Fermt3
Gene Detail

Symbol Name ID

Fermt3 fermitin family homolog 3 (Drosophila) MGI:2147790

Synonyms

C79673, Kindlin-3, MGC:36836, MGC:38286

Feature Type

protein coding gene

Genetic Map

Chromosome 19

5.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:6998958-7019469 bp, - strand From NCBI annotation of GRCm38   20512 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12877  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Fermt3

Human homologs

Human Homolog		FERMT3, fermitin family member 3
NCBI Gene ID		83706
neXtProt AC		NX_Q86UX7
Human Synonyms		KIND3, MIG-2, MIG2B, UNC112C, URP2, URP2SF
Human Chr (Location)		11q13.1; chr11:63974152-63991363 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FERMT3

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Disruption of this marker results in lethality in the first week after birth, abnormal erythropoiesis and platelet function, and severe hemorrhage.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell adhesion, integrin activation, ...
Component	cell junction, cell projection, ...
Function	integrin binding, phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (67)    Tissues (35)    Images (6)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	10
Northern blot	14
Western blot	15
RT-PCR	27

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000024965 (Evidence)
Entrez Gene	108101 (Evidence)
NIA Mouse Gene Index	U038671
Consensus CDS Project	CCDS29518.1
International Mouse Knockout Project Status	Fermt3

Sequences

Length	Strain/Species
genomic	108101	NCBI Gene Model | MGI Sequence Detail	20512	C57BL/6J
transcript	NM_153795	RefSeq | MGI Sequence Detail	2587	C57BL/6
polypeptide	Q8K1B8	UniProt | EBI | MGI Sequence Detail	665	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(72 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019749	Band 4.1 domain
InterPro	IPR014352	FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro	IPR019748	FERM central domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000029845	fermitin family homolog 3

Graphical View of Protein Domain Structure

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:185175 Lefort CT, et al., Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood. 2012 May 3;119(18):4275-82
All references(35)