About   Help   FAQ
Npnt
Gene Detail
 Symbol
Name
ID
Npnt
nephronectin
MGI:2148811
Synonyms 1110009H02Rik, POEM
Feature Type protein coding gene
Genetic Map
Chromosome 3
61.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:132881745-132950291 bp, - strand
From VEGA annotation of GRCm38

  68547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14138  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Npnt

Human
homologs
Human Homolog NPNT, nephronectin
NCBI Gene ID 255743
neXtProt AC  NX_Q6UXI9
Human Synonyms  EGFL6L, POEM
Human Chr (Location)  4q24; chr4:105895432-105971671 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele frequently exhibit kidney agenesis or hypoplasia attributed to a delay in the invasion of the metanephric mesenchyme by the ureteric bud at an early stage of kidney development.
 
Interactions
Npnt interacts with 336 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process branching involved in ureteric bud morphogenesis, cell adhesion, ...
Component basement membrane, extracellular matrix, ...
Function calcium ion binding, integrin binding
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (381)    Tissues (106)    Images (37)
Theiler Stages: 10, 12, 15, 18, 20, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 355
Northern blot 17
RT-PCR 2
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(18) Primer pair(3) Other(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000026534 (Evidence)
Ensembl Gene ModelENSMUSG00000040998 (Evidence)
Entrez Gene114249 (Evidence)
DFCITC1579536, TC1592276, TC1632461, TC1694348
DoTSDT.101379662, DT.490665, DT.532521, DT.91304199, DT.94149854
NIA Mouse Gene IndexU024666
Consensus CDS ProjectCCDS17845.1, CCDS17846.1, CCDS71321.1, CCDS71322.1, CCDS71323.1
International Mouse Knockout Project StatusNpnt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026534 VEGA Gene Model | MGI Sequence Detail 68547 C57BL/6J ±  kb
transcript OTTMUST00000065653 VEGA | MGI Sequence Detail 1830 Not Applicable 
polypeptide OTTMUSP00000032749 VEGA | MGI Sequence Detail 609 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(446 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026823 Complement Clr-like EGF domain
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000998 MAM domain
Protein Ontology PR:000011373 nephronectin
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202352 Boualia SK, et al., A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis. Dev Biol. 2013 Oct 15;382(2):555-66
All references(56)
Other
accession IDs
MGI:1915250, MGI:2139604, MGI:2139662

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory