Sec16b MGI Mouse Gene Detail - MGI:2148802 - SEC16 homolog B (S. cerevisiae)

Sec16b Gene Detail

Symbol

Sec16b
Name

SEC16 homolog B (S. cerevisiae)
Synonyms

Lztr2, Rgpr, Rgpr-p117

Feature Type

protein coding gene
IDs

MGI:2148802
NCBI Gene: 89867
Gene Overview

MyGene.info: SEC16B

Sequence Map

Chr1:157506728-157568425 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

61698 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 68.00 cM, cytoband H1
Mapping Data

1 experiment

Human Ortholog

SEC16B, SEC16 homolog B, endoplasmic reticulum export factor

Vertebrate Orthologs

9

Human Ortholog

SEC16B, SEC16 homolog B, endoplasmic reticulum export factor
Orthology source: HomoloGene, HGNC
Synonyms

LZTR2, PGPR-p117, RGPR, SEC16S
Links

HGNC:30301

NCBI Gene ID: 89866

neXtProt AC: NX_Q96JE7

UniProt: Q96JE7
Chr Location

1q25.2; chr1:177929107-177969915 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 13227
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SEC16B
Gene Tree

Sec16b

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

2
Targeted

2
Genomic Mutations

2 involving Sec16b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available

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All GO Annotations

14
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

176
Tissues

18
cDNA Data

25
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sec16b

ZFIN sec16b

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Sec16b interacts with 223 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

46
RefSeq

15
UniProt

2
CCDS

CCDS15400.1
UniGene

87114

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022599	VEGA Gene Model \| MGI Sequence Detail	61698	C57BL/6J	± kb
transcript	OTTMUST00000054130	VEGA \| MGI Sequence Detail	4661	Not Applicable
polypeptide	OTTMUSP00000025792	VEGA \| MGI Sequence Detail	1051	Not Applicable

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SNPs within 2kb

739 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000014582 protein transport protein Sec16B

(term hierarchy)
InterPro Domains

IPR024298 Ancestral coatomer element 1, Sec16/Sec31

IPR024880 COPII coat assembly protein, Sec16

IPR024340 Sec16, central conserved domain

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All nucleic 25

cDNA 25

Microarray probesets 2

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 5
Earliest

J:71988 Misawa H, et al., Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver. Int J Mol Med. 2001 Nov;8(5):513-20
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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