Gopc
Gene Detail

Symbol Name ID

Gopc golgi associated PDZ and coiled-coil motif containing MGI:2149946

Synonyms

2210402P09Rik, GOPC1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

26.54 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:52337024-52382124 bp, - strand From NCBI annotation of GRCm38   45101 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10695  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gopc

Human homologs

Human Homolog		GOPC, golgi-associated PDZ and coiled-coil motif containing
NCBI Gene ID		57120
neXtProt AC		NX_Q9HD26
Human Synonyms		CAL, dJ94G16.2, FIG, GOPC1, PIST
Human Chr (Location)		6q21; chr6:117881432-117923705 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GOPC

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a null allele show male sterility with globozoospermia characterized by a complete lack of acrosomes due to failure of vesicle transport from the Golgi apparatus, a malformed sperm nucleus, and abnormal mitochondrial arrangement in the mitochondrial sheath of mutant spermatozoa.

 
Human Diseases Modeled Using Mouse Gopc (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	autophagy, protein homooligomerization, ...
Component	cell junction, cell projection, ...
Function	frizzled binding, ion channel binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (38)    Tissues (31)    Images (9)
Theiler Stages: 17, 20, 21

Assay Type	Results
RNA in situ	38

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(13)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000019861 (Evidence)
Entrez Gene	94221 (Evidence)
DFCI	TC1580484, TC1589868, TC1598817, TC1613541
DoTS	DT.101238025, DT.101324843, DT.101358914, DT.532590, DT.91572805
NIA Mouse Gene Index	U031775
Consensus CDS Project	CCDS35898.1
International Mouse Knockout Project Status	Gopc

Sequences

Length	Strain/Species
genomic	94221	NCBI Gene Model | MGI Sequence Detail	45101	C57BL/6J
transcript	NM_001199272	RefSeq | MGI Sequence Detail	4319	C57BL/6
polypeptide	Q8BH60	UniProt | EBI | MGI Sequence Detail	463	Not Applicable

All sequences(41) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(197 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001478	PDZ domain
Protein Ontology	PR:000008147	golgi-associated PDZ and coiled-coil motif-containing protein

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187685 Fujihara Y, et al., SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Development. 2012 Oct;139(19):3583-9
All references(42)

Other accession IDs

MGI:1913757, MGI:2143681