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Slc5a5
Gene Detail
Symbol

Name
ID
Slc5a5
solute carrier family 5 (sodium iodide symporter), member 5
MGI:2149330
Synonyms
NIS
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.36 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:70882889-70892757 bp, - strand
From VEGA annotation of GRCm38

  9869 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37311  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc5a5

Human
homologs
Human Homolog SLC5A5, solute carrier family 5 (sodium/iodide cotransporter), member 5
NCBI Gene ID 6528
neXtProt AC  NX_Q92911
Human Synonyms  NIS, TDH1
Human Chr (Location)  19p13.11; chr19:17871832-17895174 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC5A5
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Slc5a5 interacts with 135 markers (Mir18, Mir18b, Mir22, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (14)    Tissues (8)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026286 (Evidence)
Ensembl Gene ModelENSMUSG00000000792 (Evidence)
Entrez Gene114479 (Evidence)
UniGene172923
DFCITC1586534, TC1634520
DoTSDT.528007
NIA Mouse Gene IndexU029935
Consensus CDS ProjectCCDS22385.1
International Mouse Knockout Project StatusSlc5a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026286 VEGA Gene Model | MGI Sequence Detail 9869 C57BL/6J ±  kb
transcript OTTMUST00000065025 VEGA | MGI Sequence Detail 2928 Not Applicable 
polypeptide OTTMUSP00000032353 VEGA | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001734 Sodium/solute symporter
InterPro IPR018212 Sodium/solute symporter, conserved site
InterPro IPR019900 Sodium/solute symporter, subgroup
Protein Ontology PR:000015171 sodium/iodide cotransporter
References
(Earliest) J:70334 Perron B, et al., Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. J Endocrinol. 2001 Jul;170(1):185-96
(Latest) J:201463 Watson LA, et al., Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory