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Gopc
Gene Detail
 Symbol
Name
ID
Gopc
golgi associated PDZ and coiled-coil motif containing
MGI:2149946
Synonyms 2210402P09Rik, GOPC1
Feature Type protein coding gene
Genetic Map
Chromosome 10
26.54 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:52337024-52382124 bp, - strand
From NCBI annotation of GRCm38

  45101 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10695  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gopc

Human
homologs
Human Homolog GOPC, golgi-associated PDZ and coiled-coil motif containing
NCBI Gene ID 57120
neXtProt AC  NX_Q9HD26
Human Synonyms  CAL, dJ94G16.2, FIG, GOPC1, PIST
Human Chr (Location)  6q21; chr6:117560269-117602542 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GOPC
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show male sterility with globozoospermia characterized by a complete lack of acrosomes due to failure of vesicle transport from the Golgi apparatus, a malformed sperm nucleus, and abnormal mitochondrial arrangement in the mitochondrial sheath of mutant spermatozoa.
 
Human Diseases Modeled Using Mouse Gopc (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Gopc interacts with 377 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process autophagy, protein homooligomerization, ...
Component cell junction, cell projection, ...
Function frizzled binding, ion channel binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (38)    Tissues (31)    Images (9)
Theiler Stages: 17, 20, 21
Assay TypeResults
RNA in situ 38
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000019861 (Evidence)
Entrez Gene94221 (Evidence)
DFCITC1580484, TC1589868, TC1598817, TC1613541
DoTSDT.101238025, DT.101324843, DT.101358914, DT.532590, DT.91572805
NIA Mouse Gene IndexU031775
Consensus CDS ProjectCCDS35898.1
International Mouse Knockout Project StatusGopc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 94221 NCBI Gene Model | MGI Sequence Detail 45101 C57BL/6J ±  kb
transcript NM_001199272 RefSeq | MGI Sequence Detail 4319 C57BL/6 
polypeptide Q8BH60 UniProt | EBI | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(230 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
Protein Ontology PR:000008147 golgi-associated PDZ and coiled-coil motif-containing protein
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187685 Fujihara Y, et al., SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Development. 2012 Oct;139(19):3583-9
All references(42)
Disease annotation references (1)
Other
accession IDs
MGI:1913757, MGI:2143681

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory