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Ddx19b Gene Detail
Summary
  • Symbol
    Ddx19b
  • Name
    DEAD box helicase 19b
  • Synonyms
    2810457M08Rik, 4921519L13Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148251
    NCBI Gene: 234733
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111729820-111758383 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    736 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148251
 protein coding gene Chr8:111729818-111758383 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034133
 protein coding gene Chr8:113712488-113751150 (-)
A/J MGP_AJ_G0034112
 protein coding gene Chr8:109115587-109145037 (-)
AKR/J MGP_AKRJ_G0034039
 protein coding gene Chr8:112307188-112336497 (-)
BALB/cJ MGP_BALBcJ_G0034106
 protein coding gene Chr8:109288455-109321187 (-)
C3H/HeJ MGP_C3HHeJ_G0033817
 protein coding gene Chr8:113023619-113057085 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034626
 protein coding gene Chr8:117708597-117741552 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031568
 protein coding gene Chr8:102094269-102123947 (-)
CAST/EiJ MGP_CASTEiJ_G0033144
 protein coding gene Chr8:112645249-112668680 (-)
CBA/J MGP_CBAJ_G0033791
 protein coding gene Chr8:121710966-121757516 (-)
DBA/2J MGP_DBA2J_G0033946
 protein coding gene Chr8:108402681-108434065 (-)
FVB/NJ MGP_FVBNJ_G0033890
 protein coding gene Chr8:107360985-107394055 (-)
LP/J MGP_LPJ_G0034036
 protein coding gene Chr8:113903268-113935005 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033936
 protein coding gene Chr8:124611666-124650920 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034645
 protein coding gene Chr8:112272810-112308824 (-)
PWK/PhJ MGP_PWKPhJ_G0032847
 protein coding gene Chr8:107982863-108015352 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032686
 protein coding gene Chr8:110960870-110990037 (-)
WSB/EiJ MGP_WSBEiJ_G0033260
 protein coding gene Chr8:112959816-112994954 (-)



Homology
more
  • Human Ortholog
    DDX19B, DEAD-box helicase 19B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX19B, DEAD-box helicase 19B
  • Synonyms
    DBP5, DDX19, RNAh
  • Links
    NCBI Gene ID: 11269
    UniProt: Q9UMR2

  • Chr Location
    16q22.1; chr16:70289663-70335305 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is embryonic lethal. Heterozygous KO leads to increased resistance to RNA virus infection.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    4
  • cDNA Data
    79
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033658 Ensembl Gene Model | MGI Sequence Detail 28564 C57BL/6J ±  kb
    transcript ENSMUST00000065784 Ensembl | MGI Sequence Detail 3104 Not Applicable  
    polypeptide ENSMUSP00000066806 Ensembl | MGI Sequence Detail 494 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
      3.6.4.13
    • InterPro Domains
      IPR011545 DEAD/DEAH box helicase domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR014014 RNA helicase, DEAD-box type, Q motif
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 80

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918149, MGI:2142782
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/16/2026
    MGI 6.24     		The Jackson Laboratory