About   Help   FAQ
Nexmif Gene Detail
Summary
  • Symbol
    Nexmif
  • Name
    neurite extension and migration factor
  • Synonyms
    C77370, Xpn
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148050
    NCBI Gene: 245555
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:104077434-104201185 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 46.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148050
protein coding gene ChrX:104076761-104201783 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035989
protein coding gene ChrX:100773581-100905508 (-)
A/J MGP_AJ_G0035970
protein coding gene ChrX:100667478-100782822 (-)
AKR/J MGP_AKRJ_G0035888
protein coding gene ChrX:103757156-103884516 (-)
BALB/cJ MGP_BALBcJ_G0035960
protein coding gene ChrX:99460151-99578537 (-)
C3H/HeJ MGP_C3HHeJ_G0035666
protein coding gene ChrX:101231520-101348154 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036486
protein coding gene ChrX:103725373-103846336 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033314
protein coding gene ChrX:98272969-98382827 (-)
CAST/EiJ MGP_CASTEiJ_G0034952
protein coding gene ChrX:85480740-85604467 (-)
CBA/J MGP_CBAJ_G0035641
protein coding gene ChrX:106939041-107062225 (-)
DBA/2J MGP_DBA2J_G0035795
protein coding gene ChrX:99914701-100032825 (-)
FVB/NJ MGP_FVBNJ_G0035736
protein coding gene ChrX:99213120-99342558 (-)
LP/J MGP_LPJ_G0035888
protein coding gene ChrX:101765565-101885825 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035768
protein coding gene ChrX:111595744-111737077 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036512
protein coding gene ChrX:100453010-100571929 (-)
PWK/PhJ MGP_PWKPhJ_G0034650
protein coding gene ChrX:83056310-83174415 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034478
protein coding gene ChrX:86190115-86312387 (-)
WSB/EiJ MGP_WSBEiJ_G0035092
protein coding gene ChrX:99178811-99295763 (-)



Homology
more
  • Human Ortholog
    NEXMIF, neurite extension and migration factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEXMIF, neurite extension and migration factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA2022, KIDLIA, MRX98, XPN
  • Links
    NCBI Gene ID: 340533
    neXtProt AC: NX_Q5QGS0
    UniProt: Q5QGS0

  • Chr Location
    Xq13.3; chrX:74732856-74925452 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 19589
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NEXMIF
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Nexmif mouse models; 1 with human NEXMIF associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele show seizures, autism-like behaviors including reduced sociability, repetitive self-grooming, hyperactivity, decreased vocalization and deficits in spatial and fear memory, as well as a reduction in dendritic spine density and synaptic transmission.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046449 Ensembl Gene Model | MGI Sequence Detail 123752 C57BL/6J ±  kb
    transcript ENSMUST00000087879 Ensembl | MGI Sequence Detail 10891 Not Applicable  
    polypeptide ENSMUSP00000085187 Ensembl | MGI Sequence Detail 1515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR032757 Domain of unknown function DUF4683
      IPR042794 Neurite extension and migration factor
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2148051
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:283395 Gilbert J, et al., NEXMIF/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function. J Neurosci. 2020 Jan 2;40(1):237-254

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    02/16/2021
    MGI 6.16
    The Jackson Laboratory