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Slc38a5 Gene Detail
Summary
  • Symbol
    Slc38a5
  • Name
    solute carrier family 38, member 5
  • Synonyms
    C81234, JM24, SN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148066
    NCBI Gene: 209837
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:8271381-8280179 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148066
protein coding gene ChrX:8271133-8280179 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035546
protein coding gene ChrX:2928560-2938725 (+)
A/J MGP_AJ_G0035523
protein coding gene ChrX:2909487-2918255 (+)
AKR/J MGP_AKRJ_G0035456
protein coding gene ChrX:3025508-3034537 (+)
BALB/cJ MGP_BALBcJ_G0035520
protein coding gene ChrX:2894108-2903150 (+)
C3H/HeJ MGP_C3HHeJ_G0035228
protein coding gene ChrX:2987050-2996149 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036044
protein coding gene ChrX:3036831-3045753 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032919
protein coding gene ChrX:2420735-2429662 (+)
CAST/EiJ MGP_CASTEiJ_G0034529
protein coding gene ChrX:2866768-2877741 (+)
CBA/J MGP_CBAJ_G0035198
protein coding gene ChrX:3184159-3196518 (+)
DBA/2J MGP_DBA2J_G0035355
protein coding gene ChrX:2879484-2888396 (+)
FVB/NJ MGP_FVBNJ_G0035302
protein coding gene ChrX:2856515-2865444 (+)
LP/J MGP_LPJ_G0035432
protein coding gene ChrX:2950579-2959574 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035342
protein coding gene ChrX:3125955-3136223 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036062
protein coding gene ChrX:2908727-2917969 (+)
PWK/PhJ MGP_PWKPhJ_G0034229
protein coding gene ChrX:2823476-2832575 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034068
protein coding gene ChrX:2888979-2900057 (+)
WSB/EiJ MGP_WSBEiJ_G0034652
protein coding gene ChrX:2912999-2921882 (+)



Homology
more
  • Human Ortholog
    SLC38A5, solute carrier family 38 member 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC38A5, solute carrier family 38 member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JM24, pp7194, SN2, SNAT5
  • Links
    NCBI Gene ID: 92745
    neXtProt AC: NX_Q8WUX1
    UniProt: Q8WUX1

  • Chr Location
    Xp11.23; chrX:48458537-48470256 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
The gene product plays a role in mediating amino-acid-stimulated pancreatic alpha cell proliferation. Under glucagon receptor (Gcgr) inhibition conditions, homozygous KO reduces alpha cell hyperplasia and causes hypoglycemia and increased plasma glucagon and amino acid levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 209837 NCBI Gene Model | MGI Sequence Detail 8799 C57BL/6J ±  kb
transcript NM_172479 RefSeq | MGI Sequence Detail 1878 C57BL/6  
polypeptide Q3U1J0 UniProt | EBI | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 22
    Primer pair 4

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:251829 Kim J, et al., Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic alpha Cell Hyperplasia in Mice. Cell Metab. 2017 Jun 6;25(6):1348-1361.e8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory