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Atg4a Gene Detail
Summary
  • Symbol
    Atg4a
  • Name
    autophagy related 4A, cysteine peptidase
  • Synonyms
    Apg4a, Autl2, autophagin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147903
    NCBI Gene: 666468
  • Gene Overview
    MyGene.info: ATG4A
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:140956907-141164270 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 61.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147903
protein coding gene ChrX:140953893-141164270 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036140
protein coding gene ChrX:138534562-138632501 (+)
A/J MGP_AJ_G0036118
protein coding gene ChrX:137899462-137997561 (+)
AKR/J MGP_AKRJ_G0036043
protein coding gene ChrX:142328739-142437533 (+)
BALB/cJ MGP_BALBcJ_G0036108
protein coding gene ChrX:136204215-136297908 (+)
C3H/HeJ MGP_C3HHeJ_G0035817
protein coding gene ChrX:138532726-138744207 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036633
protein coding gene ChrX:142562148-142656449 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033457
protein coding gene ChrX:129591958-129679316 (+)
CAST/EiJ MGP_CASTEiJ_G0035108
protein coding gene ChrX:119360809-119461593 (+)
CBA/J MGP_CBAJ_G0035794
protein coding gene ChrX:146972429-147069782 (+)
DBA/2J MGP_DBA2J_G0035951
protein coding gene ChrX:137030088-137125752 (+)
FVB/NJ MGP_FVBNJ_G0035885
protein coding gene ChrX:136260503-136353771 (+)
LP/J MGP_LPJ_G0036042
protein coding gene ChrX:139472856-139568022 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0036669
protein coding gene ChrX:137839849-137935524 (+)
PWK/PhJ MGP_PWKPhJ_G0034801
protein coding gene ChrX:116244550-116337630 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034627
protein coding gene ChrX:119900660-119972021 (+)
WSB/EiJ MGP_WSBEiJ_G0035243
protein coding gene ChrX:136155461-136194818 (+)



Homology
more
  • Human Ortholog
    ATG4A, autophagy related 4A cysteine peptidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATG4A, autophagy related 4A cysteine peptidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APG4A, AUTL2
  • Links
    NCBI Gene ID: 115201
    neXtProt AC: NX_Q8WYN0
    UniProt: Q8WYN0

  • Chr Location
    Xq22.3; chrX:108088900-108154671 (+)  GRCh38.p7

Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079418 Ensembl Gene Model | MGI Sequence Detail 207364 C57BL/6J ±  kb
transcript ENSMUST00000112971 Ensembl | MGI Sequence Detail 2202 Not Applicable  
polypeptide ENSMUSP00000108595 Ensembl | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147980
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 5
  • Earliest
    J:81439 Marino G, et al., Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem. 2003 Feb 7;278(6):3671-8
  • Latest
    J:231471 Zhang L, et al., Unraveling the roles of Atg4 proteases from autophagy modulation to targeted cancer therapy. Cancer Lett. 2016 Apr 1;373(1):19-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory