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Tle6 Gene Detail
Summary
  • Symbol
    Tle6
  • Name
    transducin-like enhancer of split 6
  • Synonyms
    1810057E06Rik, Grg6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149593
    NCBI Gene: 114606
Location & Maps
more
  • Sequence Map
    Chr10:81590904-81601073 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10170 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TLE6, transducin like enhancer of split 6
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TLE6, transducin like enhancer of split 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GRG6, PREMBL
  • Links
    NCBI Gene ID: 79816
    neXtProt AC: NX_Q9H808

  • Chr Location
    19p13.3; chr19:2977415-2995184 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TLE6 associations

Human Disease Mouse Models
       Preimplantation Embryonic Lethality; PREMBL   OMIM: 616814
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from multigenic genotypes
    14 phenotype references
  • All Mutations and Alleles
    40
  • Chemically induced (other)
    1
  • Gene trapped
    34
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Tle6
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027830 VEGA Gene Model | MGI Sequence Detail 10170 C57BL/6J ±  kb
transcript OTTMUST00000068886 VEGA | MGI Sequence Detail 2015 Not Applicable  
polypeptide OTTMUSP00000034915 VEGA | MGI Sequence Detail 581 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    21 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016376 transducin-like enhancer protein 6
  • InterPro Domains
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 56
    cDNA 54
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917049
References
more
  • Summaries
    All 40
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:210340 Duncan FE, et al., Transducin-like enhancer of split-6 (TLE6) is a substrate of protein kinase A activity during mouse oocyte maturation. Biol Reprod. 2014 Mar;90(3):63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory