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Dock2 Gene Detail
Summary
  • Symbol
    Dock2
  • Name
    dedicator of cyto-kinesis 2
  • Synonyms
    CED-5, Hch, MBC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149010
    NCBI Gene: 94176
  • Gene Overview
    MyGene.info: DOCK2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:34226815-34783892 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      557078 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 19.68 cM, cytoband A5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DOCK2, dedicator of cytokinesis 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DOCK2, dedicator of cytokinesis 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD40
  • Links
    NCBI Gene ID: 1794
    neXtProt AC: NX_Q92608
    UniProt: Q92608

  • Chr Location
    5q35.1; chr5:169637247-170083382 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 11 alleles in 12 genetic backgrounds
    45 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005408 VEGA Gene Model | MGI Sequence Detail 557078 C57BL/6J ±  kb
    transcript OTTMUST00000012054 VEGA | MGI Sequence Detail 6409 Not Applicable  
    polypeptide OTTMUSP00000005587 VEGA | MGI Sequence Detail 1828 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2373 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144253, MGI:2144499
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 47
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:250891 Ackerknecht M, et al., Antigen Availability and DOCK2-Driven Motility Govern CD4(+) T Cell Interactions with Dendritic Cells In Vivo. J Immunol. 2017 Jul 15;199(2):520-530

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory