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Ehmt2
Gene Detail
 Symbol
Name
ID
Ehmt2
euchromatic histone lysine N-methyltransferase 2
MGI:2148922
Synonyms Bat8, D17Ertd710e, G9a, KMT1C, NG36
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:34898469-34914052 bp, + strand
From VEGA annotation of GRCm38

  15584 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48460  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone H3-K9 methyltransferase, Ehmt2 type
Gene Tree: Ehmt2

Human
homologs
Human Homolog EHMT2, euchromatic histone-lysine N-methyltransferase 2
NCBI Gene ID 10919
neXtProt AC  NX_Q96KQ7
Human Synonyms  BAT8, C6orf30, G9A, GAT8, KMT1C, NG36
Human Chr (Location)  6p21.31; chr6:31879759-31897707 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(15) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality around E9.5-E12.5. Mutant embryos are developmentally delayed. Conditional deletion in germ cells results in infertility and arrest of meiosis.
 
Interactions
Ehmt2 interacts with 190 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (104 annotations)
Process chromatin modification, DNA methylation, ...
Component chromosome, nucleus
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (150)    Tissues (115)    Images (17)
Theiler Stages: 2, 3, 11, 15, 17, 19, 20, 22, 24, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 102
Western blot 2
RT-PCR 38
cDNA source data(283)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(291) Genomic(5) cDNA(283) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016295 (Evidence)
Ensembl Gene ModelENSMUSG00000013787 (Evidence)
Entrez Gene110147 (Evidence)
UniGene35345
DFCITC1597397, TC1598033, TC1601175, TC1720812
DoTSDT.101738405, DT.495139, DT.94249617, DT.94380648, DT.97375111, DT.99861592
NIA Mouse Gene IndexU017874
EC2.1.1.-, 2.1.1.43
Consensus CDS ProjectCCDS28666.1, CCDS28667.1, CCDS70797.1, CCDS70798.1
International Mouse Knockout Project StatusEhmt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016295 VEGA Gene Model | MGI Sequence Detail 15584 C57BL/6J ±  kb
transcript OTTMUST00000039149 VEGA | MGI Sequence Detail 4026 Not Applicable 
polypeptide OTTMUSP00000017486 VEGA | MGI Sequence Detail 1263 Not Applicable 

For the selected sequences
All sequences(112) RefSeq(24) UniProt(7)
Polymorphisms SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR003616 Post-SET domain
InterPro IPR007728 Pre-SET domain
InterPro IPR003606 Pre-SET zinc-binding sub-group
InterPro IPR001214 SET domain
Protein Ontology PR:000006949 histone-lysine N-methyltransferase, H3 lysine-9 specific 3
References (Earliest) J:15971 Gasser DL, et al., P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci [see comments]. Immunogenetics. 1994;39(1):48-55
(Latest) J:212015 Maze I, et al., G9a influences neuronal subtype specification in striatum. Nat Neurosci. 2014 Apr;17(4):533-9
All references(96)
Other
accession IDs
MGD-MRK-1513, MGI:1289297, MGI:1925626, MGI:88132

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory