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Clic1 Gene Detail
Summary
  • Symbol
    Clic1
  • Name
    chloride intracellular channel 1
  • Synonyms
    Clcp, G6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148924
    NCBI Gene: 114584
  • Gene Overview
    MyGene.info: CLIC1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35050243-35058719 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148924
protein coding gene Chr17:35049966-35058749 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023609
protein coding gene Chr17:35186313-35198553 (+)
A/J MGP_AJ_G0023569
protein coding gene Chr17:34023991-34032524 (+)
AKR/J MGP_AKRJ_G0023537
protein coding gene Chr17:34494980-34507109 (+)
BALB/cJ MGP_BALBcJ_G0023575
protein coding gene Chr17:34155391-34168841 (+)
C3H/HeJ MGP_C3HHeJ_G0023336
protein coding gene Chr17:34890506-34899911 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024014
protein coding gene Chr17:36527314-36535511 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021495
protein coding gene Chr17:31790594-31799680 (+)
CAST/EiJ MGP_CASTEiJ_G0022833
protein coding gene Chr17:34893888-34902547 (+)
CBA/J MGP_CBAJ_G0023314
protein coding gene Chr17:38033902-38042546 (+)
DBA/2J MGP_DBA2J_G0023442
protein coding gene Chr17:33344238-33352817 (+)
FVB/NJ MGP_FVBNJ_G0023409
protein coding gene Chr17:33180775-33189334 (+)
LP/J MGP_LPJ_G0023519
protein coding gene Chr17:35512747-35524236 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023431
protein coding gene Chr17:36968200-36978235 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024059
protein coding gene Chr17:34717640-34726310 (+)
PWK/PhJ MGP_PWKPhJ_G0022580
protein coding gene Chr17:32177144-32186230 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022400
protein coding gene Chr17:32728139-32736519 (+)
WSB/EiJ MGP_WSBEiJ_G0022896
protein coding gene Chr17:34834429-34845332 (+)



Homology
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  • Human Ortholog
    CLIC1, chloride intracellular channel 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CLIC1, chloride intracellular channel 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CL1C1, G6, NCC27
  • Links
    NCBI Gene ID: 1192
    neXtProt AC: NX_O00299
    UniProt: O00299

  • Chr Location
    6p21.33; chr6:31730581-31737318 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice Homozygous for disruptions in this gene display abnormal platelet number, activation and aggregation and prolonged bleeding time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 114584 NCBI Gene Model | MGI Sequence Detail 8477 C57BL/6J ±  kb
transcript NM_033444 RefSeq | MGI Sequence Detail 1159 C57BL/6  
polypeptide Q9Z1Q5 UniProt | EBI | MGI Sequence Detail 241 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005574 chloride intracellular channel protein 1
  • InterPro Domains
    IPR030259 Chloride intracellular channel protein 1
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR004045 Glutathione S-transferase, N-terminal
    IPR002946 Intracellular chloride channel
    IPR036249 Thioredoxin-like superfamily
Molecular
Reagents
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  • All nucleic 270
    Genomic 1
    cDNA 268
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:63110 Martin AM, et al., Immunol Today. 2000;21(7):Centerfold
  • Latest
    J:250729 Tang T, et al., CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017 Aug 04;8(1):202

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory