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Ehmt2 Gene Detail
Summary
  • Symbol
    Ehmt2
  • Name
    euchromatic histone lysine N-methyltransferase 2
  • Synonyms
    Bat8, D17Ertd710e, G9a, KMT1C, NG36
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148922
    NCBI Gene: 110147
  • Gene Overview
    MyGene.info: EHMT2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:34898469-34914052 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15584 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.45 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    EHMT2, euchromatic histone lysine methyltransferase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EHMT2, euchromatic histone lysine methyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BAT8, C6orf30, G9A, GAT8, KMT1C, NG36
  • Links
    NCBI Gene ID: 10919
    neXtProt AC: NX_Q96KQ7
    UniProt: Q96KQ7

  • Chr Location
    6p21.33; chr6:31879759-31897707 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 8 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality around E9.5-E12.5. Mutant embryos are developmentally delayed. Conditional deletion in germ cells results in infertility and arrest of meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016295 VEGA Gene Model | MGI Sequence Detail 15584 C57BL/6J ±  kb
    transcript OTTMUST00000039149 VEGA | MGI Sequence Detail 4026 Not Applicable  
    polypeptide OTTMUSP00000017486 VEGA | MGI Sequence Detail 1263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 291
      Genomic 5
      cDNA 283
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1513, MGI:1289297, MGI:1925626, MGI:88132
    References
    more
    • Summaries
      All 127
      Developmental Gene Expression 26
      Gene Ontology 26
      Phenotypes 34
    • Earliest
      J:15971 Gasser DL, et al., P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci [see comments]. Immunogenetics. 1994;39(1):48-55
    • Latest
      J:259618 Hatazawa Y, et al., Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration. FASEB J. 2018 Mar;32(3):1452-1467

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory