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Ehmt2 Gene Detail
Summary
  • Symbol
    Ehmt2
  • Name
    euchromatic histone lysine N-methyltransferase 2
  • Synonyms
    Bat8, D17Ertd710e, G9a, KMT1C, NG36
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148922
    NCBI Gene: 110147
  • Gene Overview
    MyGene.info: EHMT2
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34898469-34914052 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.45 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148922
protein coding gene Chr17:34898466-34914052 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023597
protein coding gene Chr17:35016221-35037519 (+)
A/J MGP_AJ_G0023559
protein coding gene Chr17:33872158-33888254 (+)
AKR/J MGP_AKRJ_G0023525
protein coding gene Chr17:34332474-34350602 (+)
BALB/cJ MGP_BALBcJ_G0023564
protein coding gene Chr17:33998881-34016054 (+)
C3H/HeJ MGP_C3HHeJ_G0023324
protein coding gene Chr17:34729341-34746428 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024004
protein coding gene Chr17:36353087-36370932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021483
protein coding gene Chr17:31634656-31652997 (+)
CAST/EiJ MGP_CASTEiJ_G0022822
protein coding gene Chr17:34724372-34742550 (+)
CBA/J MGP_CBAJ_G0023302
protein coding gene Chr17:37860320-37876856 (+)
DBA/2J MGP_DBA2J_G0023430
protein coding gene Chr17:33185594-33203548 (+)
FVB/NJ MGP_FVBNJ_G0023397
protein coding gene Chr17:33017128-33034544 (+)
LP/J MGP_LPJ_G0023507
protein coding gene Chr17:35337476-35365725 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023420
protein coding gene Chr17:36798998-36815515 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024046
protein coding gene Chr17:34559069-34575439 (+)
PWK/PhJ MGP_PWKPhJ_G0022571
protein coding gene Chr17:32013420-32030324 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022388
protein coding gene Chr17:32562307-32580061 (+)
WSB/EiJ MGP_WSBEiJ_G0022884
protein coding gene Chr17:34668864-34690038 (+)



Homology
more
  • Human Ortholog
    EHMT2, euchromatic histone lysine methyltransferase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EHMT2, euchromatic histone lysine methyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BAT8, C6orf30, G9A, GAT8, KMT1C, NG36
  • Links
    NCBI Gene ID: 10919
    neXtProt AC: NX_Q96KQ7
    UniProt: Q96KQ7

  • Chr Location
    6p21.33; chr6:31879759-31897707 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 8 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality around E9.5-E12.5. Mutant embryos are developmentally delayed. Conditional deletion in germ cells results in infertility and arrest of meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013787 Ensembl Gene Model | MGI Sequence Detail 15584 C57BL/6J ±  kb
    transcript ENSMUST00000013931 Ensembl | MGI Sequence Detail 4026 Not Applicable  
    polypeptide ENSMUSP00000013931 Ensembl | MGI Sequence Detail 1263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 293
      Genomic 6
      cDNA 283
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1513, MGI:1289297, MGI:1925626, MGI:88132
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 27
      Gene Ontology 26
      Phenotypes 36
    • Earliest
      J:15971 Gasser DL, et al., P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci [see comments]. Immunogenetics. 1994;39(1):48-55
    • Latest
      J:263725 Iacono G, et al., Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome. Nucleic Acids Res. 2018 Jun 1;46(10):4950-4965

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory