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Tssk6
Gene Detail
Symbol

Name
ID
Tssk6
testis-specific serine kinase 6
MGI:2148775
Synonyms
Sstk
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.05 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:69902215-69903518 bp, + strand
From NCBI annotation of GRCm38

  1304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49068  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: testis-specific serine/threonine-protein kinase
Gene Tree: Tssk6

Human
homologs
Human Homolog TSSK6, testis-specific serine kinase 6
NCBI Gene ID 83983
neXtProt AC  NX_Q9BXA6
Human Synonyms  CT72, SSTK, TSSK4
Human Chr (Location)  19p13.11; chr19:19514219-19515660 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from APF )
 
Homozygous null males are infertile and exhibit decreased sperm numbers and sperm motility, abnormal sperm head morphology and reduced DNA compaction in spermatozoa.
 
Interactions
Tssk6 interacts with 28 markers (Mir25, Mir32, Mir92-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(12)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000047654 (Evidence)
Entrez Gene83984 (Evidence)
UniGene432504
DFCITC1584744
NIA Mouse Gene IndexU009414
EC2.7.11.1
Consensus CDS ProjectCCDS22354.1
International Mouse Knockout Project StatusTssk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 83984 NCBI Gene Model | MGI Sequence Detail 1304 C57BL/6J ±  kb
transcript NM_032004 RefSeq | MGI Sequence Detail 1327 C57BL/6 
polypeptide Q925K9 UniProt | EBI | MGI Sequence Detail 273 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000016774 testis-specific serine/threonine-protein kinase 6
Graphical View of Protein Domain Structure
References
(Earliest) J:98891 Spiridonov NA, et al., Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. Mol Cell Biol. 2005 May;25(10):4250-61
(Latest) J:175334 Li Y, et al., Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. Mol Hum Reprod. 2011 Jan;17(1):42-56
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory