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Otoa
Gene Detail
Symbol

Name
ID
Otoa
otoancorin
MGI:2149209
Feature Type
protein coding gene
Genetic Map
Chromosome 7
65.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:121083322-121163097 bp, + strand
From VEGA annotation of GRCm38

  79776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:71803  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: OTOA
Gene Tree: Otoa

Human
homologs
OTOA, otoancorin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 146183
neXtProt AC: NX_Q7RTW8

Human Synonyms: CT108, DFNB22

Human Chr (Location): 16p12.2; chr16:21664155-21760729 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human OTOA

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit hearing loss, detachment of the tectorial membrane from the spiral limbus, abnormal tectorial membrane morphology, absence of Hensen's stripe and increased cochlear nerve coumpond action potential threshold.
 
Human Diseases Modeled in Mice Using Otoa (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Otoa interacts with 43 markers (Mir18, Mir103-1, Mir103-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell-matrix adhesion, sensory perception of sound, ...
Component anchored component of membrane, apical plasma membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (25)    Tissues (15)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 7
RT-PCR 10
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000036710 (Evidence)
Ensembl Gene Model ENSMUSG00000034990 (Evidence)
Entrez Gene 246190 (Evidence)
UniGene 221073
DFCI TC1585443, TC1613964
DoTS DT.101298368, DT.91304940, DT.97332647
Consensus CDS Project CCDS40114.1
International Mouse Phenotyping Consortium Status Otoa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036710 VEGA Gene Model | MGI Sequence Detail 79776 C57BL/6J ±  kb
transcript OTTMUST00000094051 VEGA | MGI Sequence Detail 3773 Not Applicable 
polypeptide OTTMUSP00000052245 VEGA | MGI Sequence Detail 1137 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(20) UniProt(5)
Polymorphisms
SNPs within 2kb(557 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026663 Otoancorin
InterPro IPR026664 Stereocilin related
Protein Ontology PR:000012071 otoancorin
References
(Earliest) J:76334 Zwaenepoel I, et al., Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6240-5
(Latest) J:218509 Kim HJ, et al., Patterns of gene expression associated with Pten deficiency in the developing inner ear. PLoS One. 2014;9(6):e97544
All references(28)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory