About   Help   FAQ
Gopc Gene Detail
Summary
  • Symbol
    Gopc
  • Name
    golgi associated PDZ and coiled-coil motif containing
  • Synonyms
    2210402P09Rik, GOPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149946
    NCBI Gene: 94221
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:52213120-52258220 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 26.54 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1119 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149946
 protein coding gene Chr10:52211946-52258220 (-)
129S1/SvImJ ENSMUSG00200007039
 protein coding gene Chr10:49108475-49155004 (-)
A/J ENSMUSG00195002791
 protein coding gene Chr10:49376450-49422978 (-)
AKR/J ENSMUSG00220005792
 protein coding gene Chr10:49064135-49110700 (-)
BALB/cJ ENSMUSG00180011643
 protein coding gene Chr10:49506109-49552640 (-)
C3H/HeJ ENSMUSG00175009842
 protein coding gene Chr10:49247206-49293741 (-)
C57BL/6NJ ENSMUSG00215002102
 protein coding gene Chr10:49011152-49057682 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015313
 protein coding gene Chr10:47201007-47245703 (-)
CAST/EiJ ENSTCUG00005008303
 protein coding gene Chr10:49213305-49253849 (-)
CBA/J ENSMUSG00210008068
 protein coding gene Chr10:49153062-49199591 (-)
DBA/2J ENSMUSG00185003186
 protein coding gene Chr10:49306628-49353158 (-)
FVB/NJ ENSMUSG00205004629
 protein coding gene Chr10:49222205-49268736 (-)
JF1/MsJ ENSUMUG00000022395
 protein coding gene Chr10:48970189-49015680 (-)
LP/J ENSMUSG00230018324
 protein coding gene Chr10:51108053-51154578 (-)
NOD/ShiLtJ ENSMUSG00190005464
 protein coding gene Chr10:49472708-49519223 (-)
NZO/HlLtJ ENSMUSG00225022133
 protein coding gene Chr10:55388990-55435516 (-)
PWK/PhJ ENSLUMG00010004181
 protein coding gene Chr10:49102229-49147841 (-)
SPRET/EiJ ENSMSPG00010012245
 protein coding gene Chr10:50455643-50501239 (-)
WSB/EiJ ENSIUOG00005014578
 protein coding gene Chr10:49111595-49158160 (-)



Homology
more
  • Human Ortholog
    GOPC, golgi associated PDZ and coiled-coil motif containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GOPC, golgi associated PDZ and coiled-coil motif containing
  • Synonyms
    CAL, dJ94G16.2, FIG, GOPC1, PIST
  • Links
    NCBI Gene ID: 57120
    UniProt: Q9HD26

  • Chr Location
    6q22.1; chr6:117560269-117602542 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gopc mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    2 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show male sterility with globozoospermia characterized by a complete lack of acrosomes due to failure of vesicle transport from the Golgi apparatus, a malformed sperm nucleus, and abnormal mitochondrial arrangement in the mitochondrial sheath of mutant spermatozoa.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    644
  • Tissues
    37
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94221 NCBI Gene Model | MGI Sequence Detail 45101 C57BL/6J ±  kb
    transcript NM_001199272 RefSeq | MGI Sequence Detail 4319 C57BL/6  
    polypeptide Q8BH60 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1913757, MGI:2143681
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 15
      Phenotypes 26
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory