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Gopc Gene Detail
Summary
  • Symbol
    Gopc
  • Name
    golgi associated PDZ and coiled-coil motif containing
  • Synonyms
    2210402P09Rik, GOPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149946
    NCBI Gene: 94221
  • Gene Overview
    MyGene.info: GOPC
Location & Maps
more
  • Sequence Map
    Chr10:52337024-52382124 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45101 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GOPC, golgi-associated PDZ and coiled-coil motif containing
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GOPC, golgi-associated PDZ and coiled-coil motif containing
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAL, dJ94G16.2, FIG, GOPC1, PIST
  • Links
    NCBI Gene ID: 57120
    neXtProt AC: NX_Q9HD26

  • Chr Location
    6q21; chr6:117560269-117602542 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Gopc mouse models

Human Disease Mouse Models
       Spermatogenic Failure 6; SPGF6   OMIM: 102530 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Gopc
  • Incidental Mutations
Mice homozygous for a null allele show male sterility with globozoospermia characterized by a complete lack of acrosomes due to failure of vesicle transport from the Golgi apparatus, a malformed sperm nucleus, and abnormal mitochondrial arrangement in the mitochondrial sheath of mutant spermatozoa.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 94221 NCBI Gene Model | MGI Sequence Detail 45101 C57BL/6J ±  kb
transcript NM_001199272 RefSeq | MGI Sequence Detail 4319 C57BL/6  
polypeptide Q8BH60 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    227 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008147 Golgi-associated PDZ and coiled-coil motif-containing protein
  • InterPro Domains
    IPR001478 PDZ domain
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 6
Other
Accession IDs
less
MGI:1913757, MGI:2143681
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:212946 Bauch C, et al., Subcellular sorting of the G-protein coupled mouse somatostatin receptor 5 by a network of PDZ-domain containing proteins. PLoS One. 2014;9(2):e88529

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory