Slc5a5
Gene Detail

Symbol Name ID

Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 MGI:2149330

Synonyms

NIS

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.36 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:70882889-70892757 bp, - strand From VEGA annotation of GRCm38   9869 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37311  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc5a5

Human homologs

Human Homolog		SLC5A5, solute carrier family 5 (sodium iodide symporter), member 5
NCBI Gene ID		6528
neXtProt AC		NX_Q92911
Human Synonyms		NIS, TDH1
Human Chr (Location)		19p13.11; chr19:17982782-18005983 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC5A5

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	anion transport, iodide transport, ...
Component	integral to membrane, membrane, ...
Function	iodide transmembrane transporter activity, sodium:iodide symporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (14)    Tissues (8)    Images (8)
Theiler Stages: 20, 22, 23, 25

Assay Type	Results
RNA in situ	14

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026286 (Evidence)
Ensembl Gene Model	ENSMUSG00000000792 (Evidence)
Entrez Gene	114479 (Evidence)
UniGene	172923
DFCI	TC1586534, TC1634520
DoTS	DT.528007
NIA Mouse Gene Index	U029935
Consensus CDS Project	CCDS22385.1
International Mouse Knockout Project Status	Slc5a5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026286	VEGA Gene Model | MGI Sequence Detail	9869	C57BL/6J
transcript	OTTMUST00000065025	VEGA | MGI Sequence Detail	2928	Not Applicable
polypeptide	OTTMUSP00000032353	VEGA | MGI Sequence Detail	618	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(48 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001734	Sodium/solute symporter
InterPro	IPR018212	Sodium/solute symporter, conserved site
InterPro	IPR019900	Sodium/solute symporter, subgroup
Protein Ontology	PR:000015171	sodium/iodide cotransporter

References

(Earliest) J:70334 Perron B, et al., Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. J Endocrinol. 2001 Jul;170(1):185-96
(Latest) J:181140 Frezzetti D, et al., The microRNA-processing enzyme Dicer is essential for thyroid function. PLoS One. 2011;6(11):e27648
All references(38)