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Slc5a5 Gene Detail
Summary
  • Symbol
    Slc5a5
  • Name
    solute carrier family 5 (sodium iodide symporter), member 5
  • Synonyms
    NIS
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149330
    NCBI Gene: 114479
  • Gene Overview
    MyGene.info: SLC5A5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:70882889-70892757 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9869 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.36 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC5A5, solute carrier family 5 member 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC5A5, solute carrier family 5 member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NIS, TDH1
  • Links
    NCBI Gene ID: 6528
    neXtProt AC: NX_Q92911
    UniProt: Q92911

  • Chr Location
    19p13.11; chr19:17871394-17895175 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced T3 and T4 levels when fed a minimal iodine diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026286 VEGA Gene Model | MGI Sequence Detail 9869 C57BL/6J ±  kb
    transcript OTTMUST00000065025 VEGA | MGI Sequence Detail 2928 Not Applicable  
    polypeptide OTTMUSP00000032353 VEGA | MGI Sequence Detail 618 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      109 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR038377 Sodium/glucose symporter superfamily
      IPR035689 Sodium/iodide cotransporter
      IPR001734 Sodium/solute symporter
      IPR018212 Sodium/solute symporter, conserved site
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 12
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:70334 Perron B, et al., Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. J Endocrinol. 2001 Jul;170(1):185-96
    • Latest
      J:250121 Ferrandino G, et al., An extremely high dietary iodide supply forestalls severe hypothyroidism in Na+/I- symporter (NIS) knockout mice. Sci Rep. 2017 Jul 13;7(1):5329

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory