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Slc5a5 Gene Detail
Summary
  • Symbol
    Slc5a5
  • Name
    solute carrier family 5 (sodium iodide symporter), member 5
  • Synonyms
    NIS
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149330
    NCBI Gene: 114479
  • Gene Overview
    MyGene.info: SLC5A5
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70882889-70892757 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.36 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149330
protein coding gene Chr8:70882885-70893052 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033733
protein coding gene Chr8:71197490-71207684 (-)
A/J MGP_AJ_G0033716
protein coding gene Chr8:68288691-68298557 (-)
AKR/J MGP_AKRJ_G0033641
protein coding gene Chr8:70260931-70270793 (-)
BALB/cJ MGP_BALBcJ_G0033712
protein coding gene Chr8:68522704-68532555 (-)
C3H/HeJ MGP_C3HHeJ_G0033422
protein coding gene Chr8:70894400-70904449 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034229
protein coding gene Chr8:73872742-73886324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031172
protein coding gene Chr8:63107149-63117192 (-)
CAST/EiJ MGP_CASTEiJ_G0032747
protein coding gene Chr8:70372356-70383943 (-)
CBA/J MGP_CBAJ_G0033400
protein coding gene Chr8:76535149-76544965 (-)
DBA/2J MGP_DBA2J_G0033554
protein coding gene Chr8:68008245-68018098 (-)
FVB/NJ MGP_FVBNJ_G0033495
protein coding gene Chr8:67147367-67158059 (-)
LP/J MGP_LPJ_G0033641
protein coding gene Chr8:71211722-71223727 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033538
protein coding gene Chr8:79168167-79178269 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034247
protein coding gene Chr8:70431107-70442045 (-)
PWK/PhJ MGP_PWKPhJ_G0032454
protein coding gene Chr8:67305714-67315571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032291
protein coding gene Chr8:69407075-69417223 (-)
WSB/EiJ MGP_WSBEiJ_G0032862
protein coding gene Chr8:70794064-70803963 (-)



Homology
more
  • Human Ortholog
    SLC5A5, solute carrier family 5 member 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC5A5, solute carrier family 5 member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NIS, TDH1
  • Links
    NCBI Gene ID: 6528
    neXtProt AC: NX_Q92911
    UniProt: Q92911

  • Chr Location
    19p13.11; chr19:17871394-17895175 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced T3 and T4 levels when fed a minimal iodine diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000792 Ensembl Gene Model | MGI Sequence Detail 9869 C57BL/6J ±  kb
    transcript ENSMUST00000000809 Ensembl | MGI Sequence Detail 2928 Not Applicable  
    polypeptide ENSMUSP00000000809 Ensembl | MGI Sequence Detail 618 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR038377 Sodium/glucose symporter superfamily
      IPR035689 Sodium/iodide cotransporter
      IPR001734 Sodium/solute symporter
      IPR018212 Sodium/solute symporter, conserved site
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:70334 Perron B, et al., Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. J Endocrinol. 2001 Jul;170(1):185-96
    • Latest
      J:252897 Ferrandino G, et al., Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9172-E9180

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory