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Dock2 Gene Detail
Summary
  • Symbol
    Dock2
  • Name
    dedicator of cyto-kinesis 2
  • Synonyms
    CED-5, Hch, MBC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149010
    NCBI Gene: 94176
  • Gene Overview
    MyGene.info: DOCK2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:34226815-34783892 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 19.68 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2373 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149010
protein coding gene Chr11:34226815-34783909 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018151
protein coding gene Chr11:32558581-33136401 (-)
A/J MGP_AJ_G0018124
protein coding gene Chr11:31335200-31898672 (-)
AKR/J MGP_AKRJ_G0018088
protein coding gene Chr11:32298849-32860281 (-)
BALB/cJ MGP_BALBcJ_G0018093
protein coding gene Chr11:31507600-32067248 (-)
C3H/HeJ MGP_C3HHeJ_G0017906
protein coding gene Chr11:32250716-32817715 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018547
protein coding gene Chr11:33598540-34172709 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016202
protein coding gene Chr11:29822525-30381290 (-)
CAST/EiJ MGP_CASTEiJ_G0017470
protein coding gene Chr11:32362196-32809626 (-)
CBA/J MGP_CBAJ_G0017879
protein coding gene Chr11:35263855-35862099 (-)
DBA/2J MGP_DBA2J_G0017989
protein coding gene Chr11:31095222-31652369 (-)
FVB/NJ MGP_FVBNJ_G0017983
protein coding gene Chr11:30926477-31486850 (-)
LP/J MGP_LPJ_G0018061
protein coding gene Chr11:32825491-33388233 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018007
protein coding gene Chr11:36158113-36603304 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018586
protein coding gene Chr11:32456733-32908063 (-)
PWK/PhJ MGP_PWKPhJ_G0017251
protein coding gene Chr11:31287718-31728238 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017043
protein coding gene Chr11:32192858-32664057 (-)
WSB/EiJ MGP_WSBEiJ_G0017519
protein coding gene Chr11:32094722-32662324 (-)



Homology
more
  • Human Ortholog
    DOCK2, dedicator of cytokinesis 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DOCK2, dedicator of cytokinesis 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD40
  • Links
    NCBI Gene ID: 1794
    neXtProt AC: NX_Q92608
    UniProt: Q92608

  • Chr Location
    5q35.1; chr5:169637247-170083382 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 11 alleles in 12 genetic backgrounds
    45 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020143 Ensembl Gene Model | MGI Sequence Detail 557078 C57BL/6J ±  kb
    transcript ENSMUST00000093193 Ensembl | MGI Sequence Detail 6409 Not Applicable  
    polypeptide ENSMUSP00000090884 Ensembl | MGI Sequence Detail 1828 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144253, MGI:2144499
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 49
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264323 Wong SY, et al., B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains. J Immunol. 2018 Sep 1;201(5):1442-1451

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory