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Fermt3
Gene Detail
Symbol

Name
ID
Fermt3
fermitin family homolog 3 (Drosophila)
MGI:2147790
Synonyms
C79673, Kindlin-3, MGC:36836, MGC:38286
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:6998958-7019469 bp, - strand
From NCBI annotation of GRCm38

  20512 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12877  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

HCOP human homology predictions: FERMT3
Gene Tree: Fermt3

Human
homologs
FERMT3, fermitin family member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 83706
neXtProt AC: NX_Q86UX7

Human Synonyms: KIND3, MIG-2, MIG2B, UNC112C, URP2, URP2SF

Human Chr (Location): 11q13.1; chr11:64206655-64223891 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FERMT3

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Disruption of this marker results in lethality in the first week after birth, abnormal erythropoiesis and platelet function, and severe hemorrhage.
 
Interactions
Fermt3 interacts with 63 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell adhesion, integrin activation, ...
Component cell junction, cell projection, ...
Function integrin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (67)    Tissues (35)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 10
Northern blot 14
Western blot 15
RT-PCR 27
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fermt3    NEW 
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000024965 (Evidence)
Entrez Gene 108101 (Evidence)
NIA Mouse Gene Index U038671
Consensus CDS Project CCDS29518.1
International Mouse Phenotyping Consortium Status Fermt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 108101 NCBI Gene Model | MGI Sequence Detail 20512 C57BL/6J ±  kb
transcript NM_153795 RefSeq | MGI Sequence Detail 2587 C57BL/6 
polypeptide Q8K1B8 UniProt | EBI | MGI Sequence Detail 665 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR019748 FERM central domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Protein Ontology PR:000029845 fermitin family homolog 3
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:210761 Kasirer-Friede A, et al., ADAP interactions with talin and kindlin promote platelet integrin alphaIIbbeta3 activation and stable fibrinogen binding. Blood. 2014 May 15;123(20):3156-65
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory