About   Help   FAQ
Otoa Gene Detail
Summary
  • Symbol
    Otoa
  • Name
    otoancorin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149209
    NCBI Gene: 246190
Location & Maps
more
  • Sequence Map
    Chr7:121081650-121163097 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      81448 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 65.07 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    OTOA, otoancorin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OTOA, otoancorin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT108, DFNB22
  • Links
    NCBI Gene ID: 146183
    neXtProt AC: NX_Q7RTW8

  • Chr Location
    16p12.2; chr16:21664155-21760729 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 71803
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OTOA
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Otoa mouse models; 1 with human OTOA associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 22; DFNB22   OMIM: 607039 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hearing loss, detachment of the tectorial membrane from the spiral limbus, abnormal tectorial membrane morphology, absence of Hensen's stripe and increased cochlear nerve coumpond action potential threshold.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036710 VEGA Gene Model | MGI Sequence Detail 81448 C57BL/6J ±  kb
transcript OTTMUST00000094051 VEGA | MGI Sequence Detail 3773 Not Applicable  
polypeptide OTTMUSP00000052245 VEGA | MGI Sequence Detail 1137 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    565 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:76334 Zwaenepoel I, et al., Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6240-5
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory