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Unc13c
Gene Detail
Symbol

Name
ID
Unc13c
unc-13 homolog C (C. elegans)
MGI:2149021
Synonyms
1500037O19Rik, D9Ertd414e, MGC:40770, Munc13-3, Unc13h3
Feature Type
protein coding gene
Genetic Map
Chromosome 9
40.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:73479422-73968966 bp, - strand
From VEGA annotation of GRCm38

  489545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Unc13c

Human
homologs
Human Homolog UNC13C, unc-13 homolog C (C. elegans)
NCBI Gene ID 440279
neXtProt AC  NX_Q8NB66
Human Chr (Location)  15q21.3; chr15:53978362-54628608 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice demonstrate an impaired ability to learn complex motor tasks, putatively due to an observed increase in paired-pulse facilitation.
 
Interactions
Unc13c interacts with 62 markers (Mir7-1, Mir7-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process exocytosis, intracellular signal transduction, ...
Component cell junction, cytoplasm, ...
Function diacylglycerol binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (153)    Tissues (22)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 153
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(11)
Other database
links
VEGA Gene ModelOTTMUSG00000044794 (Evidence)
Ensembl Gene ModelENSMUSG00000062151 (Evidence)
Entrez Gene208898 (Evidence)
UniGene41035
DFCITC1593520, TC1646721, TC1619504
DoTSDT.487717, DT.40147916, DT.101306399, DT.91562334
NIA Mouse Gene IndexU031090, U031089
Consensus CDS ProjectCCDS40690.1
International Mouse Knockout Project StatusUnc13c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044794 VEGA Gene Model | MGI Sequence Detail 489545 C57BL/6J ±  kb
transcript OTTMUST00000117738 VEGA | MGI Sequence Detail 8796 Not Applicable 
polypeptide OTTMUSP00000065782 VEGA | MGI Sequence Detail 2210 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(3270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR010439 Calcium-dependent secretion activator
InterPro IPR014772 Mammalian uncoordinated homology 13, domain 2
InterPro IPR019558 Mammalian uncoordinated homology 13, subgroup, domain 2
InterPro IPR014770 Munc13 homology 1
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR027087 Protein Unc-13 homologue C
InterPro IPR027080 Uncoordinated protein 13 (Unc-13)
Protein Ontology PR:000017088 protein unc-13 homolog C
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:197134 Chen Z, et al., The Munc13 Proteins Differentially Regulate Readily Releasable Pool Dynamics and Calcium-Dependent Recovery at a Central Synapse. J Neurosci. 2013 May 8;33(19):8336-8351
All references(42)
Other
accession IDs
MGI:1196392, MGI:1917504, MGI:2143201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory