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Slc5a5 Gene Detail
Summary
  • Symbol
    Slc5a5
  • Name
    solute carrier family 5 (sodium iodide symporter), member 5
  • Synonyms
    NIS
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149330
    NCBI Gene: 114479
  • Gene Overview
    MyGene.info: SLC5A5
Location & Maps
more
  • Sequence Map
    Chr8:70882889-70892757 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9869 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.36 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC5A5, solute carrier family 5 member 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC5A5, solute carrier family 5 member 5
    Orthology source: HomoloGene
  • Synonyms
    NIS, TDH1
  • Links
    NCBI Gene ID: 6528
    neXtProt AC: NX_Q92911

  • Chr Location
    19p13.11; chr19:17871411-17895174 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC5A5 associations

Human Disease Mouse Models
       Thyroid Dyshormonogenesis 1; TDH1   OMIM: 274400
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Slc5a5
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026286 VEGA Gene Model | MGI Sequence Detail 9869 C57BL/6J ±  kb
transcript OTTMUST00000065025 VEGA | MGI Sequence Detail 2928 Not Applicable  
polypeptide OTTMUSP00000032353 VEGA | MGI Sequence Detail 618 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    109 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015171 sodium/iodide cotransporter
  • InterPro Domains
    IPR001734 Sodium/solute symporter
    IPR018212 Sodium/solute symporter, conserved site
Molecular
Reagents
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  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 38
    Developmental Gene Expression 11
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:70334 Perron B, et al., Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. J Endocrinol. 2001 Jul;170(1):185-96
  • Latest
    J:220108 Marotta P, et al., The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells. Mol Cell Endocrinol. 2014 Oct;396(1-2):26-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory