About   Help   FAQ
Dok4 Gene Detail
Summary
  • Symbol
    Dok4
  • Name
    docking protein 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148865
    NCBI Gene: 114255
  • Gene Overview
    MyGene.info: DOK4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94863828-94876312 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.93 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148865
protein coding gene Chr8:94863828-94876330 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033973
protein coding gene Chr8:96306293-96317185 (-)
A/J MGP_AJ_G0033956
protein coding gene Chr8:92552283-92564783 (-)
AKR/J MGP_AKRJ_G0033882
protein coding gene Chr8:95075473-95087977 (-)
BALB/cJ MGP_BALBcJ_G0033948
protein coding gene Chr8:92633755-92646297 (-)
C3H/HeJ MGP_C3HHeJ_G0033658
protein coding gene Chr8:95787862-95801723 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034469
protein coding gene Chr8:99816309-99828802 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031410
protein coding gene Chr8:86354773-86367280 (-)
CAST/EiJ MGP_CASTEiJ_G0032990
protein coding gene Chr8:95391764-95404255 (-)
CBA/J MGP_CBAJ_G0033634
protein coding gene Chr8:103110571-103123112 (-)
DBA/2J MGP_DBA2J_G0033788
protein coding gene Chr8:92031670-92044588 (-)
FVB/NJ MGP_FVBNJ_G0033735
protein coding gene Chr8:90982241-90994712 (-)
LP/J MGP_LPJ_G0033880
protein coding gene Chr8:96451220-96462573 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033777
protein coding gene Chr8:105399610-105412101 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034487
protein coding gene Chr8:95239814-95253668 (-)
PWK/PhJ MGP_PWKPhJ_G0032692
protein coding gene Chr8:91399379-91411869 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032529
protein coding gene Chr8:94084084-94096553 (-)
WSB/EiJ MGP_WSBEiJ_G0033102
protein coding gene Chr8:95774677-95787169 (-)



Homology
more
  • Human Ortholog
    DOK4, docking protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DOK4, docking protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRS5, IRS-5
  • Links
    NCBI Gene ID: 55715
    neXtProt AC: NX_Q8TEW6
    UniProt: Q8TEW6

  • Chr Location
    16q21; chr16:57471958-57486473 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10009
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DOK4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 114255 NCBI Gene Model | MGI Sequence Detail 12485 C57BL/6J ±  kb
transcript NM_053246 RefSeq | MGI Sequence Detail 2604 C57BL/6  
polypeptide Q99KE3 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 71
    cDNA 70
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 24
    Developmental Gene Expression 5
    Gene Ontology 1
  • Earliest
    J:70544 Grimm J, et al., Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol. 2001 Jul 23;154(2):345-54
  • Latest
    J:246700 Hooker E, et al., Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4. Biochem J. 2017 Apr 19;474(9):1509-1528

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory