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Npnt Gene Detail
Summary
  • Symbol
    Npnt
  • Name
    nephronectin
  • Synonyms
    1110009H02Rik, POEM
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148811
    NCBI Gene: 114249
Location & Maps
more
  • Sequence Map
    Chr3:132881745-132950291 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      68547 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 61.52 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NPNT, nephronectin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NPNT, nephronectin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EGFL6L, POEM
  • Links
    NCBI Gene ID: 255743
    neXtProt AC: NX_Q6UXI9

  • Chr Location
    4q24; chr4:105894526-105971671 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 14138
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NPNT
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Npnt
  • Incidental Mutations
Mice homozygous for a null allele frequently exhibit kidney agenesis or hypoplasia attributed to a delay in the invasion of the metanephric mesenchyme by the ureteric bud at an early stage of kidney development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026534 VEGA Gene Model | MGI Sequence Detail 68547 C57BL/6J ±  kb
transcript OTTMUST00000065653 VEGA | MGI Sequence Detail 1830 Not Applicable  
polypeptide OTTMUSP00000032749 VEGA | MGI Sequence Detail 609 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    445 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 18
    Primer pair 3
    Other 2

    Microarray probesets 8
Other
Accession IDs
less
MGI:1915250, MGI:2139604, MGI:2139662
References
more
  • Summaries
    All 52
    Developmental Gene Expression 21
    Gene Ontology 11
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:202352 Boualia SK, et al., A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis. Dev Biol. 2013 Oct 15;382(2):555-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory