Afg1l MGI Mouse Gene Detail - MGI:2148801

Symbol

Afg1l
Name

AFG1 like ATPase
Synonyms

Lace1

Feature Type

protein coding gene
IDs

MGI:2148801
NCBI Gene: 215951
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:42188581-42354561 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.88 cM
Mapping Data

4 experiments

SNPs within 2kb

752 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2148801	protein coding gene	Chr10:42188577-42354561 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017184	protein coding gene	Chr10:41009521-41191358 (-)
A/J	MGP_AJ_G0017161	protein coding gene	Chr10:39856353-40032698 (-)
AKR/J	MGP_AKRJ_G0017121	protein coding gene	Chr10:40466672-40638471 (-)
BALB/cJ	MGP_BALBcJ_G0017123	protein coding gene	Chr10:39924578-40095531 (-)
C3H/HeJ	MGP_C3HHeJ_G0016944	protein coding gene	Chr10:40806212-40986970 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017582	protein coding gene	Chr10:42250985-42432251 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015278	protein coding gene	Chr10:37734008-37892519 (-)
CAST/EiJ	MGP_CASTEiJ_G0016523	protein coding gene	Chr10:40996489-41172076 (-)
CBA/J	MGP_CBAJ_G0016918	protein coding gene	Chr10:44189196-44378778 (-)
DBA/2J	MGP_DBA2J_G0017023	protein coding gene	Chr10:39349863-39517213 (-)
FVB/NJ	MGP_FVBNJ_G0017018	protein coding gene	Chr10:38847342-39011884 (-)
LP/J	MGP_LPJ_G0017100	protein coding gene	Chr10:41013919-41179645 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017048	protein coding gene	Chr10:44948525-45135897 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017619	protein coding gene	Chr10:40435352-40618201 (-)
PWK/PhJ	MGP_PWKPhJ_G0016303	protein coding gene	Chr10:39228402-39389743 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016087	protein coding gene	Chr10:40256686-40435149 (-)
WSB/EiJ	MGP_WSBEiJ_G0016586	protein coding gene	Chr10:40748457-40920041 (-)

Human Ortholog

AFG1L, AFG1 like ATPase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AFG1L, AFG1 like ATPase
Synonyms

AFG1, c222389, LACE1
Links

HGNC:16411

NCBI Gene ID: 246269

neXtProt AC: NX_Q8WV93

UniProt: Q8WV93
Chr Location

6q21; chr6:108294991-108526796 (+) GRCh38

MGI Vertebrate Homology

Afg1l stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: AFG1L
Gene Tree

Afg1l

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

11
Radiation induced

1
Genomic Mutations

2 involving Afg1l
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

21
cDNA Data

26
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase afg1l

ZFIN afg1lb

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All Sequences

56
RefSeq

12
UniProt

4
CCDS

CCDS23811.1

Ensembl

ENSMUSG00000038302 (Evidence)
NCBI Gene

215951

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038302	Ensembl Gene Model \| MGI Sequence Detail	165981	C57BL/6J	± kb
transcript	ENSMUST00000041024	Ensembl \| MGI Sequence Detail	2513	Not Applicable
polypeptide	ENSMUSP00000036149	Ensembl \| MGI Sequence Detail	480	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009644 AFG1-like ATPase

(term hierarchy)
EC

3.6.-.-
InterPro Domains

IPR005654 ATPase, AFG1-like

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 28

Genomic 1

cDNA 26

Primer pair 1

Microarray probesets 4

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Afg1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97444	Chr10:42354484-42354499 (-)	69 bp
Tssr97443	Chr10:42354395-42354439 (-)	144 bp
Tssr97442	Chr10:42351097-42351115 (-)	3,455 bp
Tssr97441	Chr10:42351066-42351081 (-)	3,487 bp
Tssr97440	Chr10:42264323-42264327 (-)	90,236 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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