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Npnt
Gene Detail
Symbol

Name
ID
Npnt
nephronectin
MGI:2148811
Synonyms
1110009H02Rik, POEM
Feature Type
protein coding gene
Genetic Map
Chromosome 3
61.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:132881745-132950291 bp, - strand
From VEGA annotation of GRCm38

  68547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14138  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NPNT
Gene Tree: Npnt

Human
homologs
NPNT, nephronectin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 255743
neXtProt AC: NX_Q6UXI9

Human Synonyms: EGFL6L, POEM

Human Chr (Location): 4q24; chr4:105894526-105971671 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele frequently exhibit kidney agenesis or hypoplasia attributed to a delay in the invasion of the metanephric mesenchyme by the ureteric bud at an early stage of kidney development.
 
Interactions
Npnt interacts with 336 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process branching involved in ureteric bud morphogenesis, cell adhesion, ...
Component basement membrane, extracellular exosome, ...
Function calcium ion binding, integrin binding
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (381)    Tissues (106)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 355
Northern blot 17
RT-PCR 2
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase npnt ; ZFIN npnt    NEW 
Molecular
reagents
All nucleic(23) cDNA(18) Primer pair(3) Other(2)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000026534 (Evidence)
Ensembl Gene Model ENSMUSG00000040998 (Evidence)
Entrez Gene 114249 (Evidence)
DFCI TC1592276, TC1632461, TC1694348, TC1579536
DoTS DT.490665, DT.532521, DT.101379662, DT.94149854, DT.91304199
NIA Mouse Gene Index U024666
Consensus CDS Project CCDS17845.1, CCDS17846.1, CCDS71321.1, CCDS71322.1, CCDS71323.1
International Mouse Phenotyping Consortium Status Npnt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026534 VEGA Gene Model | MGI Sequence Detail 68547 C57BL/6J ±  kb
transcript OTTMUST00000065653 VEGA | MGI Sequence Detail 1830 Not Applicable 
polypeptide OTTMUSP00000032749 VEGA | MGI Sequence Detail 609 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(446 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026823 Complement Clr-like EGF domain
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000998 MAM domain
Protein Ontology PR:000011373 nephronectin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202352 Boualia SK, et al., A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis. Dev Biol. 2013 Oct 15;382(2):555-66
All references(55)
Other
accession IDs
MGI:1915250, MGI:2139604, MGI:2139662

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory