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Otoa
Gene Detail
 Symbol
Name
ID
Otoa
otoancorin
MGI:2149209
Feature Type protein coding gene
Genetic Map
Chromosome 7
65.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:121083322-121163097 bp, + strand
From VEGA annotation of GRCm38

  79776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:71803  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Otoa

Human
homologs
Human Homolog OTOA, otoancorin
NCBI Gene ID 146183
neXtProt AC  NX_Q7RTW8
Human Synonyms  CT108, DFNB22
Human Chr (Location)  16p12.2; chr16:21678514-21760729 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human OTOA
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit hearing loss, detachment of the tectorial membrane from the spiral limbus, abnormal tectorial membrane morphology, absence of Hensen's stripe and increased cochlear nerve coumpond action potential threshold.
 
Human Diseases Modeled Using Mouse Otoa (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Otoa interacts with 43 markers (Mir18, Mir103-1, Mir103-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell-matrix adhesion, sensory perception of sound, ...
Component anchored component of membrane, apical plasma membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (25)    Tissues (14)    Images (15)
Theiler Stages: 23, 24, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 7
RT-PCR 10
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000036710 (Evidence)
Ensembl Gene ModelENSMUSG00000034990 (Evidence)
Entrez Gene246190 (Evidence)
UniGene221073
DFCITC1585443, TC1613964
DoTSDT.101298368, DT.91304940, DT.97332647
Consensus CDS ProjectCCDS40114.1
International Mouse Knockout Project StatusOtoa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036710 VEGA Gene Model | MGI Sequence Detail 79776 C57BL/6J ±  kb
transcript OTTMUST00000094051 VEGA | MGI Sequence Detail 3773 Not Applicable 
polypeptide OTTMUSP00000052245 VEGA | MGI Sequence Detail 1137 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(10) UniProt(5)
Polymorphisms SNPs within 2kb(557 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026663 Otoancorin
InterPro IPR026664 Stereocilin related
Protein Ontology PR:000012071 otoancorin
References (Earliest) J:76334 Zwaenepoel I, et al., Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6240-5
(Latest) J:196582 Romand R, et al., Retinoic acid deficiency impairs the vestibular function. J Neurosci. 2013 Mar 27;33(13):5856-66
All references(27)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory