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Prrxl1 Gene Detail
Summary
  • Symbol
    Prrxl1
  • Name
    paired related homeobox protein-like 1
  • Synonyms
    Drg11
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148204
    NCBI Gene: 107751
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:32599407-32649246 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    344 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148204
protein coding gene Chr14:32595833-32649246 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021148
protein coding gene Chr14:25853390-25906573 (+)
A/J MGP_AJ_G0021096
protein coding gene Chr14:24867457-24918901 (+)
AKR/J MGP_AKRJ_G0021073
protein coding gene Chr14:26024920-26074320 (+)
BALB/cJ MGP_BALBcJ_G0021100
protein coding gene Chr14:25050287-25100639 (+)
C3H/HeJ MGP_C3HHeJ_G0020883
protein coding gene Chr14:25897252-25948437 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021532
protein coding gene Chr14:26878721-26931573 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019094
protein coding gene Chr14:24933676-24985009 (+)
CAST/EiJ MGP_CASTEiJ_G0020408
protein coding gene Chr14:25702548-25760410 (+)
CBA/J MGP_CBAJ_G0020850
protein coding gene Chr14:27876450-27938216 (+)
DBA/2J MGP_DBA2J_G0020972
protein coding gene Chr14:24894859-24944462 (+)
FVB/NJ MGP_FVBNJ_G0020956
protein coding gene Chr14:24860193-24911106 (+)
LP/J MGP_LPJ_G0021041
protein coding gene Chr14:26169866-26225871 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020982
protein coding gene Chr14:27089980-27141765 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021565
protein coding gene Chr14:25811864-25866255 (+)
PWK/PhJ MGP_PWKPhJ_G0020156
protein coding gene Chr14:24384636-24434691 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019980
protein coding gene Chr14:25426898-25486489 (+)
WSB/EiJ MGP_WSBEiJ_G0020463
protein coding gene Chr14:25874835-25926453 (+)



Homology
more
  • Human Ortholog
    DRGX, dorsal root ganglia homeobox
  • Human Ortholog
    DRGX, dorsal root ganglia homeobox
    Orthology source: HGNC
  • Synonyms
    DRG11, PRRXL1
  • Links
    NCBI Gene ID: 644168
    neXtProt AC: NX_A6NNA5
    UniProt: A6NNA5

  • Chr Location
    10q11.23; chr10:49364085-49396016 (-)  GRCh38.p7

  • HCOP
    human homology predictions: DRGX
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice had delayed projection of sensory afferent neurons in the dorsal, but not the ventral, spinal cord during embryonic development. This delayed development resulted in abnormal responses to noxious stimuli in adults, but normal locomotion and sensory motor function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041730 Ensembl Gene Model | MGI Sequence Detail 49840 C57BL/6J ±  kb
    transcript ENSMUST00000186452 Ensembl | MGI Sequence Detail 2371 Not Applicable  
    polypeptide ENSMUSP00000139756 Ensembl | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 7
      Primer pair 6
      Other 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 33
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:70560 Chen Z, et al., The paired homeodomain protein drg11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001 Jul 19;31(1):59-73
    • Latest
      J:269168 Hernandez-Miranda LR, et al., Mutation in LBX1/Lbx1 precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13021-13026

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory