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Unc13c Gene Detail
Summary
  • Symbol
    Unc13c
  • Name
    unc-13 homolog C
  • Synonyms
    1500037O19Rik, D9Ertd414e, MGC:40770, Munc13-3, Unc13h3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149021
    NCBI Gene: 208898
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:73479422-73968966 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 40.80 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3505 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149021
protein coding gene Chr9:73479422-74008154 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035029
protein coding gene Chr9:73710809-74213491 (-)
A/J MGP_AJ_G0035010
protein coding gene Chr9:71145517-71624167 (-)
AKR/J MGP_AKRJ_G0034939
protein coding gene Chr9:72835160-73334361 (-)
BALB/cJ MGP_BALBcJ_G0035002
protein coding gene Chr9:70830096-71304288 (-)
C3H/HeJ MGP_C3HHeJ_G0034711
protein coding gene Chr9:73322734-73803287 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035521
protein coding gene Chr9:75636903-76171243 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032432
protein coding gene Chr9:70565916-71028913 (-)
CAST/EiJ MGP_CASTEiJ_G0034033
protein coding gene Chr9:73647017-74137480 (-)
CBA/J MGP_CBAJ_G0034684
protein coding gene Chr9:78260299-78793896 (-)
DBA/2J MGP_DBA2J_G0034843
protein coding gene Chr9:70830803-71307090 (-)
FVB/NJ MGP_FVBNJ_G0034785
protein coding gene Chr9:70154628-70629755 (-)
LP/J MGP_LPJ_G0034924
protein coding gene Chr9:73939429-74446869 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034826
protein coding gene Chr9:79372609-79931893 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035543
protein coding gene Chr9:72988405-73491638 (-)
PWK/PhJ MGP_PWKPhJ_G0033737
protein coding gene Chr9:71108900-71590191 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033570
protein coding gene Chr9:73248324-73738294 (-)
WSB/EiJ MGP_WSBEiJ_G0034145
protein coding gene Chr9:72898517-73409104 (-)



Homology
more
  • Human Ortholog
    UNC13C, unc-13 homolog C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    UNC13C, unc-13 homolog C
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 440279
    neXtProt AC: NX_Q8NB66
    UniProt: Q8NB66

  • Chr Location
    15q21.3; chr15:53837573-54628608 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice demonstrate an impaired ability to learn complex motor tasks, putatively due to an observed increase in paired-pulse facilitation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062151 Ensembl Gene Model | MGI Sequence Detail 489545 C57BL/6J ±  kb
    transcript ENSMUST00000184666 Ensembl | MGI Sequence Detail 8796 Not Applicable  
    polypeptide ENSMUSP00000139027 Ensembl | MGI Sequence Detail 2210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 37
      Primer pair 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1196392, MGI:1917504, MGI:2143201
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:258680 Nicod J, et al., Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nat Genet. 2016 Aug;48(8):912-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory