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Nans Gene Detail
Summary
  • Symbol
    Nans
  • Name
    N-acetylneuraminic acid synthase (sialic acid synthase)
  • Synonyms
    4632418E04Rik, N-acetylneuraminic acid phosphate synthase, Sas
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149820
    NCBI Gene: 94181
  • Gene Overview
    MyGene.info: NANS
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:46489329-46503438 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 24.83 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149820
protein coding gene Chr4:46489248-46503632 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028259
protein coding gene Chr4:44809152-44823538 (+)
A/J MGP_AJ_G0028218
protein coding gene Chr4:43164387-43178774 (+)
AKR/J MGP_AKRJ_G0028168
protein coding gene Chr4:44216286-44230670 (+)
BALB/cJ MGP_BALBcJ_G0028238
protein coding gene Chr4:43266304-43280686 (+)
C3H/HeJ MGP_C3HHeJ_G0027959
protein coding gene Chr4:44826104-44841029 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028679
protein coding gene Chr4:46462589-46478318 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025988
protein coding gene Chr4:40543806-40558965 (+)
CAST/EiJ MGP_CASTEiJ_G0027398
protein coding gene Chr4:44380812-44397514 (+)
CBA/J MGP_CBAJ_G0027925
protein coding gene Chr4:47945370-47959709 (+)
DBA/2J MGP_DBA2J_G0028075
protein coding gene Chr4:43054199-43068824 (+)
FVB/NJ MGP_FVBNJ_G0028042
protein coding gene Chr4:42303465-42317848 (+)
LP/J MGP_LPJ_G0028174
protein coding gene Chr4:44860197-44874647 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028066
protein coding gene Chr4:51017466-51032197 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028714
protein coding gene Chr4:44437474-44452899 (+)
PWK/PhJ MGP_PWKPhJ_G0027123
protein coding gene Chr4:43158776-43173371 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026951
protein coding gene Chr4:43941406-43958004 (+)
WSB/EiJ MGP_WSBEiJ_G0027476
protein coding gene Chr4:44349875-44364269 (+)



Homology
more
  • Human Ortholog
    NANS, N-acetylneuraminate synthase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NANS, N-acetylneuraminate synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-100, SAS, SEMDCG, SEMDG
  • Links
    NCBI Gene ID: 54187
    neXtProt AC: NX_Q9NR45
    UniProt: Q9NR45

  • Chr Location
    9q22.33; chr9:98056677-98083083 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 94181 NCBI Gene Model | MGI Sequence Detail 14110 C57BL/6J ±  kb
transcript NM_053179 RefSeq | MGI Sequence Detail 1904 C57BL/6  
polypeptide Q99J77 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 115
    cDNA 113
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918061, MGI:2140633
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:63317 Nakata D, et al., Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity. Biochem Biophys Res Commun. 2000 Jul 5;273(2):642-8
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory