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Olig3 Gene Detail
Summary
  • Symbol
    Olig3
  • Name
    oligodendrocyte transcription factor 3
  • Synonyms
    Bhlhb7, bHLHe20
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149955
    NCBI Gene: 94222
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:19356539-19358604 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 8.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149955
protein coding gene Chr10:19356533-19358604 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017044
protein coding gene Chr10:17072703-17074753 (+)
A/J MGP_AJ_G0017022
protein coding gene Chr10:16426737-16428801 (+)
AKR/J MGP_AKRJ_G0016986
protein coding gene Chr10:16692836-16694886 (+)
BALB/cJ MGP_BALBcJ_G0016980
protein coding gene Chr10:16487430-16489478 (+)
C3H/HeJ MGP_C3HHeJ_G0016805
protein coding gene Chr10:17019229-17021291 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017442
protein coding gene Chr10:17498826-17500872 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015147
protein coding gene Chr10:15439730-15441792 (+)
CAST/EiJ MGP_CASTEiJ_G0016387
protein coding gene Chr10:16886744-16888806 (+)
CBA/J MGP_CBAJ_G0016777
protein coding gene Chr10:18289675-18291741 (+)
DBA/2J MGP_DBA2J_G0016885
protein coding gene Chr10:16307737-16309783 (+)
FVB/NJ MGP_FVBNJ_G0016880
protein coding gene Chr10:16068246-16070624 (+)
LP/J MGP_LPJ_G0016960
protein coding gene Chr10:16884791-16886849 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016910
protein coding gene Chr10:18552563-18554606 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017480
protein coding gene Chr10:16681084-16683130 (+)
PWK/PhJ MGP_PWKPhJ_G0016172
protein coding gene Chr10:16168524-16170663 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015955
protein coding gene Chr10:16840046-16842087 (+)
WSB/EiJ MGP_WSBEiJ_G0016449
protein coding gene Chr10:16783216-16785251 (+)



Homology
more
  • Human Ortholog
    OLIG3, oligodendrocyte transcription factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OLIG3, oligodendrocyte transcription factor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Bhlhb7, bHLHe20
  • Links
    NCBI Gene ID: 167826
    neXtProt AC: NX_Q7RTU3
    UniProt: Q7RTU3

  • Chr Location
    6q23.3; chr6:137492199-137494394 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 14201
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OLIG3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit impaired development of class A neurons in the dorsal spinal cord, the alar plate, with reduced numbers of dI1 neurons and misspecified dI2 and dI3 neurons that assume the identity of class B neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94222 NCBI Gene Model | MGI Sequence Detail 2066 C57BL/6J ±  kb
    transcript NM_053008 RefSeq | MGI Sequence Detail 2066 C57BL/6  
    polypeptide Q6PFG8 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000011633 oligodendrocyte transcription factor 3
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR032659 Oligodendrocyte transcription factor 3
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 7
      Primer pair 1
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 45
      Gene Ontology 4
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:261199 Inagaki HK, et al., Low-Dimensional and Monotonic Preparatory Activity in Mouse Anterior Lateral Motor Cortex. J Neurosci. 2018 Apr 25;38(17):4163-4185

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory