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Tssk6 Gene Detail
Summary
  • Symbol
    Tssk6
  • Name
    testis-specific serine kinase 6
  • Synonyms
    Sstk
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148775
    NCBI Gene: 83984
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:69902184-69903518 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.05 cM, cytoband C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148775
protein coding gene Chr8:69902184-69903518 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033683
protein coding gene Chr8:70131106-70132440 (+)
A/J MGP_AJ_G0033666
protein coding gene Chr8:67283548-67284882 (+)
AKR/J MGP_AKRJ_G0033591
protein coding gene Chr8:69189739-69191073 (+)
BALB/cJ MGP_BALBcJ_G0033662
protein coding gene Chr8:67509708-67511042 (+)
C3H/HeJ MGP_C3HHeJ_G0033372
protein coding gene Chr8:69850960-69852294 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034179
protein coding gene Chr8:72799290-72800624 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031123
protein coding gene Chr8:62107824-62109158 (+)
CAST/EiJ MGP_CASTEiJ_G0032697
protein coding gene Chr8:69315805-69317139 (+)
CBA/J MGP_CBAJ_G0033350
protein coding gene Chr8:75436981-75438315 (+)
DBA/2J MGP_DBA2J_G0033504
protein coding gene Chr8:67009941-67011275 (+)
FVB/NJ MGP_FVBNJ_G0033445
protein coding gene Chr8:66106592-66107926 (+)
LP/J MGP_LPJ_G0033591
protein coding gene Chr8:70181417-70182751 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033489
protein coding gene Chr8:78094454-78095788 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034197
protein coding gene Chr8:69372611-69373945 (+)
PWK/PhJ MGP_PWKPhJ_G0032405
protein coding gene Chr8:66294571-66295905 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032241
protein coding gene Chr8:68349348-68350682 (+)
WSB/EiJ MGP_WSBEiJ_G0032812
protein coding gene Chr8:69741651-69742985 (+)



Homology
more
  • Human Ortholog
    TSSK6, testis specific serine kinase 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TSSK6, testis specific serine kinase 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CT72, FKSG82, SSTK, TSSK4
  • Links
    NCBI Gene ID: 83983
    neXtProt AC: NX_Q9BXA6
    UniProt: Q9BXA6

  • Chr Location
    19p13.11; chr19:19514219-19515660 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    1
  • Genomic Mutations
    1 involving Tssk6
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Homozygous null males are infertile and exhibit decreased sperm numbers and sperm motility, abnormal sperm head morphology and reduced DNA compaction in spermatozoa.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 83984 NCBI Gene Model | MGI Sequence Detail 1335 C57BL/6J ±  kb
transcript NM_032004 RefSeq | MGI Sequence Detail 1358 C57BL/6  
polypeptide Q925K9 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:98891 Spiridonov NA, et al., Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. Mol Cell Biol. 2005 May;25(10):4250-61
  • Latest
    J:253146 Jha KN, et al., TSSK6 is required for gammaH2AX formation and the histone-to-protamine transition during spermiogenesis. J Cell Sci. 2017 May 15;130(10):1835-1844

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory