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Ces1d
Gene Detail
Symbol

Name
ID
Ces1d
carboxylesterase 1D
MGI:2148202
Synonyms
Ces3, TGH
Feature Type
protein coding gene
Genetic Map
Chromosome 8
45.05 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:93166068-93197838 bp, - strand
From VEGA annotation of GRCm38

  31771 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35606  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 3 cattle; 1 dog; 2 chicken; 7 western clawed frog; 3 zebrafish

HCOP human homology predictions: CES1
Protein SuperFamily: esterase, acetylcholinesterase type
Gene Tree: Ces1d

Human
homologs
CES1, carboxylesterase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1066
neXtProt AC: NX_P23141

Human Synonyms: ACAT, CE-1, CEH, CES2, hCE-1, HMSE, HMSE1, PCE-1, REH, SES1, TGH

Human Chr (Location): 16q22.2; chr16:55802851-55833186 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CES1

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit decreased blood lipids, improved glucose tolerance, and increased energy expenditure.
 
Interactions
Ces1d interacts with 42 markers (Mir1a-1, Mir1a-2, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process acyl-CoA metabolic process, acylglycerol catabolic process, ...
Component cytoplasm, cytosol, ...
Function carboxylic ester hydrolase activity, fatty-acyl-ethyl-ester synthase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (192)    Tissues (110)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 190
RT-PCR 2
cDNA source data(106)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: GEISHA CES1 ; Xenbase ces3    NEW 
Molecular
reagents
All nucleic(107) cDNA(106) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000024539 (Evidence)
Ensembl Gene Model ENSMUSG00000056973 (Evidence)
Entrez Gene 104158 (Evidence)
UniGene 292803
DFCI TC1576437
DoTS DT.55281470, DT.496102, DT.101409777, DT.97357211
NIA Mouse Gene Index U030101
EC 3.1.1.67, 3.1.1.1
Consensus CDS Project CCDS22528.1
International Mouse Phenotyping Consortium Status Ces1d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024539 VEGA Gene Model | MGI Sequence Detail 31771 C57BL/6J ±  kb
transcript OTTMUST00000060241 VEGA | MGI Sequence Detail 2004 Not Applicable 
polypeptide OTTMUSP00000029377 VEGA | MGI Sequence Detail 565 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019826 Carboxylesterase type B, active site
InterPro IPR019819 Carboxylesterase type B, conserved site
Protein Ontology PR:000033259 carboxylesterase 1D
References
(Earliest) J:113779 Mori M, et al., cDNA cloning, characterization and stable expression of novel human brain carboxylesterase. FEBS Lett. 1999 Sep 10;458(1):17-22
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory