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Dock2 Gene Detail
Summary
  • Symbol
    Dock2
  • Name
    dedicator of cyto-kinesis 2
  • Synonyms
    CED-5, Hch, MBC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149010
    NCBI Gene: 94176
  • Gene Overview
    MyGene.info: DOCK2
Location & Maps
more
  • Sequence Map
    Chr11:34226815-34783892 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      557078 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 19.68 cM, cytoband A5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DOCK2, dedicator of cytokinesis 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DOCK2, dedicator of cytokinesis 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD40
  • Links
    NCBI Gene ID: 1794
    neXtProt AC: NX_Q92608

  • Chr Location
    5q35.1; chr5:169637247-170083382 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DOCK2 associations

Human Disease Mouse Models
       Immunodeficiency 40; IMD40   OMIM: 616433
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 10 alleles in 11 genetic backgrounds
    13 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (ENU)
    9
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Dock2
  • Incidental Mutations
Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005408 VEGA Gene Model | MGI Sequence Detail 557078 C57BL/6J ±  kb
transcript OTTMUST00000012054 VEGA | MGI Sequence Detail 6409 Not Applicable  
polypeptide OTTMUSP00000005587 VEGA | MGI Sequence Detail 1828 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2373 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 6
Other
Accession IDs
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MGI:2144253, MGI:2144499
References
more
  • Summaries
    All 64
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 44
  • Earliest
    J:71005 Fukui Y, et al., Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature. 2001 Aug 23;412(6849):826-31
  • Latest
    J:231437 Mahajan VS, et al., Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain. Cell Rep. 2016 May 18;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory