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Oas1c Gene Detail
Summary
  • Symbol
    Oas1c
  • Name
    2'-5' oligoadenylate synthetase 1C
  • Synonyms
    Oasl5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149633
    NCBI Gene: 114643
Location & Maps
more
  • Sequence Map
    Chr5:120800194-120812514 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12321 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Vertebrate Orthologs
    3
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
    Orthology source: HGNC
  • Synonyms
    IFI-4, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    neXtProt AC: NX_P00973

  • Chr Location
    12q24.2; chr12:112906934-112932049 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human OAS1 associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Oas1c
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026817 VEGA Gene Model | MGI Sequence Detail 12321 C57BL/6J ±  kb
transcript OTTMUST00000066317 VEGA | MGI Sequence Detail 2291 Not Applicable  
polypeptide OTTMUSP00000033220 VEGA | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR026774 2'-5'-oligoadenylate synthase
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR006116 2-5-oligoadenylate synthetase, N-terminal
Molecular
Reagents
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  • All nucleic 29
    Genomic 3
    cDNA 26

    Microarray probesets 3
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:70792 Shibata S, et al., Cloning of a novel 2',5'-oligoadenylate synthetase-like molecule, Oasl5 in mice. Gene. 2001 Jun 27;271(2):261-71
  • Latest
    J:192649 Kristiansen H, et al., The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res. 2011 Jan;31(1):41-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory