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Tssk6 Gene Detail
Summary
  • Symbol
    Tssk6
  • Name
    testis-specific serine kinase 6
  • Synonyms
    Sstk
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148775
    NCBI Gene: 83984
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:69902184-69903518 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1335 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.05 cM, cytoband C1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TSSK6, testis specific serine kinase 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TSSK6, testis specific serine kinase 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CT72, FKSG82, SSTK, TSSK4
  • Links
    NCBI Gene ID: 83983
    neXtProt AC: NX_Q9BXA6
    UniProt: Q9BXA6

  • Chr Location
    19p13.11; chr19:19514219-19515660 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    1
  • Genomic Mutations
    1 involving Tssk6
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Homozygous null males are infertile and exhibit decreased sperm numbers and sperm motility, abnormal sperm head morphology and reduced DNA compaction in spermatozoa.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050077 VEGA Gene Model | MGI Sequence Detail 1335 C57BL/6J ±  kb
transcript OTTMUST00000127358 VEGA | MGI Sequence Detail 1335 Not Applicable  
polypeptide OTTMUSP00000068727 VEGA | MGI Sequence Detail 273 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    23 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:98891 Spiridonov NA, et al., Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. Mol Cell Biol. 2005 May;25(10):4250-61
  • Latest
    J:253146 Jha KN, et al., TSSK6 is required for gammaH2AX formation and the histone-to-protamine transition during spermiogenesis. J Cell Sci. 2017 May 15;130(10):1835-1844

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory