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Dok4 Gene Detail
Summary
  • Symbol
    Dok4
  • Name
    docking protein 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148865
    NCBI Gene: 114255
  • Gene Overview
    MyGene.info: DOK4
Location & Maps
more
  • Sequence Map
    Chr8:94863828-94876312 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12485 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.93 cM, cytoband C5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DOK4, docking protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DOK4, docking protein 4
    Orthology source: HomoloGene
  • Synonyms
    IRS5, IRS-5
  • Links
    NCBI Gene ID: 55715
    neXtProt AC: NX_Q8TEW6

  • Chr Location
    16q21; chr16:57471958-57486473 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10009
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DOK4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 114255 NCBI Gene Model | MGI Sequence Detail 12485 C57BL/6J ±  kb
transcript NM_053246 RefSeq | MGI Sequence Detail 2604 C57BL/6  
polypeptide Q99KE3 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    29 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 70
    cDNA 69
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 24
    Developmental Gene Expression 5
    Gene Ontology 2
  • Earliest
    J:70544 Grimm J, et al., Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol. 2001 Jul 23;154(2):345-54
  • Latest
    J:206879 Huang T, et al., BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014 Feb 15;386(2):308-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory