synonyms
    Bhlhb7, bHLHe20
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149955
    NCBI Gene: 94222
Location & Maps
more
  • Sequence Map
    Chr10:19356560-19358606 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2047 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 8.33 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    OLIG3, oligodendrocyte transcription factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OLIG3, oligodendrocyte transcription factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Bhlhb7, bHLHe20
  • Links
    NCBI Gene ID: 167826
    neXtProt AC: NX_Q7RTU3

  • Chr Location
    6q23.3; chr6:137492199-137494394 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 14201
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: OLIG3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Olig3
Homozygous mutant mice exhibit impaired development of class A neurons in the dorsal spinal cord, the alar plate, with reduced numbers of dI1 neurons and misspecified dI2 and dI3 neurons that assume the identity of class B neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045591 Ensembl Gene Model | MGI Sequence Detail 2047 C57BL/6J ±  kb
transcript ENSMUST00000053225 Ensembl | MGI Sequence Detail 2047 Not Applicable  
polypeptide ENSMUSP00000057106 Ensembl | MGI Sequence Detail 273 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    24 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011633 oligodendrocyte transcription factor 3
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR032659 Oligodendrocyte transcription factor 3
Molecular
Reagents
less
  • All nucleic 10
    cDNA 6
    Primer pair 1
    Other 3

    Microarray probesets 2
References
more
  • Summaries
    All 55
    Developmental Gene Expression 38
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:70984 Takebayashi H, et al., Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. Mech Dev. 2000 Dec;99(1-2):143-8
  • Latest
    J:231976 Hashimoto H, et al., Keratan Sulfate Regulates the Switch from Motor Neuron to Oligodendrocyte Generation During Development of the Mouse Spinal Cord. Neurochem Res. 2016 Feb;41(1-2):450-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory