About   Help   FAQ
Ddx19b Gene Detail
Summary
  • Symbol
    Ddx19b
  • Name
    DEAD box helicase 19b
  • Synonyms
    2810457M08Rik, 4921519L13Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148251
    NCBI Gene: 234733
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111729820-111758383 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    736 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148251
 protein coding gene Chr8:111729818-111758383 (-)
129S1/SvImJ ENSMUSG00200013629
 protein coding gene Chr8:106034093-106062659 (-)
A/J ENSMUSG00195018111
 protein coding gene Chr8:106346704-106375271 (-)
AKR/J ENSMUSG00220015175
 protein coding gene Chr8:106489136-106517703 (-)
BALB/cJ ENSMUSG00180018713
 protein coding gene Chr8:106351187-106380077 (-)
C3H/HeJ ENSMUSG00175023832
 protein coding gene Chr8:106409019-106437590 (-)
C57BL/6NJ ENSMUSG00215035082
 protein coding gene Chr8:106011973-106040544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031568
 protein coding gene Chr8:102094269-102123947 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210029974
 protein coding gene Chr8:106336164-106364728 (-)
DBA/2J ENSMUSG00185017214
 protein coding gene Chr8:112445278-112473841 (-)
FVB/NJ ENSMUSG00205021806
 protein coding gene Chr8:105348635-105377202 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230033411
 protein coding gene Chr8:116125068-116153632 (-)
NOD/ShiLtJ ENSMUSG00190024127
 protein coding gene Chr8:106487155-106515720 (-)
NZO/HlLtJ ENSMUSG00225021707
 protein coding gene Chr8:119475750-119504313 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010039236
 protein coding gene Chr8:108344873-108367179 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    DDX19B, DEAD-box helicase 19B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX19B, DEAD-box helicase 19B
  • Synonyms
    DBP5, DDX19, RNAh
  • Links
    NCBI Gene ID: 11269
    UniProt: Q9UMR2

  • Chr Location
    16q22.1; chr16:70289663-70335305 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is embryonic lethal. Heterozygous KO leads to increased resistance to RNA virus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    617
  • Tissues
    4
  • cDNA Data
    79
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033658 Ensembl Gene Model | MGI Sequence Detail 28564 C57BL/6J ±  kb
    transcript ENSMUST00000065784 Ensembl | MGI Sequence Detail 3104 Not Applicable  
    polypeptide ENSMUSP00000066806 Ensembl | MGI Sequence Detail 494 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
      3.6.4.13
    • InterPro Domains
      IPR011545 DEAD/DEAH-box helicase domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR014014 RNA helicase, DEAD-box type, Q motif
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 80

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918149, MGI:2142782
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory