Igsf1
Gene Detail

Symbol Name ID

Igsf1 immunoglobulin superfamily, member 1 MGI:2147913

Feature Type

protein coding gene

Genetic Map

Chromosome X

26.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:49782536-49797749 bp, - strand From VEGA annotation of GRCm38   15214 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Igsf1

Human homologs

Human Homolog		IGSF1, immunoglobulin superfamily, member 1
NCBI Gene ID		3547
neXtProt AC		NX_Q8N6C5
Human Synonyms		CHTE, IGCD1, IGDC1, INHBP, p120, PGSF2
Human Chr (Location)		Xq25; chrX:130407480-130423403 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IGSF1

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous or hemizygous for disruptions of this gene show no obvious phenotypic change.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	regulation of transcription, DNA-dependent, signal transduction
Component	extracellular region, integral to membrane, ...
Function	coreceptor activity, inhibin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (75)    Tissues (40)    Images (28)
Theiler Stages: 12, 19, 20, 22, 23, 24, 28

Assay Type	Results
RNA in situ	74
RT-PCR	1

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000017798 (Evidence)
Ensembl Gene Model	ENSMUSG00000031111 (Evidence)
Entrez Gene	209268 (Evidence)
UniGene	110505
DFCI	TC1578393, TC1588473
DoTS	DT.101734861, DT.111035998, DT.527529, DT.87027880, DT.94204566
Consensus CDS Project	CCDS40964.1, CCDS40965.1, CCDS40966.1, CCDS40967.1
International Mouse Knockout Project Status	Igsf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017798	VEGA Gene Model | MGI Sequence Detail	15214	C57BL/6J
transcript	OTTMUST00000043083	VEGA | MGI Sequence Detail	4421	Not Applicable
polypeptide	OTTMUSP00000019372	VEGA | MGI Sequence Detail	1317	Not Applicable

All sequences(57) RefSeq(8) UniProt(2)

Polymorphisms

SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000008968	immunoglobulin superfamily member 1

References

(Earliest) J:84383 Bernard DJ, et al., Normal reproductive function in InhBP/p120-deficient mice. Mol Cell Biol. 2003 Jul;23(14):4882-91
(Latest) J:190867 Sun Y, et al., Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nat Genet. 2012 Dec;44(12):1375-81
All references(31)