About   Help   FAQ
Fermt3
Gene Detail
 Symbol
Name
ID
Fermt3
fermitin family homolog 3 (Drosophila)
MGI:2147790
Synonyms C79673, Kindlin-3, MGC:36836, MGC:38286
Feature Type protein coding gene
Genetic Map
Chromosome 19
5.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:6998958-7019469 bp, - strand
From NCBI annotation of GRCm38

  20512 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12877  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Fermt3

Human
homologs
Human Homolog FERMT3, fermitin family member 3
NCBI Gene ID 83706
neXtProt AC  NX_Q86UX7
Human Synonyms  KIND3, MIG-2, MIG2B, UNC112C, URP2, URP2SF
Human Chr (Location)  11q13.1; chr11:64206680-64223891 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FERMT3
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Disruption of this marker results in lethality in the first week after birth, abnormal erythropoiesis and platelet function, and severe hemorrhage.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, integrin activation, ...
Component cell junction, cell projection, ...
Function integrin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (67)    Tissues (35)    Images (6)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 10
Northern blot 14
Western blot 15
RT-PCR 27
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024965 (Evidence)
Entrez Gene108101 (Evidence)
NIA Mouse Gene IndexU038671
Consensus CDS ProjectCCDS29518.1
International Mouse Knockout Project StatusFermt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 108101 NCBI Gene Model | MGI Sequence Detail 20512 C57BL/6J ±  kb
transcript NM_153795 RefSeq | MGI Sequence Detail 2587 C57BL/6 
polypeptide Q8K1B8 UniProt | EBI | MGI Sequence Detail 665 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR019748 FERM central domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000029845 fermitin family homolog 3
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:203825 Petzold T, et al., beta1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse. Blood. 2013 Oct 10;122(15):2723-31
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory