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Pcyt1b
Gene Detail
 Symbol
Name
ID
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
MGI:2147987
Synonyms CTTbeta
Feature Type protein coding gene
Genetic Map
Chromosome X
41.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:93654863-93749951 bp, + strand
From VEGA annotation of GRCm38

  95089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: choline-phosphate cytidylyltransferase
Gene Tree: Pcyt1b

Human
homologs
Human Homolog PCYT1B, phosphate cytidylyltransferase 1, choline, beta
NCBI Gene ID 9468
neXtProt AC  NX_Q9Y5K3
Human Synonyms  CCTB, CTB
Human Chr (Location)  Xp22.11; chrX:24558087-24672862 (-)  GRCh38
Alleles
and
phenotypes
All alleles(117) : Gene trapped(116) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice reduced fertility, abnormal ovaries with absent corpora lutea and follicles, benign ovarian tumors, seminiferous tubule degeneration, and reduced spermatogenesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process biosynthetic process, lipid metabolic process, ...
Component endoplasmic reticulum
Function catalytic activity, choline-phosphate cytidylyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (366)    Tissues (176)    Images (49)
Theiler Stages: 10, 13, 15, 18, 19, 20, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 230
Northern blot 12
Western blot 2
RT-PCR 122
cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(75) cDNA(70) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017967 (Evidence)
Ensembl Gene ModelENSMUSG00000035246 (Evidence)
Entrez Gene236899 (Evidence)
UniGene166467
DFCITC1581066, TC1591359, TC1626499
DoTSDT.55281343, DT.97339986, DT.97358812
NIA Mouse Gene IndexU020011
EC2.7.7.15
Consensus CDS ProjectCCDS30274.1, CCDS41061.1
International Mouse Knockout Project StatusPcyt1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017967 VEGA Gene Model | MGI Sequence Detail 95089 C57BL/6J ±  kb
transcript OTTMUST00000043399 VEGA | MGI Sequence Detail 4888 Not Applicable 
polypeptide OTTMUSP00000019496 VEGA | MGI Sequence Detail 369 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(269 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004821 Cytidyltransferase-like domain
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Protein Ontology PR:000012447 choline-phosphate cytidylyltransferase B
References (Earliest) J:84309 Karim M, et al., Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform. Biochim Biophys Acta. 2003 Jul 4;1633(1):1-12
(Latest) J:177611 Strakova J, et al., Involvement of CTP:phosphocholine cytidylyltransferase-beta2 in axonal phosphatidylcholine synthesis and branching of neurons. Biochim Biophys Acta. 2011 Oct;1811(10):617-25
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory